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Jaguar Animal Health
(NASDAQ:JAGX)
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Rating:40Underperform
Price Target:
$0.98
▲(1.98% Upside)
Action:Downgraded
Date:07/24/26
The score is driven primarily by very weak financial performance (large ongoing losses, negative equity, and renewed cash burn). Technicals reinforce the risk profile with a pronounced downtrend and negative momentum. Corporate events provide some operational and strategic positives (supply continuity, strategic alternatives, Nasdaq bid compliance) but are counterbalanced by dilution/financing actions and recent listing-compliance pressure, while valuation offers limited support due to losses and no dividend.
Positive Factors
Manufacturing supply secured
A multi-year crofelemer supply agreement through March 31, 2029 secures manufacturing continuity for Mytesi and pipeline crofelemer products. Guaranteed supply and defined volumes reduce operational execution risk, enabling predictable production planning and supporting commercialization of rare-disease indications over several years.
Negative Factors
Negative equity and leverage
Persistently negative shareholders' equity and modest total assets versus obligations constrain financial flexibility. Negative equity complicates access to traditional financing, increases creditor and covenant risk, and leaves limited balance-sheet cushion to absorb further operating shortfalls or fund late-stage development.
Read all positive and negative factors
Positive Factors
Negative Factors
Manufacturing supply secured
A multi-year crofelemer supply agreement through March 31, 2029 secures manufacturing continuity for Mytesi and pipeline crofelemer products. Guaranteed supply and defined volumes reduce operational execution risk, enabling predictable production planning and supporting commercialization of rare-disease indications over several years.
Read all positive factors
Jaguar Animal Health (JAGX) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$4.91M
Dividend YieldN/A
Average Volume (3M)94.49K
Price to Earnings (P/E)―
Beta (1Y)2.42
Revenue Growth155.96%
EPS Growth87.56%
CountryUS
Employees47
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-708.72
Shares Outstanding4,910,402
10 Day Avg. Volume116,531
30 Day Avg. Volume94,486
Financial Highlights & Ratios
PEG Ratio<0.01
Price to Book (P/B)-0.13
Price to Sales (P/S)0.19
P/FCF Ratio0.38
Enterprise Value/Market Cap<0.01
Enterprise Value/Revenue<0.01
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price TargetN/A
Price Target UpsideN/A
Rating ConsensusN/A
Number of Analyst Covering0
EPS Forecast (FY)-4.2
Revenue Forecast (FY)$2.46M
Jaguar Animal Health Business Overview & Revenue Model
Company Description
Jaguar Health, Inc., a commercial-stage pharmaceutical firm, specializes in developing prescription therapies for both human and animal patients afflicted by gastrointestinal ailments, particularly chronic and severe diarrhea. Its operations are s...
How the Company Makes Money
Jaguar Animal Health primarily makes money through (1) product sales and (2) licensing/partnering related income when applicable.
1) Product sales (core revenue stream)
- Animal health product revenue: The company sells gastrointestinal products ...
Jaguar Animal Health Earnings Call Summary
Earnings Call Date:Apr 07, 2026
(Q4-2025)
| % Change Since: |
Next Earnings Date:Aug 19, 2026
Earnings Call Sentiment Neutral
The call presented meaningful strategic and clinical positives — a sizable non-dilutive upfront/licensing arrangement, manufacturing revenue upside, and compelling proof-of-concept data with 12%–37% reductions in parenteral support and a targeted NDA timeline (H1 2027) for MVID. However, these positives are balanced by near-term commercial and financial challenges: YoY revenue decline, sustained and growing operating losses (net loss to $53.6M; Non-GAAP recurring EBITDA loss $48.1M), declining Mytesi prescription volumes, and increased dependency on partner milestone payments and manufacturing revenue under the out-license. Overall, the call communicated promising development and BD catalysts that could be transformative long term but also highlighted significant short-term financial pressures and commercialization trade-offs.Positive Updates
Non-Dilutive Licensing Deal with Future Pak
Closed U.S. out-license for Mytesi and Canalevia-CA1 with $18M upfront (company reported $16M received at signing, $2M conditional), additional ~$20M in potential milestone and future payments, and roughly $3M–$4M of additional payments already received. Jaguar will continue to manufacture crofelemer and recognize manufacturing revenue; the deal provides immediate non-dilutive cash to fund rare-disease development.
Negative Updates
Declining Mytesi Prescription Volume
Mytesi prescription volume declined ~3.7% in 2025 vs 2024, declined ~5.8% in Q4 2025 vs Q3 2025, and declined ~12.2% in Q4 2025 vs Q4 2024. Company notes specialty pharmacy inventory dynamics contribute to variability between prescription and invoiced sales volume.
