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PainReform (PRFX)
NASDAQ:PRFX
US Market

PainReform (PRFX) AI Stock Analysis

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PRFX

PainReform

(NASDAQ:PRFX)

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Neutral 44 (OpenAI - 5.2)
Rating:44Neutral
Price Target:
$0.76
▼(-5.00% Downside)
The score is weighed down primarily by weak financial performance (minimal revenue, widening losses, and rising cash burn alongside shrinking equity). Technicals also remain bearish with the stock trading below key moving averages, while valuation cannot be meaningfully assessed due to missing P/E and dividend yield data.
Positive Factors
Low Financial Leverage
Very low reported debt materially reduces near-term default and interest-rate risk, giving management optionality to prioritize R&D or strategic investments without large fixed financing costs. This structural low-leverage position improves resilience during multi-quarter development cycles.
Strategic Diversification
The shift from a single-asset pain-treatment focus toward a combined healthcare and renewable-energy platform broadens addressable markets and reduces concentration risk. Diversification across LayerBio ocular tech and DeepSolar analytics creates multiple potential revenue streams and strategic optionality over the medium term.
Clinical Safety Progress
Positive Phase I safety data materially de-risks the ocular delivery program and supports advancement to later-stage trials and IND-enabling work. Safety validation increases the probability of clinical progression and eventual commercialization in a large cataract-care market if efficacy is subsequently demonstrated.
Negative Factors
Persistent Cash Burn
Sustained, worsening negative operating and free cash flow implies ongoing reliance on external financing to fund operations and trials. That structural cash burn pressures strategic flexibility, elevates dilution risk, and constrains the company’s ability to self-fund multiple development programs over coming quarters.
Minimal Revenue and Widening Losses
Near-zero revenue and growing net losses indicate the business remains pre-commercial with limited internal cash generation. Without durable revenue, the firm cannot offset R&D and SG&A spending, making long-term sustainability dependent on successful product launches or continued external capital.
Eroded Shareholders' Equity
A sharply reduced equity base weakens the balance sheet buffer against setbacks and increases the probability management must raise capital. Repeated equity issuance would dilute existing holders and could limit the company's ability to absorb trial failures or fund parallel development programs over the medium term.

PainReform (PRFX) vs. SPDR S&P 500 ETF (SPY)

PainReform Business Overview & Revenue Model

Company DescriptionPRF Technologies Ltd., a clinical stage specialty pharmaceutical company, engages in the development of therapeutics that provides an extended period of post-surgical pain relief in Israel. It engages in developing PRF-110, a viscous clear oil-based solution that is instilled directly into the surgical wound to provide localized and extended post-operative analgesia. The company is currently conducting two Phase 3 clinical trials of PRF-110 for the treatment of patients undergoing bunionectomy surgery and hernia repair. PainReform Ltd. was incorporated in 2007 and is based in Tel Aviv, Israel.
How the Company Makes MoneyPainReform generates revenue primarily through the development and potential commercialization of its proprietary drug formulations. The company's revenue model is centered around advancing its flagship product, PRF-110, through clinical trials and securing regulatory approval for market entry. Once approved, PainReform aims to license its formulations to larger pharmaceutical companies or engage in direct sales, thereby earning licensing fees, milestone payments, and royalties. The company may also explore partnerships or collaborations to enhance its research capabilities and expand its market reach.

