Strong Revenue and Rapid Quarter-over-Quarter Growth
Full-year 2025 YUTREPIA net product sales of $148.3M; Q4 2025 sales of $90.1M. Management reported Q4 growth versus Q3 of 2025 at ~74% (also referenced as ~80% QoQ increase in commentary).
Profitability and Cash Generation
Q4 2025 non-GAAP adjusted EBITDA of $27.3M and net income of $14.6M. Company generated $33M positive operating cash flow in Q4 and ended the year with ~$190.7M in cash and cash equivalents.
Rapid Commercial Launch and Patient Momentum
Since launch (9 months) >3,600 unique patient referrals and therapy shipped for >2,900 patients (through Feb 28, 2026). Patient starts composition: ~75% prostacyclin-naive and ~25% transitions.
Market Share Gains in Inhaled Treprostinil
Company estimates inhaled treprostinil quarter revenue was ~ $550M in Q4 and reports its revenue share grew from ~10% in Q3 2025 to ~17% in Q4 2025, indicating meaningful QoQ share gains and capturing disproportionate new patient starts.
High Prescriber Engagement and Pull-Through
Total prescribers increased to ~860; ~25% of clinicians have referred 5+ patients. Prescription-to-patient start conversion (pull-through) reported above 85%.
Clinical Differentiation and Evidence Generation
Management emphasized YUTREPIA's differentiated profile (deep-lung delivery, low-effort device, wide dose range), SENSE/ASCENT data showing tolerability and ability to dose 2–4x prior standards without cough exacerbation, and plans to initiate multiple new studies (transition studies, sotatercept adjunctive studies, PH-COPD, systemic sclerosis–associated Raynaud's phenomenon).
Strategic Growth Plans and Next-Generation Program
Company plans to expand commercial team by ~1/3, pursue label- and market-expanding studies, initiate a pivotal study for next-generation L606 (liposomal, twice-daily formulation) with enrollment expected in upcoming quarters, and targets a path to a $1B franchise by 2027.