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AnGes Inc (JP:4563)
:4563
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AnGes (4563) AI Stock Analysis

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JP:4563

AnGes

(4563)

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Underperform 39 (OpenAI - 4o)
Rating:39Underperform
Price Target:
¥68.00
▲(3.03% Upside)
AnGes' overall stock score is primarily impacted by its poor financial performance and valuation. The company's significant losses and negative cash flow are major concerns. Technical analysis indicates a bearish trend, further weighing on the stock's outlook. The lack of earnings call data and corporate events means these factors do not influence the score.
Positive Factors
Revenue Growth
AnGes' significant revenue growth indicates strong demand for its biotechnology products, enhancing its market position and potential for future profitability.
Low Leverage
A low debt-to-equity ratio suggests that AnGes has limited leverage, providing financial stability and flexibility to invest in growth opportunities.
Strategic Partnerships
Collaborations with larger pharmaceutical firms enhance AnGes' distribution reach and research capabilities, supporting long-term growth and innovation.
Negative Factors
Negative Profitability
Persistent negative profitability indicates structural challenges in AnGes' operations, potentially hindering sustainable growth and financial health.
Cash Flow Constraints
Ongoing negative cash flow highlights cash management issues, increasing reliance on external funding and impacting long-term financial stability.
Declining Equity
A decline in stockholders' equity reflects financial strain and may limit AnGes' ability to fund future growth or absorb financial shocks.

AnGes (4563) vs. iShares MSCI Japan ETF (EWJ)

AnGes Business Overview & Revenue Model

Company DescriptionAnGes, Inc., a biopharmaceutical company, engages in the research and development of gene-based medical products. Its lead product is Hepatocyte Growth Factor (HGF) Plasmid, a gene therapy for the treatment of critical limb ischemia, a serious impairment of blood circulation in the leg. The company is also developing NF-kB Decoy Oligonucleotide, a nucleic acid medicine that suppresses inflammation for diseases, including low back pain; drugs for treating atopic dermatitis and disc degeneration; medical devices for the prevention of vascular restenosis; cervical intraepithelial neoplasia therapeutic vaccines for cervical cancer; and DNA vaccines for high blood pressure through collaborative research agreement with Osaka University. AnGes, Inc. has alliances with BioMarin Pharmaceutical Inc. to market Naglazyme, a drug for the treatment of mucopolysaccharidosis VI in Japan; and Mitsubishi Tanabe Pharma Corporation for marketing HGF Plasmid for the treatment of peripheral arterial disease in the United States and Japan. It also has alliances with SHIONOGI & CO., LTD. for the marketing of drugs for external use containing NF-kB decoy oligonucleotide for skin diseases; Vical, Inc. for the development and marketing of Allovectin for cancer treatment; and Osaka University to develop a coronavirus vaccine. In addition, the company has a collaboration agreement with Brickell Biotech, Inc. to develop investigational plasmid DNA vaccine intended to prevent coronavirus in the United States, South America, and other markets. The company was formerly known as AnGes MG, Inc. and changed its name to AnGes, Inc. in July 2017. AnGes, Inc. was founded in 1999 and is headquartered in Ibaraki, Japan.
How the Company Makes MoneyAnGes generates revenue primarily through the development and commercialization of its biotechnology products, which includes licensing agreements, product sales, and research collaborations. The company often partners with larger pharmaceutical companies to leverage their distribution networks and research capabilities, which can lead to milestone payments and royalties. Additionally, AnGes may receive funding through government grants and research subsidies aimed at supporting its innovative therapeutic developments. The combination of these revenue streams allows AnGes to sustain its operations and invest in further research and product development.

AnGes Financial Statement Overview

Summary
AnGes faces significant financial hurdles, with deeply negative EBIT and Net Income margins, persistent negative free cash flow, and reliance on external funding. Despite a low debt-to-equity ratio, the company's inability to generate positive cash flow and profitability raises concerns about its operational efficiency and strategic direction.
Income Statement
25
Negative
AnGes has faced significant challenges in maintaining profitability. The company's EBIT and Net Income margins are deeply negative, indicating considerable losses. While revenue has grown from previous periods, the growth is overshadowed by substantial operating losses. This points to potential structural or strategic challenges in its operations.
Balance Sheet
40
Negative
The balance sheet reflects a moderate financial structure with some areas of concern. The debt-to-equity ratio is low, which is a positive sign of limited leverage. However, the consistent decline in stockholders' equity over recent years and negative net income impact return on equity. Despite a negative net debt position, indicating more cash than debt, persistent losses raise concerns about long-term sustainability.
Cash Flow
30
Negative
Cash flow analysis reveals ongoing cash constraints, with persistent negative free cash flow. The operating cash flow is also negative, further emphasizing cash management challenges. The company has relied on financing activities to support cash flow needs, indicating a dependency on external funding.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue710.98M643.00M152.99M67.06M64.15M40.00M
Gross Profit260.04M247.00M19.45M-26.83M7.43M16.98M
EBITDA-6.25B-5.74B-8.86B-13.41B-13.21B-4.19B
Net Income-28.59B-28.13B-7.44B-14.71B-13.68B-4.21B
Balance Sheet
Total Assets5.79B4.67B28.89B38.82B45.46B38.35B
Cash, Cash Equivalents and Short-Term Investments2.91B1.71B4.16B11.04B17.90B11.54B
Total Debt198.79M272.45M362.68M1.16B0.000.00
Total Liabilities2.38B2.51B2.79B8.40B6.82B5.67B
Stockholders Equity3.40B2.16B26.10B30.43B38.63B32.68B
Cash Flow
Free Cash Flow0.00-6.69B-8.84B-11.23B-11.46B-3.04B
Operating Cash Flow0.00-6.61B-8.74B-11.21B-11.38B-2.96B
Investing Cash Flow0.00-130.80M-356.65M-97.14M-154.87M-6.96B
Financing Cash Flow0.004.20B2.04B3.57B17.38B11.40B

AnGes Technical Analysis

Technical Analysis Sentiment
Negative
Last Price66.00
Price Trends
50DMA
79.64
Negative
100DMA
80.04
Negative
200DMA
72.82
Negative
Market Momentum
MACD
-4.00
Positive
RSI
32.43
Neutral
STOCH
10.00
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4563, the sentiment is Negative. The current price of 66 is below the 20-day moving average (MA) of 72.85, below the 50-day MA of 79.64, and below the 200-day MA of 72.82, indicating a bearish trend. The MACD of -4.00 indicates Positive momentum. The RSI at 32.43 is Neutral, neither overbought nor oversold. The STOCH value of 10.00 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JP:4563.

AnGes Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
58
Neutral
¥19.66B-5.65%-469.19%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
¥16.96B-8.775.58%
43
Neutral
¥15.15B-14.61-42.49%-2.37%
39
Underperform
$27.80B-184.71%56.75%-97.56%
39
Underperform
¥54.84B-82.33%47.73%
32
Underperform
¥16.18B14.03%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JP:4563
AnGes
66.00
14.00
26.92%
JP:4575
CanBas Co., Ltd.
790.00
-57.00
-6.73%
JP:4593
Healios KK
425.00
242.00
132.24%
JP:4599
StemRIM Inc.
254.00
-94.00
-27.01%
JP:7774
Japan Tissue Engineering Co., Ltd.
502.00
20.00
4.15%
JP:7776
CellSeed Inc.
270.00
-200.00
-42.55%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 26, 2025