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Shuttle Pharmaceuticals Holdings, Inc. (SHPH)
NASDAQ:SHPH
US Market

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) AI Stock Analysis

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SHPH

Shuttle Pharmaceuticals Holdings, Inc.

(NASDAQ:SHPH)

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Underperform 32 (OpenAI - 4o)
Rating:32Underperform
Price Target:
Shuttle Pharmaceuticals Holdings, Inc. faces significant financial challenges with no revenue and ongoing cash burn. Technical indicators show bearish trends, and valuation metrics highlight the company's unprofitability. While recent corporate activities offer potential strategic benefits, they also add financial strain and governance complexities, leading to an overall low stock score.
Positive Factors
Strategic Management Restructuring
The appointment of a new interim CEO and CSO aims to enhance business focus and capital market engagement, potentially improving strategic execution and financial management.
Successful Fundraising
The successful fundraising provides critical capital to fund Phase II clinical trials and meet Nasdaq’s equity requirements, supporting operational continuity and growth.
Clinical Trial Progress
Investing in Phase II trials for its lead product candidate indicates progress in product development, which is crucial for future revenue generation and market positioning.
Negative Factors
Financial Distress
The lack of revenue and ongoing losses highlight financial instability, posing risks to sustainability and necessitating urgent strategic and operational adjustments.
High Debt Levels
The high-interest revolving loan adds financial strain, increasing debt burden and interest obligations, which could limit operational flexibility and strategic options.
Negative Cash Flow
Persistent negative cash flow reflects unsustainable operations, requiring effective cost management and revenue generation strategies to ensure long-term viability.

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) vs. SPDR S&P 500 ETF (SPY)

Shuttle Pharmaceuticals Holdings, Inc. Business Overview & Revenue Model

Company DescriptionShuttle Pharmaceuticals Holdings, Inc., through its subsidiary, Shuttle Pharmaceuticals, Inc., focuses on the discovery, development, and commercialization of drugs for sensitizing cancers to radiation therapy. Its products in clinical stage include Ropidoxuridine, an oral halogenated pyrimidine to treat patients with brain tumors and soft tissue sarcomas; and Doranidazole, an injectable hypoxic cell radiation sensitizer for treatment of pancreatic, lung, and liver cancers. The company was founded in 2012 and is based in Rockville, Maryland.
How the Company Makes MoneyShuttle Pharmaceuticals Holdings, Inc. generates revenue primarily through the development and commercialization of its proprietary radiation sensitizer products. The company may also engage in strategic partnerships and collaborations with research institutions, pharmaceutical companies, and clinical centers to advance its product pipeline and expand its market reach. Revenue streams can include licensing agreements, milestone payments, and potential sales of its products upon regulatory approval. Additionally, the company might receive funding through grants and research contracts that support its scientific research and development efforts.

Shuttle Pharmaceuticals Holdings, Inc. Financial Statement Overview

Summary
Shuttle Pharmaceuticals Holdings, Inc. is experiencing severe financial distress with no revenue generation and significant ongoing losses. The balance sheet is weak with high liabilities compared to assets, and cash flows are negative, indicating cash burn. The company needs to address revenue growth and cost management to improve financial health.
Income Statement
The company has reported zero revenue over the years, indicating no sales activity or product commercialization. The net profit margin and other profitability metrics are negative due to ongoing losses. This reflects a challenging financial position with no revenue stream and increasing expenses.
Balance Sheet
The balance sheet shows a negative equity position in some years, indicating potential insolvency risks. The debt-to-equity ratio is not meaningful due to negative equity. The company is heavily reliant on debt, which poses financial stability risks.
Cash Flow
The cash flow statement shows a negative free cash flow consistently, indicating the company is burning cash without generating incoming cash flows. The operating cash flow to net income ratio is negative due to losses, highlighting unsustainable cash operations.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit-2.80K0.000.00-5.97K-60.83K-54.95K
EBITDA-10.72M-7.78M-3.99M-4.32M-1.04M-711.15K
Net Income-10.71M-9.14M-6.59M-5.00M-1.15M-805.73K
Balance Sheet
Total Assets3.54M2.51M5.95M8.65M651.64K544.05K
Cash, Cash Equivalents and Short-Term Investments2.09M1.92M5.46M8.42M504.75K117.15K
Total Debt667.33K1.17M1.09M748.30K978.88K874.28K
Total Liabilities2.15M1.80M1.90M975.68K2.28M2.23M
Stockholders Equity1.39M709.15K4.06M7.68M-1.63M-1.69M
Cash Flow
Free Cash Flow-11.20M-7.33M-5.60M-2.67M-300.34K-37.65K
Operating Cash Flow-11.20M-7.33M-5.58M-2.67M-300.34K-26.83K
Investing Cash Flow0.002.92M-2.83M0.000.00-10.82K
Financing Cash Flow13.14M3.76M2.57M10.58M687.93K70.07K

Shuttle Pharmaceuticals Holdings, Inc. Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.80
Price Trends
50DMA
2.01
Negative
100DMA
2.86
Negative
200DMA
4.16
Negative
Market Momentum
MACD
-0.02
Negative
RSI
47.23
Neutral
STOCH
38.53
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SHPH, the sentiment is Negative. The current price of 1.8 is above the 20-day moving average (MA) of 1.79, below the 50-day MA of 2.01, and below the 200-day MA of 4.16, indicating a neutral trend. The MACD of -0.02 indicates Negative momentum. The RSI at 47.23 is Neutral, neither overbought nor oversold. The STOCH value of 38.53 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for SHPH.

