Lyra Therapeutics, Inc. (LYRA)
OTHER OTC:LYRA
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Lyra Therapeutics
(OTC:LYRA)
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Rating:40Underperform
Price Target:
$0.57
▼(-71.21% Downside)
Action:Reiterated
Date:06/11/26
The score is driven primarily by weak financial fundamentals (minimal revenue, ongoing losses/cash burn, and negative equity) and significant negative corporate events (Nasdaq delisting and restructuring-related lease termination costs). Technicals also reflect a downtrend, while valuation signals are limited due to a negative P/E and no dividend support.
Positive Factors
Proprietary drug-delivery technology
Lyra’s focused platform for localized, long‑acting sinonasal drug delivery is a durable competitive asset. Controlled‑release implants can enable longer dosing intervals and differentiation in ENT indications, creating higher clinical and commercial entry barriers if clinical programs succeed.
Negative Factors
Weakened balance sheet; negative equity
Negative shareholders’ equity and elevated debt relative to assets are persistent structural weaknesses. This erodes financial flexibility, raises insolvency risk if losses continue, and constrains the company’s ability to secure favorable financing or withstand further clinical or commercial setbacks.
Read all positive and negative factors
Positive Factors
Negative Factors
Proprietary drug-delivery technology
Lyra’s focused platform for localized, long‑acting sinonasal drug delivery is a durable competitive asset. Controlled‑release implants can enable longer dosing intervals and differentiation in ENT indications, creating higher clinical and commercial entry barriers if clinical programs succeed.
Read all positive factors
Lyra Therapeutics (LYRA) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$976.18K
Dividend YieldN/A
Average Volume (3M)9.85K
Price to Earnings (P/E)―
Beta (1Y)3.46
Revenue Growth-74.05%
EPS Growth73.08%
CountryUS
Employees30
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-18.62
Shares Outstanding1,774,882
10 Day Avg. Volume6,177
30 Day Avg. Volume9,854
Financial Highlights & Ratios
PEG Ratio>-0.01
Price to Book (P/B)-4.46
Price to Sales (P/S)120.22
P/FCF Ratio-1.65
Enterprise Value/Market Cap15.52
Enterprise Value/Revenue38.06
Enterprise Value/Gross Profit38.06
Enterprise Value/Ebitda-0.55
Forecast
1Y Price TargetN/A
Price Target UpsideN/A
Rating ConsensusN/A
Number of Analyst Covering0
EPS Forecast (FY)-0.99
Revenue Forecast (FY)$2.70M
Lyra Therapeutics Business Overview & Revenue Model
Company Description
Lyra Therapeutics, Inc. operates as a clinical-stage biotechnology company, primarily focused on the creation and commercialization of anti-inflammatory treatments for individuals suffering from chronic rhinosinusitis (CRS). The company's unique t...
How the Company Makes Money
As a clinical-stage biotechnology company, Lyra Therapeutics has not historically relied on recurring product sales as a primary source of revenue. Publicly available information indicating material, ongoing commercial revenue from marketed produc...
Lyra Therapeutics Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
22
Negative
Cash Flow
20
Very Negative
| Breakdown | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 398.00K | 1.53M | 1.56M | 1.36M | 285.00K |
| Gross Profit | 398.00K | 1.53M | 1.56M | 1.36M | -29.41M |
| EBITDA | -29.09M | -60.26M | -65.25M | -53.92M | -42.61M |
| Net Income | -28.92M | -93.44M | -62.68M | -55.28M | -43.51M |
Balance Sheet | |||||
| Total Assets | 36.11M | 66.35M | 142.60M | 109.97M | 54.87M |
| Cash, Cash Equivalents and Short-Term Investments | 15.89M | 40.58M | 102.75M | 97.89M | 45.75M |
| Total Debt | 30.26M | 34.38M | 26.88M | 4.18M | 1.45M |
| Total Liabilities | 46.83M | 54.75M | 53.18M | 29.21M | 20.55M |
| Stockholders Equity | -10.72M | 11.59M | 89.42M | 80.75M | 34.32M |
Cash Flow | |||||
| Free Cash Flow | -28.98M | -72.35M | -64.35M | -43.55M | -29.20M |
| Operating Cash Flow | -28.86M | -70.01M | -63.30M | -43.38M | -25.82M |
| Investing Cash Flow | -98.00K | 80.31M | -12.58M | -65.01M | -3.38M |
| Financing Cash Flow | 4.27M | 8.53M | 65.69M | 96.26M | 359.00K |
Lyra Therapeutics Technical Analysis
Negative
1.98
Price Trends
0.69
Negative
0.98
Negative
3.04
Negative
Market Momentum
-0.03
Positive
37.95
Neutral
13.33
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LYRA, the sentiment is Negative. The current price of 1.98 is above the 20-day moving average (MA) of 0.69, above the 50-day MA of 0.69, and below the 200-day MA of 3.04, indicating a bearish trend. The MACD of -0.03 indicates Positive momentum. The RSI at 37.95 is Neutral, neither overbought nor oversold. The STOCH value of 13.33 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for LYRA.
Lyra Therapeutics Risk Analysis
Lyra Therapeutics disclosed 24 risk factors in its most recent earnings report. Lyra Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Lyra Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
40 Underperform | $976.18K | -0.24 | 1211.14% | ― | -74.05% | 73.08% | |
| ― | $5.51M | -3.81 | ― | ― | ― | ― | |
49 Neutral | $5.07M | -0.12 | -684.86% | ― | ― | 95.40% | |
43 Neutral | $5.61M | -1.83 | -418.83% | ― | ― | 97.67% | |
42 Neutral | $1.31M | -0.08 | -529.06% | ― | ― | 96.81% | |
40 Underperform | $8.76M | -0.29 | -97.58% | ― | 78.64% | 50.70% |
* Healthcare Sector Average
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Lyra Therapeutics Corporate Events
Business Operations and Strategy
Lyra Therapeutics Ends Major Office Sublease Agreement
Negative
Apr 17, 2026
On April 13, 2026, Lyra Therapeutics, Inc. agreed with RVAC Medicines (US), Inc. to terminate its sublease for about 23,704 rentable square feet at 880 Winter Street in Waltham, Massachusetts, originally signed on December 21, 2023. The sublease t...
Business Operations and Strategy
Lyra Therapeutics Streamlines Operations with Major Lease Terminations
Negative
Apr 10, 2026
On March 31, 2026, Lyra Therapeutics, Inc. agreed to terminate its lease for 22,343 rentable square feet at 480 Arsenal Way in Watertown, Massachusetts, which had been scheduled to run until April 30, 2027. The lease will now end no later than May...
Delistings and Listing Changes
Lyra Therapeutics Withdraws Nasdaq Appeal, Faces Imminent Delisting
Negative
Mar 16, 2026
On March 13, 2026, Lyra Therapeutics, Inc. disclosed that it received confirmation from Nasdaq that the company has withdrawn its appeal of a February 2, 2026 delisting determination. As a result of this withdrawal, trading in Lyra’s common ...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.