Want to see PYXS full AI Analyst Report?
PYXS Stock Chart & Stats
$2.61
$0.30(11.49%)
At close: 4:00 PM EDT
$2.61
$0.30(11.49%)
Day’s Range― - ―
52-Week Range$0.97 - $5.55
Previous CloseN/A
Volume197.33K
Average Volume (3M)757.02K
Market Cap
$167.89M
Enterprise Value$68.43
Total Cash (Recent Filing)$42.49M
Total Debt (Recent Filing)$18.26M
Price to Earnings (P/E)―
Beta1.41
Next Earnings
Aug 19, 2026EPS Estimate
-0.35Next Dividend Ex-DateN/A
Dividend YieldN/A
Share Statistics
EPS (TTM)-1.31
Shares Outstanding63,355,480
10 Day Avg. Volume789,983
30 Day Avg. Volume757,017
Financial Highlights & Ratios
PEG Ratio0.30
Price to Book (P/B)1.34
Price to Sales (P/S)5.16
P/FCF Ratio-1.13
Enterprise Value/Market Cap<0.01
Enterprise Value/Revenue<0.01
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$7.29Price Target Upside179.15% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering8
EPS Forecast (FY)-1.22
Revenue Forecast (FY)$66.67K
Bulls Say, Bears Say
Bulls Say
Extended Cash Runway From Private PlacementThe ~$50M upfront financing (with up to $64M via warrants) extends cash runway into Q2 2027, enabling continued clinical development and planned MICVO readouts. This reduces immediate fundraising pressure and allows management to prioritize data generation over urgent capital raises for the next 8–12 months.
Focused Antibody/ADC Immuno-oncology PipelinePyxis's strategy centers on antibody therapeutics and ADCs in immuno-oncology, a structural growth area with high unmet need. A focused clinical-stage portfolio concentrates resources on a few programs (eg, MICVO), creating clear milestone-driven value inflection opportunities if mid-stage data validate mechanisms.
Strengthened Governance And Audit OversightApproval of directors and Ernst & Young as auditor reinforces board continuity and independent financial oversight. Strong governance and credible external audit support disciplined capital allocation and reliable reporting, which matter for sponsor/partner diligence and long-term strategic execution in clinical-stage biotech.
Bears Say
High And Persistent Cash BurnSustained TTM operating and free cash flow near -$67M demonstrates chronic cash consumption tied to R&D and trials. Ongoing negative cash generation necessitates recurring financings, elevates dilution risk, and constrains the company's ability to advance multiple programs or scale operations without external capital or partnering.
Shrinking Equity Base And Contracted AssetsA sharp contraction in shareholders' equity and total assets reduces the balance-sheet buffer available for setbacks. Lower book equity limits financial flexibility, increases reliance on markets or partners for funding, and heightens vulnerability to trial delays, unexpected costs, or adverse data.
Revenue Decline And Non-recurring MixReported revenue (~$13.9M TTM) dropped versus prior year and is described as driven by one-off licensing/milestone items. Lack of recurring commercial revenue means the company cannot self-fund development long-term, making progress heavily dependent on successful clinical outcomes or partner deals to create sustainable cash flow.
Pyxis Oncology News
PYXS FAQ
What was Pyxis Oncology’s price range in the past 12 months?
Pyxis Oncology lowest stock price was $0.97 and its highest was $5.55 in the past 12 months.
What is Pyxis Oncology’s market cap?
Pyxis Oncology’s market cap is $167.89M.
When is Pyxis Oncology’s upcoming earnings report date?
Pyxis Oncology’s upcoming earnings report date is Aug 19, 2026 which is in 13 days.
How were Pyxis Oncology’s earnings last quarter?
Pyxis Oncology released its earnings results on May 14, 2026. The company reported -$0.37 earnings per share for the quarter, missing the consensus estimate of -$0.364 by -$0.006.
Is Pyxis Oncology overvalued?
According to Wall Street analysts Pyxis Oncology’s price is currently Undervalued.
Does Pyxis Oncology pay dividends?
Pyxis Oncology does not currently pay dividends.
What is Pyxis Oncology’s EPS estimate?
Pyxis Oncology’s EPS estimate is -0.35.
How many shares outstanding does Pyxis Oncology have?
Pyxis Oncology has 63,355,480 shares outstanding.
What happened to Pyxis Oncology’s price movement after its last earnings report?
Pyxis Oncology reported an EPS of -$0.37 in its last earnings report, missing expectations of -$0.364. Following the earnings report the stock price went down -15.649%.
Which hedge fund is a major shareholder of Pyxis Oncology?
Currently, no hedge funds are holding shares in PYXS
What is the TipRanks Smart Score and how is it calculated?
Smart Score combines eight research factors - such as analyst recommendations, hedge fund trends, and technical indicators - to measure a stock’s outlook. These signals are unified into a single score that reflects bullish or bearish momentum. See detailed methodology
Pyxis Oncology Stock Smart Score
Outperform
1
2
3
4
5
6
7
8
9
10
Analyst Consensus
Strong Buy
Average Price Target:
$7.29 (179.15% Upside)
$7.29 (179.15% Upside)
Hedge Fund Trend
Decreased
By 161.2K Shares
Last Quarter.
Last Quarter.
Crowd Wisdom
Very Positive
Last 7 Days ▲ 2.2%
Last 30 Days ▲ 9.4%
Last 30 Days ▲ 9.4%
News Sentiment
Very Bullish
Bullish news 100%
Bearish news 0%
Bearish news 0%
Technicals
SMA
Positive
20 days / 200 days
Momentum
148.23%
12-Months-Change
Fundamentals
Return on Equity
―
Trailing 12-Months
Asset Growth
-52.67%
Trailing 12-Months
Company Description
Pyxis Oncology
Pyxis Oncology, Inc. operates as a preclinical biopharmaceutical company focused on developing novel therapeutic approaches to combat various forms of cancer. Its investigational immune-oncology pipeline includes PYX-106, a fully human immunoglobulin G1 (IgG1) antibody designed to target siglec-15, which is being explored for its potential efficacy against thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors. Additionally, PYX-102 is an immune-therapeutic currently under investigation for the treatment of solid tumors. The company's portfolio also features a range of investigational antibody-drug conjugate (ADC) candidates: PYX-201, a novel ADC being developed for NSCLC, breast cancer, and other solid tumors; PYX-202, another novel ADC aimed at small cell lung cancer (SCLC), soft tissue sarcoma, and other solid tumors; and PYX-203, an ADC undergoing evaluation for acute myeloid leukemia and myeloid dysplastic syndrome. Pyxis Oncology was founded in 2018 and is based in Cambridge, Massachusetts.
PYXS Stock 12 Month Forecast
Average Price Target
$7.29
▲(179.15% Upside)
Technical Analysis
Nkarta
―
Greenwich LifeSciences
―
Elicio Therapeutics
―
Biomea Fusion
―
Nuvectis Pharma
―
Ownership Overview
2.81% Insiders
4.05% Mutual Funds
1.62% Other Institutional Investors
87.45% Public Companies and
Individual Investors










