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Renascience Inc. (JP:4889)
:4889
Japanese Market

Renascience Inc. (4889) AI Stock Analysis

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JP:4889

Renascience Inc.

(4889)

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Neutral 46 (OpenAI - 5.2)
Rating:46Neutral
Price Target:
¥1,442.00
▲(0.42% Upside)
The score is held back primarily by persistent cash burn despite newly positive net income, plus a clearly bearish technical setup (below key moving averages with negative MACD). A strong, debt-free balance sheet is a meaningful offset, but valuation is unfavorable due to the extremely high P/E and no dividend yield data.
Positive Factors
Debt-Free Balance Sheet
A debt-free balance sheet enhances financial stability and flexibility, allowing the company to invest in growth opportunities without the burden of interest payments.
Strong Gross Margin
A strong gross margin indicates effective cost management and pricing power, which can support profitability as the company scales.
Positive Net Income
Turning net income positive is a crucial step towards sustainable profitability, reflecting improved operational efficiency and financial health.
Negative Factors
Negative Cash Flow
Consistently negative cash flow indicates ongoing cash burn, which can strain resources and limit the company's ability to fund operations and growth internally.
Declining Revenue
A decline in revenue suggests challenges in market demand or competitive positioning, which could hinder long-term growth prospects if not addressed.
Negative EBIT
Negative EBIT indicates that the core operations are not yet profitable, which could impact the company's ability to sustain profitability without further improvements.

Renascience Inc. (4889) vs. iShares MSCI Japan ETF (EWJ)

Renascience Inc. Business Overview & Revenue Model

Company DescriptionRenascience Inc. engages in the development and commercialization of pharmaceuticals and medical devices in Japan. The company is developing RS5614, a PAI-1 inhibitor product candidate for use in the treatment of chronic myeloid leukemia, malignant melanoma, non-small cell lung cancer, novel coronavirus infections, and FGF23-related hypophosphatemic rickets that is in Phase 3 clinical trials; RS5441, a PAI-1 inhibitor for use in dermatological diseases that is in Phase I clinical trials; and RS8001, a water-soluble vitamin for use in the treatment of premenstrual syndrome/premenstrual dysphoric mood disorder, autism spectrum disorder, and menopausal disorder, which is in Phase 2 clinical trials. It is also developing RS9001, a disposable ultrafine endoscope; artificial intelligence based medical solutions; and diagnostic solutions. The company was incorporated in 2000 and is headquartered in Tokyo, Japan.
How the Company Makes MoneyRenascience Inc. generates revenue primarily through the sale of its proprietary regenerative medicine products and technologies. The company's key revenue streams include direct sales to healthcare providers, licensing agreements with pharmaceutical companies, and strategic partnerships with research institutions. Additionally, Renascience Inc. may receive funding from government grants and private investors to support its research and development activities. The company leverages its advanced scientific capabilities and expertise to maintain a competitive edge in the biotechnology sector, driving sustainable growth and profitability.

Renascience Inc. Financial Statement Overview

Summary
Renascience Inc. demonstrates financial stability through a strong equity base and low leverage, mitigating risk. However, the company faces challenges in achieving profitability and generating positive cash flows, raising concerns about its operational efficiency and long-term sustainability. Strategic improvements in revenue growth and cost management are essential for enhancing financial performance.
Income Statement
Renascience Inc. shows a significant negative EBIT and EBITDA, indicating high operational losses over the recent periods. Despite a net income improvement in the TTM period, the company's revenue growth has been inconsistent, with fluctuations over the past few years. The gross profit margin remains strong, suggesting effective cost management in production but failing to translate into overall profitability.
Balance Sheet
The company maintains a robust equity position with a high equity ratio, indicating financial stability and low leverage, as evidenced by zero total debt in the TTM period. This suggests a conservative financial structure, minimizing risk exposure. However, the return on equity is poor due to consistent net losses, which impacts investor returns negatively.
Cash Flow
Renascience Inc. exhibits weak cash flow performance, with negative operating and free cash flows in multiple periods, reflecting challenges in generating cash from operations. The lack of recent capital expenditures may suggest underinvestment, potentially affecting future growth. The cash flow to net income ratios are not assessable due to zero or negative values, highlighting liquidity concerns.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue102.69M132.69M194.16M100.55M139.33M209.80M
Gross Profit98.37M128.95M165.64M100.30M77.60M179.82M
EBITDA94.34M143.82M-250.50M-332.49M-244.65M-89.39M
Net Income62.45M113.43M-258.33M-335.80M-254.29M-100.05M
Balance Sheet
Total Assets1.73B1.87B2.09B2.27B2.44B1.07B
Cash, Cash Equivalents and Short-Term Investments1.67B1.80B2.03B2.21B2.39B1.03B
Total Debt0.000.00356.10M309.60M199.23M475.65M
Total Liabilities79.72M151.21M482.11M409.76M237.17M505.10M
Stockholders Equity1.65B1.72B1.61B1.87B2.20B561.53M
Cash Flow
Free Cash Flow0.00-177.14M-232.10M-286.87M-231.66M-90.27M
Operating Cash Flow0.00-176.34M-230.52M-284.64M-230.49M-89.25M
Investing Cash Flow0.00382.15M-1.57M232.00K-296.00K-1.72M
Financing Cash Flow0.00-52.18M46.50M110.37M1.59B135.65M

Renascience Inc. Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1436.00
Price Trends
50DMA
1751.90
Negative
100DMA
1886.46
Negative
200DMA
1857.61
Negative
Market Momentum
MACD
-86.11
Negative
RSI
44.28
Neutral
STOCH
89.37
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4889, the sentiment is Negative. The current price of 1436 is below the 20-day moving average (MA) of 1553.55, below the 50-day MA of 1751.90, and below the 200-day MA of 1857.61, indicating a bearish trend. The MACD of -86.11 indicates Negative momentum. The RSI at 44.28 is Neutral, neither overbought nor oversold. The STOCH value of 89.37 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JP:4889.

Renascience Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
56
Neutral
¥8.54B42.692.99%-52.75%
54
Neutral
¥22.01B-54.84-5.65%-469.19%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
¥14.12B-50.651.24%-33.41%
47
Neutral
¥10.06B-9.53-42.49%-2.37%
46
Neutral
¥20.27B561.01-32.68%
43
Neutral
¥17.49B-9.1411.34%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JP:4889
Renascience Inc.
1,530.00
988.00
182.29%
JP:4599
StemRIM Inc.
279.00
-28.00
-9.12%
JP:4978
ReproCELL Inc.
149.00
44.00
41.90%
JP:7096
StemCell Institute
833.00
-502.00
-37.60%
JP:7774
Japan Tissue Engineering Co., Ltd.
542.00
64.00
13.39%
JP:7776
CellSeed Inc.
283.00
-96.00
-25.33%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025