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PYXS Stock Chart & Stats
$1.66
-$0.10(-5.75%)
At close: 4:00 PM EST
$1.66
-$0.10(-5.75%)
Day’s Range― - ―
52-Week Range$0.97 - $5.55
Previous CloseN/A
Volume258.73K
Average Volume (3M)757.02K
Market Cap
$169.16M
Enterprise Value$131.39M
Total Cash (Recent Filing)$42.49M
Total Debt (Recent Filing)$18.26M
Price to Earnings (P/E)―
Beta1.31
Next Earnings
Aug 19, 2026EPS Estimate
-0.34Next Dividend Ex-DateN/A
Dividend YieldN/A
Share Statistics
EPS (TTM)-1.31
Shares Outstanding63,355,480
10 Day Avg. Volume789,983
30 Day Avg. Volume757,017
Financial Highlights & Ratios
PEG Ratio0.30
Price to Book (P/B)1.34
Price to Sales (P/S)5.16
P/FCF Ratio-1.13
Enterprise Value/Market Cap0.78
Enterprise Value/Revenue9.48
Enterprise Value/Gross Profit9.50
Enterprise Value/Ebitda-1.73
Forecast
1Y Price Target
$6.50Price Target Upside291.57% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering7
EPS Forecast (FY)-1.21
Revenue Forecast (FY)$58.33K
Bulls Say, Bears Say
Bulls Say
Private Placement Extends RunwayThe ~$50M private placement meaningfully extends near-term liquidity into Q2 2027, allowing continued execution of clinical development and data readouts without immediate fundraising. This reduces short-term existential risk and gives management time to advance MICVO trials and generate value-driving clinical milestones.
Focused Antibody/ADC PipelinePyxis’s concentrated strategy on antibody therapeutics and ADCs in immuno-oncology is a durable business model advantage: specialized expertise and platform continuity increase the chance to translate trial success into multiple indications, allow efficient allocation of R&D spend, and attract targeted partner interest over time.
Moderate Balance-sheet LeverageHeadline leverage of ~0.35 indicates manageable debt obligations for a clinical-stage biotech, limiting fixed servicing demands. With modest borrowings, the company has more flexibility to prioritize R&D investment and absorb near-term revenue variability, reducing insolvency risk relative to highly leveraged peers.
Bears Say
Persistent Heavy Cash BurnSustained negative operating and free cash flow (~-$67M TTM) shows structural cash consumption from R&D and operations. Absent successful partnerships, product approvals, or recurring revenue, the company will remain reliant on capital markets to fund operations, increasing dilution risk and creating ongoing financing execution risk.
Contracting Equity BaseA sharp decline in shareholders' equity over several years reflects accumulated losses and prior financings, reducing the balance-sheet cushion. A smaller equity base limits borrowing capacity, amplifies dilution from future raises, and weakens the firm’s ability to absorb clinical setbacks or fund opportunistic investments without costly capital raises.
Small, Declining Revenue And Deep LossesRevenue remains modest and fell year-over-year while net losses are substantial (~-$81.7M TTM), producing very negative margins. This structural gap between limited commercial revenue and high operating costs means path to self-sustaining operations depends heavily on successful clinical outcomes or partnerships, increasing execution risk.
Pyxis Oncology News
PYXS FAQ
What was Pyxis Oncology’s price range in the past 12 months?
Pyxis Oncology lowest stock price was $0.97 and its highest was $5.55 in the past 12 months.
What is Pyxis Oncology’s market cap?
Pyxis Oncology’s market cap is $169.16M.
When is Pyxis Oncology’s upcoming earnings report date?
Pyxis Oncology’s upcoming earnings report date is Aug 19, 2026 which is in 37 days.
How were Pyxis Oncology’s earnings last quarter?
Pyxis Oncology released its earnings results on May 14, 2026. The company reported -$0.37 earnings per share for the quarter, missing the consensus estimate of -$0.364 by -$0.006.
Is Pyxis Oncology overvalued?
According to Wall Street analysts Pyxis Oncology’s price is currently Undervalued.
Does Pyxis Oncology pay dividends?
Pyxis Oncology does not currently pay dividends.
What is Pyxis Oncology’s EPS estimate?
Pyxis Oncology’s EPS estimate is -0.34.
How many shares outstanding does Pyxis Oncology have?
Pyxis Oncology has 63,355,480 shares outstanding.
What happened to Pyxis Oncology’s price movement after its last earnings report?
Pyxis Oncology reported an EPS of -$0.37 in its last earnings report, missing expectations of -$0.364. Following the earnings report the stock price went down -15.649%.
Which hedge fund is a major shareholder of Pyxis Oncology?
Currently, no hedge funds are holding shares in PYXS
What is the TipRanks Smart Score and how is it calculated?
Smart Score combines eight research factors - such as analyst recommendations, hedge fund trends, and technical indicators - to measure a stock’s outlook. These signals are unified into a single score that reflects bullish or bearish momentum. See detailed methodology
Pyxis Oncology Stock Smart Score
Outperform
1
2
3
4
5
6
7
8
9
10
Analyst Consensus
Strong Buy
Average Price Target:
$6.50 (291.57% Upside)
$6.50 (291.57% Upside)
Hedge Fund Trend
Decreased
By 161.2K Shares
Last Quarter.
Last Quarter.
Crowd Wisdom
Positive
Last 7 Days ▲ 2.6%
Last 30 Days ▼ 1.6%
Last 30 Days ▼ 1.6%
News Sentiment
Neutral
Bullish news 50%
Bearish news 50%
Bearish news 50%
Technicals
SMA
Positive
20 days / 200 days
Momentum
148.23%
12-Months-Change
Fundamentals
Return on Equity
-135.60%
Trailing 12-Months
Asset Growth
-52.67%
Trailing 12-Months
Company Description
Pyxis Oncology
Pyxis Oncology, Inc. operates as a preclinical biopharmaceutical company focused on developing novel therapeutic approaches to combat various forms of cancer. Its investigational immune-oncology pipeline includes PYX-106, a fully human immunoglobulin G1 (IgG1) antibody designed to target siglec-15, which is being explored for its potential efficacy against thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors. Additionally, PYX-102 is an immune-therapeutic currently under investigation for the treatment of solid tumors. The company's portfolio also features a range of investigational antibody-drug conjugate (ADC) candidates: PYX-201, a novel ADC being developed for NSCLC, breast cancer, and other solid tumors; PYX-202, another novel ADC aimed at small cell lung cancer (SCLC), soft tissue sarcoma, and other solid tumors; and PYX-203, an ADC undergoing evaluation for acute myeloid leukemia and myeloid dysplastic syndrome. Pyxis Oncology was founded in 2018 and is based in Cambridge, Massachusetts.
PYXS Stock 12 Month Forecast
Average Price Target
$6.50
▲(291.57% Upside)
Technical Analysis
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Ownership Overview
2.81% Insiders
4.05% Mutual Funds
31.69% Other Institutional Investors
57.30% Public Companies and
Individual Investors










