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Nautilus Biotechnolgy (NAUT)
NASDAQ:NAUT
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Nautilus Biotechnolgy (NAUT) AI Stock Analysis

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NAUT

Nautilus Biotechnolgy

(NASDAQ:NAUT)

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Neutral 41 (OpenAI - 4o)
Rating:41Neutral
Price Target:
Nautilus Biotechnology's score reflects its early-stage status with high operational losses and zero revenue, typical for biotech firms focused on R&D. While its strong cash reserves and low leverage offer some stability, persistent losses and slow pharma partnerships pose significant risks. Technical indicators suggest a bearish trend, but the earnings call highlighted positive advancements in proteomics and cost efficiencies, offering a cautiously optimistic outlook.
Positive Factors
Technological Advancements
Nautilus's advancements in proteomics technology enhance its competitive edge, potentially accelerating drug discovery and diagnostics, which is crucial for long-term growth in the biotech sector.
Strong Cash Position
A robust cash position provides Nautilus with the financial flexibility to continue R&D efforts and sustain operations, crucial for biotech firms in the development phase.
Cost Efficiency
The reduction in operating expenses reflects effective cost management, which can extend the company's financial runway and support sustainable growth.
Negative Factors
Zero Revenue
The absence of revenue highlights the company's reliance on future product launches and partnerships, posing a risk to financial sustainability if commercialization is delayed.
Operational Losses
Ongoing operational losses indicate financial strain, which could limit the company's ability to invest in growth initiatives and impact long-term viability.
Slow Pharma Partnerships
Delayed partnerships with pharma companies could hinder Nautilus's market penetration and revenue generation, affecting its strategic growth plans.

Nautilus Biotechnolgy (NAUT) vs. SPDR S&P 500 ETF (SPY)

Nautilus Biotechnolgy Business Overview & Revenue Model

Company DescriptionNautilus Biotechnology, Inc., a development stage life sciences company, engages in creating a platform technology for quantifying and unlocking the complexity of the proteome. It develops Nautilus Platform, a proteomics platform that includes end-to-end solution comprised of instruments, consumables, and software analysis. The company was founded in 2016 and is headquartered in Seattle, Washington.
How the Company Makes MoneyNautilus Biotechnology generates revenue primarily through the commercialization of its proteomics platform. The company offers its technology to pharmaceutical companies, academic institutions, and research organizations, which use it to conduct detailed protein analysis. Key revenue streams include the sale of instruments, consumables, and related services required to operate the platform. Additionally, Nautilus may engage in strategic partnerships and collaborations with other entities in the biotech and pharmaceutical industries, which can provide further revenue through joint research projects, licensing agreements, and milestone payments based on the successful achievement of specific research or development goals.

Nautilus Biotechnolgy Earnings Call Summary

Earnings Call Date:Oct 28, 2025
(Q3-2025)
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% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Positive
The call emphasized significant scientific and operational progress, expansion of strategic partnerships, and positive market feedback, tempered by the acknowledgment of limited near-term revenue expectations.
Q3-2025 Updates
Positive Updates
Scientific Platform Progress
Meaningful progress in scientific platform with the publication of a preprint showcasing the iterative mapping method and new collaborations with renowned institutes like the Neuro Stem Cell Institute, Mount Sinai Medical Center, and the Allen Institute for Brain Science.
Partnership with Buck Institute
Collaboration with the Buck Institute for Research on Aging to examine Tau proteoforms related to Alzheimer's disease, with results to be presented at the Human Proteome Organization's World HUPO Conference.
Expansion of Collaborator Pipeline
Significant expansion of potential collaborators, including academic centers, nonprofit institutes, and biopharma companies, interested in exploring proteoform-based precision biomarkers.
Market Research and Customer Insights
Completion of market study involving over 250 decision-makers, highlighting Nautilus platform's competitive differentiation and strong market fit with willingness to pay a premium for the solution.
Financial Discipline and Cash Runway
Reduction in operating expenses by 19% year-over-year, with a cash runway extending through 2027, reflecting strong financial discipline.
Negative Updates
Limited Near-term Revenue
Expectation of limited revenue in the near term from early engagements, as the focus is on generating high-quality data and validating the platform.
Company Guidance
In the third quarter of 2025, Nautilus Biotechnology provided guidance on their operational and financial progress, focusing on their path towards commercialization. They reported total operating expenses of $15.5 million, reflecting a 19% year-over-year decrease due to improved operating efficiency and lower development costs. The company ended the quarter with $168.5 million in cash, cash equivalents, and investments, and a cash burn of $11.0 million, projecting a cash runway extending through 2027. Nautilus emphasized their strategic collaborations, including partnerships with the Buck Institute for Research on Aging and the Allen Institute for Brain Science, to explore proteoform-based biomarkers for neurodegenerative diseases. The company plans to launch their early access program for the Tau proteoform assay in the first half of 2026, with limited revenue expected initially, but significant potential for future commercial opportunities. Nautilus is also progressing towards the broadscale commercial launch of their platform in late 2026, following promising early results from their new assay configuration.