Shuttle Pharmaceuticals Holdings, Inc. Risk Analysis

Shuttle Pharmaceuticals Holdings, Inc. disclosed 59 risk factors in its most recent earnings report. Shuttle Pharmaceuticals Holdings, Inc. reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Shuttle Pharmaceuticals Holdings, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
$2.38M2.66%-27.81%
50
Neutral
$6.43M-1.72-76.14%25.02%55.11%
47
Neutral
$6.82M
43
Neutral
$3.33M
42
Neutral
$6.80M-1.31-42.47%-26.92%69.90%
32
Underperform
$2.89M-0.08-9999.00%79.31%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SHPH
Shuttle Pharmaceuticals Holdings, Inc.
1.80
-20.70
-92.00%
CPHI
China Pharma Holdings
1.36
-0.65
-32.59%
SNOA
Sonoma Pharmaceuticals
3.78
1.20
46.51%
RDHL
RedHill Biopharma
1.34
-4.23
-75.94%
PRFX
PainReform
0.85
-1.99
-70.11%
UPC
Universe Pharmaceuticals
4.22
-16.58
-79.71%

Shuttle Pharmaceuticals Holdings, Inc. Corporate Events

M&A TransactionsPrivate Placements and FinancingRegulatory Filings and Compliance
Shuttle Pharmaceuticals Accelerates Equity Payment in Asset Deal
Neutral
Dec 29, 2025

On December 23, 2025, Shuttle Pharmaceuticals Holdings, Inc. amended an existing asset purchase agreement involving its Canadian subsidiary 1563868 B.C. Ltd., Canadian seller 1542770 BC Ltd., and a seller guarantor, accelerating part of the first installment payment by issuing 320,496 shares of common stock. The transaction, which closed the same day, resulted in the seller receiving shares equal to 19.99% of Shuttle’s outstanding common stock at a deemed value of $1.76 per share, with the remaining portion of the first installment to be paid in cash under the original terms, signaling a material equity-based consideration structure executed under securities law exemptions for unregistered offerings.

Executive/Board Changes
Shuttle Pharmaceuticals CFO Resigns, Interim CEO Steps In
Neutral
Nov 28, 2025

On November 21, 2025, Shuttle Pharmaceuticals Holdings, Inc. announced the resignation of Timothy Lorber as Chief Financial Officer. In connection with his resignation, a Separation Agreement was established, allowing Mr. Lorber to provide part-time services until December 4, 2025, and remain available for consultation until February 8, 2026. Christopher Cooper, the Interim CEO, has taken over the CFO role while the company searches for a permanent replacement. The agreement includes a retention bonus for Mr. Lorber and the vesting of restricted stock units, reflecting a structured transition plan.

Business Operations and StrategyM&A Transactions
Shuttle Pharmaceuticals Completes Strategic Asset Acquisition
Positive
Nov 26, 2025

On November 20, 2025, Shuttle Pharmaceuticals Holdings, Inc. finalized an Asset Purchase Agreement with its subsidiary and other parties, acquiring substantial assets and liabilities from a Canadian corporation. The transaction involved a cash payment of $3 million on the closing date, with additional payments and potential milestone-based contributions outlined in the agreement. This strategic acquisition is expected to enhance Shuttle Pharmaceuticals’ capabilities in drug discovery, leveraging advanced AI models to accelerate the process, which may strengthen its position in the pharmaceutical industry.

Business Operations and StrategyLegal Proceedings
Shuttle Pharmaceuticals Faces Agreement Termination and Settlement
Negative
Nov 21, 2025

On October 15, 2025, Shuttle Pharmaceuticals Holdings, Inc. received a termination notice from Theradex Systems, Inc. regarding their master agreement, leading to a settlement where Shuttle Pharmaceuticals will pay $300,000 to Theradex to settle outstanding liabilities. Consequently, Shuttle Pharmaceuticals has decided to discontinue its clinical trials of Ropidoxuridine, expecting to incur additional expenses related to trial closeout activities, with most charges anticipated in the fourth quarter of 2025.

Delistings and Listing ChangesPrivate Placements and FinancingRegulatory Filings and Compliance
Shuttle Pharmaceuticals Regains Compliance with Nasdaq
Neutral
Nov 17, 2025

Shuttle Pharmaceuticals Holdings, Inc. reported a stockholders’ equity of $1,394,161 for the quarter ended September 30, 2025, falling short of the Nasdaq’s requirement of $2,500,000. However, the company believes it has regained compliance following a private placement on November 4, 2025, which raised approximately $2.5 million. Nasdaq will continue to monitor the company’s compliance, and failure to maintain the required equity could result in delisting.

Private Placements and FinancingRegulatory Filings and Compliance
Shuttle Pharmaceuticals Raises $2.5 Million in Private Placement
Neutral
Nov 7, 2025

On November 3, 2025, Shuttle Pharmaceuticals Holdings, Inc. entered into a securities purchase agreement to issue and sell a pre-funded warrant for 625,156 shares of common stock, raising approximately $2.5 million in a private placement. The offering closed on November 4, 2025, and includes provisions for the exercise of the warrant and filing of a registration statement with the SEC. The transaction was facilitated by WestPark Capital, Inc. as the placement agent, with the company agreeing to certain restrictions on issuing additional shares for a period following the offering.

Business Operations and StrategyM&A Transactions
Shuttle Pharmaceuticals Acquires Molecule’s Assets for $10M
Negative
Oct 21, 2025

On October 20, 2025, Shuttle Pharmaceuticals Holdings, Inc. entered into a binding term sheet with 1542770 BC Ltd. to acquire substantially all of Molecule’s assets and liabilities for $10 million, payable in cash and company stock, contingent on certain milestones. Earlier, on October 15, 2025, Shuttle received a termination notice from Theradex Systems, Inc., its primary contract research organization, demanding payment of $1.091 million and threatening to cease services if unpaid within 30 days, highlighting potential operational disruptions.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 24, 2025