Quarterly Revenue Growth (GAAP)
Total revenue for Q4 was $43.9 million, up 25% year-over-year and up 7% sequentially, driven in part by acquisitions and release of pent-up demand from academic customers.
Diagnostics Partnerships and Revenue Growth
Diagnostics partnerships grew to 25 partnerships that generated $9.6 million in revenue in 2025 versus $6.0 million in the prior year (approximately +60% year-over-year), expanding the Diagnostics revenue base.
LucentAD Regulatory and Reimbursement Milestones
LucentAD achieved a CMS reimbursement crosswalk establishing a reference price of $897 and a 510(k) submission to the FDA was filed in January 2026; management expects FDA review in ~6–9 months, supporting future commercial rollout.
Product Innovation and Assay Launches
Launched 13 new assays in 2025 (including two new Simoa Tau assays, pTau-205 and pTau-212) with strong initial interest; management expects a regular cadence of assay launches quarterly through 2026.
Gross Margin and Non-GAAP Profitability Improvements
Q4 GAAP gross margin was 45.7% (gross profit $20.0M); non-GAAP gross margin was 50% (non-GAAP gross profit $21.9M). Non-GAAP operating expenses decreased to $37.0M and adjusted EBITDA improved to a loss of $7.9M (a sequential improvement of $4.0M vs Q3).
Synergy Realization and Cost Discipline
Implemented $74 million of an $85 million cost synergy target and on track to achieve the full target by end of Q1, contributing to sequential operating expense reductions and improved cash usage.
Strong Cash Position and Improved Cash Usage
Ended Q4 with $122 million in cash, equivalents and marketable securities; adjusted cash usage improved to $3.0M in the quarter versus $16.1M in Q3, and the company expects to reach cash-flow breakeven in H2 2026 and end the year with approximately $100M cash and no debt.
Instrument Placements and Consumables Momentum
Placed 21 Simoa and 17 Spatial instruments in the quarter (versus 18 Simoa in Q4 2024); consumables revenue was $23.0M and increased $3.8M sequentially (Simoa $15.4M, Spatial $7.6M), supporting recurring revenue streams.