Data Interpretability RiskAnalyst cautions that Phase I results in neovascular AMD can be hard to interpret due to the heterogeneous nature of the disease, limiting confidence in how results will generalize to broader patient groups.
Early-stage Validation UncertaintyAnalyst emphasizes that the early-stage status of the data means efficacy and safety profiles remain provisional until confirmed by larger, randomized trials.
Small Sample Size LimitationsAnalyst warns that small patient numbers in early trials reduce statistical reliability of observed effects, increasing the chance that initial signals may not hold in larger studies.