Read all updates
Q4-2025 Updates
Positive
Negative
Non-Dilutive Licensing Deal with Future Pak
Closed U.S. out-license for Mytesi and Canalevia-CA1 with $18M upfront (company reported $16M received at signing, $2M conditional), additional ~$20M in potential milestone and future payments, and roughly $3M–$4M of additional payments already received. Jaguar will continue to manufacture crofelemer and recognize manufacturing revenue; the deal provides immediate non-dilutive cash to fund rare-disease development.
Read all positive updates
Company Guidance
The company’s guidance centers on “continued business development” in 2026 with near-term clinical, regulatory and BD catalysts over the next 6–12 months and a clear goal to license its crofelemer rare-disease program: target filing of an NDA for MVID in first half of 2027 (MVID global prevalence ≈200 patients) following completion of a fully enrolled placebo‑controlled trial (with ongoing treatment‑only extension), pursuit of FDA Breakthrough designation and EMA PRIME, and parallel Phase II randomized double‑blind placebo‑controlled development in short bowel syndrome‑IF (SBS‑IF; U.S. patient estimate ≈12,000) where third‑party market estimates put opportunity at ~$8 billion; proof‑of‑concept investigator data in three pediatric IF patients showed parenteral‑support reductions of 12%–37% (12.5%–15.6% in two SBS patients, ~37% in one MVID), with even 5% reductions described as meaningful; financial guidance emphasizes non‑dilutive funding (Future Pak licensing: $18M upfront with $16M received to date, $2M conditional, ~$20M in potential milestones and >$3M additional payments reported, Future Pak also paid $3M tied to termination of a buy‑back provision), Jaguar to remain manufacturer and recognize manufacturing revenue, Q4 2025 net revenue ≈$3.2M (+5% vs Q3 2025 $3.1M; −8% vs Q4 2024 $3.5M), 2025 total net revenue ≈$11.5M (≈$11.2M from Mytesi and Canalevia‑CA1), Mytesi prescription volume down ~3.7% in 2025 vs 2024 (Q4 2025 vs Q3 2025 down ~5.8%; Q4 2025 vs Q4 2024 down ~12.2%), loss from operations increased $15.1M to $45.9M in 2025, Non‑GAAP Recurring EBITDA net loss $48.1M (2025) vs $35.9M (2024), net loss attributable to common shareholders $53.6M (2025) vs $38.5M (2024), and the company expects these clinical, regulatory and BD milestones to drive partnership discussions and additional non‑dilutive funding.Jaguar Animal Health Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
12
Very Negative
Cash Flow
20
Very Negative
| Breakdown | Mar 2026 | Mar 2025 | Mar 2024 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 11.51M | 11.69M | 9.76M | 11.96M | 4.33M |
| Gross Profit | 7.74M | 9.73M | 7.72M | 9.94M | 2.00M |
| EBITDA | -51.73M | -36.66M | -32.76M | -33.38M | -42.37M |
| Net Income | -53.43M | -38.49M | -41.30M | -47.45M | -52.59M |
Balance Sheet | |||||
| Total Assets | 38.32M | 53.42M | 50.76M | 47.45M | 53.27M |
| Cash, Cash Equivalents and Short-Term Investments | 968.00K | 8.00M | 6.47M | 5.47M | 17.05M |
| Total Debt | 43.61M | 36.53M | 37.09M | 34.84M | 29.36M |
| Total Liabilities | 57.01M | 46.93M | 45.87M | 48.81M | 41.41M |
| Stockholders Equity | -17.29M | 7.29M | 4.96M | -657.00K | 11.61M |
Cash Flow | |||||
| Free Cash Flow | 5.77M | -29.61M | -33.24M | -34.78M | -34.98M |
| Operating Cash Flow | 5.80M | -29.38M | -33.24M | -33.10M | -34.97M |
| Investing Cash Flow | 149.00K | -231.00K | 0.00 | -1.68M | -6.00K |
| Financing Cash Flow | -44.33M | 31.20M | 34.23M | 23.18M | 43.94M |
Jaguar Animal Health Technical Analysis
Negative
0.96
Price Trends
2.25
Negative
6.30
Negative
22.92
Negative
Market Momentum
-0.46
Negative
26.68
Positive
41.74
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JAGX, the sentiment is Negative. The current price of 0.96 is below the 20-day moving average (MA) of 1.38, below the 50-day MA of 2.25, and below the 200-day MA of 22.92, indicating a bearish trend. The MACD of -0.46 indicates Negative momentum. The RSI at 26.68 is Positive, neither overbought nor oversold. The STOCH value of 41.74 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JAGX.