PainReform Financial Statement Overview

Summary
Financial performance is very weak: revenue is effectively negligible, losses widened in 2024, and operating/free cash flow deteriorated with higher cash burn. Low debt reduces leverage risk, but equity has eroded sharply, increasing dilution/financing risk.
Income Statement
12
Very Negative
The income statement remains very weak: revenue is effectively zero in most years (only $86K in 2022), while losses have widened meaningfully, with net income falling from -$9.3M (2023) to -$14.6M (2024). Profitability is structurally negative (large negative EBIT/EBITDA each year), which signals a business still in heavy development mode with limited commercial traction. A modest positive is that gross profit in 2022 was positive, but it has not translated into sustainable revenue or improving earnings power.
Balance Sheet
48
Neutral
The balance sheet shows low financial leverage (debt is minimal at ~$45K in 2024, and debt-to-equity is very low), which reduces default risk. However, the company’s capital base has deteriorated sharply: stockholders’ equity declined from ~$11.0M (2022) to ~$1.8M (2024), alongside continued losses, and return on equity is deeply negative in 2024. Overall, low debt is a clear strength, but the shrinking equity cushion is a key risk.
Cash Flow
18
Very Negative
Cash flow is pressured by persistent cash burn. Operating cash flow was negative every year and worsened to about -$12.6M in 2024 from about -$6.7M in 2023, with free cash flow also deeply negative (roughly -$12.6M in 2024). While free cash flow has generally tracked net losses (free cash flow to net income ~1.0), the direction of cash burn is unfavorable and implies ongoing reliance on external funding unless operating performance improves.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.0086.00K0.000.00
Gross Profit0.00-16.00K-15.00K71.00K0.00
EBITDA-3.94M-14.55M-9.57M-8.76M-7.20M-1.67M
Net Income-4.09M-14.59M-9.34M-8.79M-7.25M-4.05M
Balance Sheet
Total Assets11.16M4.53M9.93M12.33M19.07M17.80M
Cash, Cash Equivalents and Short-Term Investments3.48M4.26M8.03M4.10M16.54M15.68M
Total Debt56.00K45.00K86.00K0.000.000.00
Total Liabilities2.72M2.70M2.69M1.31M991.00K1.18M
Stockholders Equity8.44M1.82M7.24M11.02M18.08M16.62M
Cash Flow
Free Cash Flow-5.96M-12.63M-6.69M-6.46M-6.60M-2.57M
Operating Cash Flow-5.96M-12.62M-6.68M-6.46M-6.55M-2.56M
Investing Cash Flow-51.00K-13.00K5.99M-6.01M-50.00K-10.00K
Financing Cash Flow6.70M8.86M4.62M0.007.48M17.31M

PainReform Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.80
Price Trends
50DMA
0.88
Negative
100DMA
1.10
Negative
200DMA
1.42
Negative
Market Momentum
MACD
>-0.01
Negative
RSI
43.73
Neutral
STOCH
6.90
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PRFX, the sentiment is Negative. The current price of 0.8 is below the 20-day moving average (MA) of 0.81, below the 50-day MA of 0.88, and below the 200-day MA of 1.42, indicating a bearish trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 43.73 is Neutral, neither overbought nor oversold. The STOCH value of 6.90 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PRFX.

PainReform Risk Analysis

PainReform disclosed 46 risk factors in its most recent earnings report. PainReform reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

PainReform Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$6.67M
44
Neutral
$2.99M
42
Neutral
$6.43M-1.24-42.47%-26.92%69.90%
40
Underperform
$18.95M-0.71-63.82%
32
Underperform
$3.56M-0.10-9999.00%79.31%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PRFX
PainReform
0.76
-2.64
-77.53%
CPHI
China Pharma Holdings
1.28
-0.97
-43.11%
RDHL
RedHill Biopharma
1.31
-4.82
-78.63%
COSM
Cosmos Holdings
0.51
-0.19
-27.71%
SHPH
Shuttle Pharmaceuticals Holdings, Inc.
2.22
-17.36
-88.66%

PainReform Corporate Events

PRF Technologies Files First Patent for AI-Driven Solar Micro-Climate Forecasting
Jan 20, 2026

On January 20, 2026, PRF Technologies announced it had filed its first patent application for proprietary micro-climate modeling methods designed to significantly enhance the accuracy of power production forecasts at individual solar plants. The filing, which follows the company’s acceptance into the NVIDIA Connect Program, underpins its DeepSolar Predict forecasting platform and targets a key weakness in conventional, region-based solar forecasts by continuously adapting to localized weather conditions at each installation. By improving short-term and intraday forecast precision, PRF aims to help utility-scale solar operators and energy traders better manage revenue, reduce penalties tied to forecast errors, and optimize participation in volatile electricity markets. The move strengthens PRF’s growing portfolio of energy-focused intellectual property and supports its broader strategy to expand in data-driven renewable energy optimization, potentially reinforcing its position at the intersection of AI, clean energy, and financial performance for solar assets.

The most recent analyst rating on (PRFX) stock is a Hold with a $1.00 price target. To see the full list of analyst forecasts on PainReform stock, see the PRFX Stock Forecast page.

