Competitive ConcernsThere are competitive concerns over low-cost, similarly effective GLP-1s and more potent FGF21s expected to launch, which could impact Madrigal's market position.
Prescriber SkepticismBroad prescriber headwinds exist, including skepticism about MASH and administrative challenges like access to FibroScans.
Pricing And Guidance UncertaintyUncertainties and pricing-related headwinds may lead to a cautious approach in providing long-term guidance, despite expectations of strong growth.