Nautilus Biotechnolgy Financial Statement Overview

Summary
Nautilus Biotechnology is in an early growth phase with consistent zero revenue and significant net losses, typical for biotech startups. Strong cash reserves and low leverage offer some financial stability, but the ongoing operational losses and cash outflows pose significant risks.
Income Statement
15
Very Negative
Nautilus Biotechnology has consistently reported zero revenue, reflecting its early-stage development status typical for biotech firms. The company faces significant net losses, with a negative net profit margin and no gross profit. Revenue growth is non-existent, while operating expenses remain high, adversely affecting EBIT and EBITDA margins.
Balance Sheet
30
Negative
The balance sheet shows a relatively strong equity position with a consistent decrease in stockholders' equity over recent years, reflecting ongoing losses. The debt-to-equity ratio is favorable, indicating low leverage, but the negative equity in earlier years signals financial instability. The equity ratio is reasonably high, suggesting a good proportion of assets financed by equity.
Cash Flow
20
Very Negative
The cash flow statement reveals negative free cash flow and operating cash flow, reflecting high cash burn typical for biotech startups. The free cash flow to net income ratio is negative, indicating cash outflows exceed inflows. However, substantial cash reserves provide a buffer against short-term financial challenges.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue9.60M0.000.000.000.000.00
Gross Profit4.80M-6.35M-5.71M-3.42M-2.84M-2.35M
EBITDA-64.24M-64.43M-74.30M-60.20M-47.66M-13.40M
Net Income-62.81M-70.78M-63.67M-57.92M-50.31M-15.62M
Balance Sheet
Total Assets200.91M242.74M305.56M350.05M398.45M85.01M
Cash, Cash Equivalents and Short-Term Investments131.43M129.89M173.42M184.47M345.73M76.74M
Total Debt27.00M30.48M34.63M30.33M30.03M4.78M
Total Liabilities31.78M34.01M40.21M35.13M34.87M114.73M
Stockholders Equity169.14M208.73M265.35M314.92M363.58M-29.72M
Cash Flow
Free Cash Flow-53.92M-61.27M-54.15M-48.13M-41.51M-14.92M
Operating Cash Flow-52.63M-59.15M-51.71M-45.81M-39.24M-14.00M
Investing Cash Flow71.54M66.25M-43.73M-25.74M-138.96M-25.28M
Financing Cash Flow553.00K1.14M368.00K562.00K327.45M75.90M

Nautilus Biotechnolgy Technical Analysis

Technical Analysis Sentiment
Positive
Last Price1.66
Price Trends
50DMA
1.02
Positive
100DMA
0.88
Positive
200DMA
0.95
Positive
Market Momentum
MACD
0.18
Negative
RSI
63.31
Neutral
STOCH
55.93
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For NAUT, the sentiment is Positive. The current price of 1.66 is above the 20-day moving average (MA) of 1.39, above the 50-day MA of 1.02, and above the 200-day MA of 0.95, indicating a bullish trend. The MACD of 0.18 indicates Negative momentum. The RSI at 63.31 is Neutral, neither overbought nor oversold. The STOCH value of 55.93 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for NAUT.

Nautilus Biotechnolgy Risk Analysis

Nautilus Biotechnolgy disclosed 69 risk factors in its most recent earnings report. Nautilus Biotechnolgy reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Nautilus Biotechnolgy Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
55
Neutral
$122.42M-33.00%54.91%
54
Neutral
$122.17M-1.58-25.74%13.77%-4.76%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
$89.81M-0.55-222.28%1.80%
41
Neutral
$200.83M-3.19-32.00%11.15%
36
Underperform
$114.48M-0.87-75.71%-103.31%
28
Underperform
$78.83M-0.62-50.68%73.18%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
NAUT
Nautilus Biotechnolgy
1.66
-0.83
-33.33%
VTGN
VistaGen Therapeutics
4.03
1.10
37.54%
ADVM
Adverum Biotechnologies
4.33
-3.56
-45.12%
KLRS
Kalaris Therapeutics
5.07
-7.38
-59.28%
SEER
Seer
2.07
-0.19
-8.41%
ABOS
Acumen Pharmaceuticals
1.97
-0.71
-26.49%

Nautilus Biotechnolgy Corporate Events

Executive/Board ChangesBusiness Operations and StrategyFinancial Disclosures
Nautilus Biotechnology Announces Board Changes for 2025
Negative
Feb 27, 2025

Nautilus Biotechnology announced changes in its board of directors for the 2025 annual meeting, with Vijay Pande and Michael Altman stepping down, and Matthew McIlwain transitioning to a Class I director to maintain board balance. The company also reported its financial results for the fourth quarter and fiscal year 2024, highlighting a slight increase in operating expenses and a net loss compared to the previous year. Nautilus plans to launch its proteome analysis platform in late 2026 and has reduced its workforce by 16% to align resources with development goals, aiming to extend its cash runway through 2027.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 30, 2025