PainReform Rebrands as PRF Technologies to Reflect Expansion into Healthcare and AI-Driven Energy
Jan 15, 2026

On January 15, 2026, PainReform Ltd. announced it had changed its corporate name to PRF Technologies Ltd., following shareholder approval at the company’s January 6, 2026 annual general meeting, in a move designed to signal its evolution beyond a single-asset pain-treatment developer into a diversified healthcare and clean-energy technology platform. The rebranding highlights the company’s broadened portfolio, which now includes LayerBio’s OcuRing-K sustained-release ocular therapy for post-cataract surgery care and the DeepSolar AI-based solar analytics and forecasting business, positioning PRF to pursue multiple growth paths and reduce reliance on any single product as it targets large, high-growth markets in both specialty pharmaceuticals and renewable energy.

The most recent analyst rating on (PRFX) stock is a Sell with a $0.78 price target. To see the full list of analyst forecasts on PainReform stock, see the PRFX Stock Forecast page.

PainReform Reports Positive Phase I Safety Data for OcuRing-K Ocular Drug Platform
Jan 12, 2026

On January 12, 2026, PainReform and its majority-owned subsidiary LayerBio reported that their OcuRing™-K drop-less, sustained-release intraocular drug delivery platform for cataract surgery demonstrated a favorable safety profile in a series of preclinical rabbit studies and a Phase I human clinical trial. The studies found no treatment-related adverse events, no serious adverse events, proper positioning of the investigational product and intraocular lenses in all treated eyes, and no meaningful safety differences versus controls, reinforcing the platform’s tolerability and biocompatibility and supporting advancement toward investigational new drug-enabling activities and later-stage clinical development in the United States, a step that could strengthen PainReform’s positioning in ophthalmic drug delivery and post-surgical care.

The most recent analyst rating on (PRFX) stock is a Hold with a $0.70 price target. To see the full list of analyst forecasts on PainReform stock, see the PRFX Stock Forecast page.

PainReform Files Pro Forma Financials Following Majority Acquisition of LayerBio
Jan 7, 2026

On January 7, 2026, PainReform Ltd. filed a Form 6-K in the United States providing updated financial disclosure related to its acquisition of LayerBio Inc., a transaction first announced in July 2025 and completed on August 13, 2025, in which PainReform acquired 7,331,378 preferred shares representing a 51% controlling stake. The filing supplies investors with unaudited pro forma condensed combined financial information as if the deal had occurred on January 1, 2024 and June 30, 2025, along with LayerBio’s audited financial statements for 2023 and 2024 and unaudited financials for the six months ended June 30, 2025, clarifying that the acquisition qualifies as a business combination but is less than 50% significant under SEC tests and that the pro forma figures are illustrative only, without assumed synergies or forward projections, to better inform stakeholders about the combined company’s historical financial profile.

The most recent analyst rating on (PRFX) stock is a Hold with a $0.70 price target. To see the full list of analyst forecasts on PainReform stock, see the PRFX Stock Forecast page.

PainReform Shareholders Approve All Proposals at Adjourned 2026 Annual Meeting
Jan 6, 2026

On January 6, 2026, PainReform Ltd. held its Adjourned Annual General Meeting of Shareholders, at which investors approved all six proposals presented, each receiving the required majority vote. The approvals, following an earlier notice and proxy process initiated in November 2025, clear the way for the company to implement its planned corporate and governance actions as set out to shareholders, reinforcing management’s mandate and shaping the company’s operational and strategic direction for the coming year.

The most recent analyst rating on (PRFX) stock is a Hold with a $0.70 price target. To see the full list of analyst forecasts on PainReform stock, see the PRFX Stock Forecast page.

PainReform’s DeepSolar Unveils Smart TDD to Speed and Sharpen Solar Asset Due Diligence
Jan 5, 2026

On January 5, 2026, PainReform announced that its DeepSolar business unit launched Smart TDD, a next-generation solar technical due diligence service designed to deliver faster, more accurate, and more comprehensive audits of solar asset performance and risk across the $60 billion-plus global solar asset M&A market. By offering full data coverage of components and operational history, AI- and physics-based diagnostics, clearly prioritized findings, and rapid turnaround times, Smart TDD aims to replace traditional sampling- and manual inspection-based approaches, supporting investors, independent power producers, infrastructure funds, operators, lenders, and insurers at key lifecycle points such as commissioning, underperformance diagnosis, warranty expiry, and asset transactions; the launch reinforces DeepSolar’s positioning as a trusted analytics partner in a rapidly growing and increasingly complex solar secondary market, where aging assets and accelerating deal activity are driving heightened demand for high-quality, scalable technical diligence services.

