Patent Litigation RiskOngoing patent litigation introduces material structural uncertainty: adverse rulings or delays could enable generic entry, injunctions, or costly settlements that materially reduce YUTREPIA revenue and impair long-term cash generation. Legal outcomes are binary and timing-uncertain, posing sustained downside risk to the commercial franchise.
Balance Sheet LeverageAlthough leverage has improved, absolute debt remains sizable relative to equity, which constrains strategic optionality. Meaningful debt increases interest obligations and can limit ability to pursue large investments or acquisitions; in a downturn, leverage can force tougher financing decisions or slow program timelines.
Commercial Execution RiskThe company's growth roadmap relies on continued prescriber uptake, successful transitions from competitors, and expansion into underdiagnosed PH-ILD markets. Market education needs and patient convenience (dosing frequency) are structural adoption headwinds; failure to sustain momentum would slow revenue scaling and pressure margins and cash generation.