Analysts Offer Insights on Healthcare Companies: PepGen Inc. (NASDAQ: PEPG), Cullinan Management (NASDAQ: CGEM) and aTyr Pharma (NASDAQ: ATYR)We saw 12.3% and 29.1% splicing correction for 5 mg/kg and 10 mg/kg, respectively, that was accompanied by some early trends in 10-meter walk/run test (10MWRT) and myotonia measured by video hand opening time (vHOT), already approaching levels that were seen with 6 and 12 months of repeat dosing with the assets from RNA (OP) and DYN (Not Rated), which we think bodes well for repeat dosing. Importantly, PEPG's approach in DM1 is differentiated from RNA and DYN, which we think has the potential to drive greater efficacy over time. PGN-EDODM1 is a peptide-conjugated ASO designed to bind only to mutant DMPK mRNA transcripts to block the toxic CUG repeat, thereby reducing the toxic nuclear foci while leaving wild-type DMPK intact, while RNA's del-desiran and DYN's DYNE-101 both target all DMPK for degradation (see here and here).