Combination Therapy FeasibilityA favorable safety profile and a drug-drug interaction study supporting coadministration with osimertinib and lorlatinib increase the feasibility of combining NXP900 with standard targeted backbones.
Market Opportunity And Trial DesignBroad combo-enrollment criteria that do not require specific genetic alterations expand the eligible patient pool in the fragmented non-small-cell lung cancer landscape with limited targeted options.
Mechanism Of ActionNXP900's ability to lock YES1/YAP1 in an inactive form targets Hippo pathway dysregulation and could resensitize EGFR- and ALK-resistant tumors to existing therapies.