Company-wide Operational Sales Growth and Revenue
Q1 2026 worldwide sales of $24.1 billion with operational sales growth of 6.4% (reported midpoint guidance implies $100.8B for 2026). Excluding STELARA headwind (~540 bps), the company grew in double digits in the quarter. U.S. growth was 8.3% and ex-U.S. growth was 3.9%.
Raised Full-Year Guidance
Increased 2026 operational sales guidance to a range of 5.9%–6.9% (midpoint $100.2B, 6.4%) and reported sales growth estimate 6.5%–7.5% (midpoint $100.8B, 7%). Adjusted operational EPS guidance raised $0.02 to $11.30–$11.50 (midpoint +5.7%); reported adjusted EPS midpoint $11.55 (+7.1%).
Innovative Medicine Strong Growth and New Launch Momentum
Innovative Medicine sales $15.4 billion, up 7.4% operationally despite ~920 bps STELARA headwind. Ten brands delivered double-digit growth; 28 platforms or products each generate at least $1B in annual revenue. Notable new launches and approvals (ICOTYDE, TECVAYLI+DARZALEX FASPRO approval, RYBREVANT FASPRO subcutaneous approval).
High-Growth Product Performance (Oncology & Immunology)
DARZALEX sales ~$4.0B, up ~18% (17.8% reported); CARVYKTI ~ $600M, +57.4%; TECVAYLI +30.1% (sequential +14.2%); TALVEY +72.8%; RYBREVANT+LAZCLUZE $257M, +80.5% (sequential +18.8%); ERLEADA +16.2%. TREMFYA up ~63.8% and projected to exceed $10B peak sales.
Breakthrough Launch of ICOTYDE
ICOTYDE approved for first-line plaque psoriasis (oral IL‑23 peptide). Day-one launch with first patient on therapy within 24 hours; ~1,500 prescriptions and >1,000 unique prescribers in early launch period. Management calls it a potential multi‑billion dollar asset and a market-expanding systemic-first choice.
MedTech Growth and New Product Innovation
MedTech sales $8.6 billion, +4.6% operationally. Strong segments: electrophysiology +9.5% (new VARIPULSE launches), Abiomed +14.4% (Impella adoption), Shockwave +18.1% (IVL adoption). Multiple device approvals/data (VARIPULSE Pro EU launch, OMNYPULSE 12‑month positive data, TECNIS PureSee FDA approval).
INLEXZO Early Commercial Traction and Reimbursement Milestone
INLEXZO sales slightly above $30M in Q1; received permanent J‑code reimbursement April 1. Management reports ~1 in 5 eligible patients started INLEXZO in Q1; following J‑code, new patient insertions increased ~50% in week 1 and ~90% in week 2.
Cash Position, Capital Allocation and Dividend Increase
Cash & marketable securities ~$22B, debt $55B (net debt ~$33B). Q1 free cash flow ~$1.5B with full‑year free cash flow outlook ~ $21B. Board authorized a 3.1% dividend increase to $5.36/year (64th consecutive year of dividend growth).
Investments in U.S. Manufacturing & R&D
Company progressing on $55B U.S. investment plan (manufacturing, tech, R&D) with ~$12B invested through end-2025 (~22% of target) and continued significant investments in 2026.
Pipeline Visibility and Near-Term Catalysts
Multiple upcoming catalysts in 2026 across oncology, immunology and neuroscience (e.g., TREMFYA approval for psoriatic arthritis, ERLEADA data, INLEXZO expansion, JNJ‑4804 IBD data, CAPLYTA bipolar mania data) and several MedTech submissions/approvals (OTTAVA, VARIPULSE Pro U.S., Dual Energy THERMOCOOL in U.S.).