Commercial OpportunityRecent trial results indicate the drug's role in the targeted skin disease market may be smaller than previously expected, which could limit its commercial upside.
Pivotal Trial FailureFailure of a pivotal late-stage trial to meet its primary endpoint, driven partly by an unexpectedly high placebo response, raises material doubt about the drug's likelihood of regulatory approval.
Valuation RiskInvestor enthusiasm following mid-stage results appears to have pushed the share price beyond the strength of the clinical evidence, increasing downside risk if upcoming readouts are mixed or negative.