The most recent analyst rating on (PRFX) stock is a Hold with a $0.70 price target. To see the full list of analyst forecasts on PainReform stock, see the PRFX Stock Forecast page.

PainReform Adjourns Annual Shareholder Meeting Due to Lack of Quorum
Dec 30, 2025

On December 30, 2025, PainReform Ltd. convened its Annual General Meeting of Shareholders in Tel Aviv but was unable to proceed with the meeting’s agenda due to a lack of quorum. As a result, the company adjourned the meeting for one week and scheduled it to be reconvened on January 6, 2026, at the same time and location at its legal counsel’s offices in Tel Aviv, signaling a minor procedural delay in its routine corporate governance process but no announced changes to operations or strategy.

The most recent analyst rating on (PRFX) stock is a Hold with a $0.70 price target. To see the full list of analyst forecasts on PainReform stock, see the PRFX Stock Forecast page.

PainReform’s LayerBio Platform Advances with Multi-Drug Capability
Dec 10, 2025

On December 10, 2025, PainReform Ltd. announced the successful R&D assessment of its LayerBio drop-less, sustained-release ocular platform, confirming its ability to incorporate multiple drug entities. This development supports the platform’s potential to improve pharmacological efficiency and simplify postoperative care for cataract patients by reducing the need for medicated eye drops. The platform’s ability to incorporate corticosteroids and NSAIDs highlights its technical feasibility for multi-drug use, offering significant advantages in patient comfort and compliance, especially for elderly cataract patients.

PainReform Initiates Phase II Development for OcuRing™-K
Dec 2, 2025

On December 2, 2025, PainReform Ltd. announced the commencement of its development plan for OcuRing™-K, a sustained-release ocular therapy designed for post-cataract surgery pain and inflammation management. This initiative marks a significant step in addressing the limitations of traditional eye-drop regimens by offering a drop-less, intraoperatively administered solution. The development plan follows PainReform’s majority investment in LayerBio and aims to advance OcuRing-K into Phase II clinical trials, potentially impacting the multi-billion-dollar global cataract surgery market by improving treatment consistency and patient compliance.

PainReform Ltd. Announces December 2025 Shareholders Meeting with Key Proposals
Nov 25, 2025

On November 25, 2025, PainReform Ltd. announced its upcoming Annual General Meeting of Shareholders scheduled for December 30, 2025, in Tel Aviv, Israel. The meeting’s agenda includes significant proposals such as the re-election of Dr. Ehud Geller to the Board, a name change to PRF Ltd., an increase in authorized share capital, a reverse stock split, and the re-appointment of Kesselman & Kesselman as the company’s auditors. These proposals, if approved, could impact the company’s operational structure and market identity, potentially influencing shareholder value and market perception.

PainReform’s DeepSolar Advances AI Reporting Engine for Solar Assets
Nov 12, 2025

On November 12, 2025, PainReform Ltd. announced that its solar energy unit, DeepSolar, has made significant progress in developing an AI-driven automated reporting engine for solar-asset analysis. This new engine is designed to streamline the process of producing performance reports, which are crucial for assessing operational and financial performance of solar plants. By automating data consolidation and analysis, the engine aims to deliver customized, insight-rich reports quickly, enhancing decision-making and maximizing asset performance. This advancement is expected to strengthen PainReform’s position in the renewable energy sector by making AI capabilities more practical and accessible, ultimately translating operational data into clear financial insights and business value.

PainReform’s DeepSolar Advances with NVIDIA Connect and Pilot Projects
Nov 5, 2025

On November 5, 2025, PainReform Ltd. announced that its solar energy unit, DeepSolar, was featured in a Watchlist Interview by The Market Link, highlighting its participation in the NVIDIA Connect program. The interview emphasized DeepSolar’s development of ‘DeepSolar Predict,’ an AI-based forecasting module designed to enhance energy production forecasts and operational decisions for solar-asset managers. This advancement addresses the growing complexity in utility-scale solar operations by improving forecast accuracy and profitability. DeepSolar is making progress toward its first pilot projects, signaling potential long-term value creation for investors and partners.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 24, 2026