Clinical Design And Preclinical ValidationCR-001's VEGF x PD-1 bispecific design mirrors a leading comparator and shows cooperative binding and strong T-cell activation in preclinical studies, supporting potential meaningful anti-tumor activity.
Partnership And Strategic FundingPartnership and cross-licensing with Kelun Biotech, including upfront financing, extends development runway, enables parallel ex-China and China programs, and reduces near-term financing risk.
Regulatory And Clinical DevelopmentInvestigational New Drug clearance in the United States for CR-001 and a planned global Phase one/two ASCEND study across multiple tumor types increase prospects for early human safety and proof-of-concept data.