Jaguar Animal Health Risk Analysis
Jaguar Animal Health disclosed 71 risk factors in its most recent earnings report. Jaguar Animal Health reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Jaguar Animal Health Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
48 Neutral | $4.90M | -0.36 | 937.72% | ― | -72.74% | 48.64% | |
43 Neutral | $7.60M | -0.04 | -164.92% | ― | -9.46% | 18.03% | |
40 Underperform | $4.91M | >-0.01 | 764.53% | ― | 155.96% | 87.56% | |
39 Underperform | $5.02M | -0.05 | -709.51% | ― | -100.00% | 77.63% |
* Healthcare Sector Average
JAGX
Jaguar Animal Health
0.94
-72.56
-98.72%
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Evogene
0.69
-0.54
-44.31%
GOVX
GeoVax Labs
0.72
-16.01
-95.69%
CODX
Co-Diagnostics
1.42
-5.98
-80.81%
Jaguar Animal Health Corporate Events
Business Operations and Strategy
Jaguar Animal Health Signs New Crofelemer Supply Agreement
Positive
Jul 15, 2026
On July 9, 2026, Napo Pharmaceuticals entered a new manufacturing and supply agreement with Alivus Life Sciences to continue producing crofelemer for Mytesi® and other crofelemer‑based products. The deal replaces a prior agreement that ...
Business Operations and StrategyDividendsStock Split
Jaguar Health Completes Conversion of Series O Preferred
Positive
Jul 1, 2026
On March 4, 2026, Jaguar Health paid a special one-time dividend of Series O Convertible Preferred Stock tied to its outstanding voting common shares and certain dividend-rights warrants, based on a March 2, 2026 record date and retroactively adju...
Business Operations and StrategyDividends
Jaguar Animal Health Converts Series O Preferred to Common
Positive
Jun 25, 2026
On June 22, 2026, Jaguar subsidiary Napo Pharmaceuticals amended its manufacturing and supply agreement with Puerto Rico-based Woodward Specialty to clarify inventory ownership, transfer locations, and management responsibilities during an operati...
Business Operations and Strategy
Jaguar Health Begins Strategic Alternatives Review for Crofelemer
Positive
Jun 22, 2026
On June 22, 2026, Jaguar Health announced that its board has launched a review of strategic alternatives aimed at maximizing shareholder value, timed to coincide with the anticipated completion of clinical work supporting a planned New Drug Applic...
Business Operations and StrategyPrivate Placements and Financing
Jaguar Health Restructures Royalty Deals and Extends Debt
Negative
Jun 19, 2026
On June 17, 2026, Jaguar Health amended a $12 million royalty interest with Uptown Capital to require, starting October 1, 2026, a minimum monthly royalty payment of $750,000 or the actual royalty amount due, whichever is higher. The company the s...
Business Operations and StrategyPrivate Placements and Financing
Jaguar Animal Health Secures New Equity and Preferred Funding
Neutral
Jun 11, 2026
On June 9, 2026, Jaguar Health entered a common stock purchase agreement with an accredited institutional investor, establishing an equity line of credit of up to $40 million, with purchases governed by fixed and VWAP-based mechanisms and subject ...
Executive/Board ChangesPrivate Placements and FinancingShareholder Meetings
Jaguar Health Shareholders Approve Financing and Governance Proposals
Positive
Jun 8, 2026
On June 8, 2026, Jaguar Health reconvened its 2026 annual stockholders’ meeting, originally held May 22 and subsequently adjourned, and reported that shareholders approved all five proposals on the ballot. Investors backed the election of Jo...
Private Placements and FinancingRegulatory Filings and ComplianceShareholder Meetings
Jaguar Animal Health Postpones 2026 Stockholder Meeting Again
Neutral
Jun 2, 2026
On May 19, 2026, Jaguar Health, Inc. issued 408 shares of Series Q Perpetual Preferred Stock to Streeterville Capital, LLC, and subsequently, on May 26 and June 1, 2026, the company entered into two privately negotiated exchange agreements with St...
Business Operations and StrategyDelistings and Listing ChangesFinancial DisclosuresRegulatory Filings and Compliance
Jaguar Health Regains Nasdaq Bid Price Compliance Status
Positive
May 27, 2026
On May 27, 2026, Jaguar Health announced it had received formal notice on May 26, 2026, from Nasdaq that the company had regained compliance with the exchange’s minimum bid price requirement, allowing its shares to continue trading on the ma...
Private Placements and FinancingRegulatory Filings and ComplianceShareholder Meetings
Jaguar Animal Health Adjourns 2026 Annual Shareholder Meeting
Neutral
May 22, 2026
On May 21, 2026, Jaguar Health, Inc. entered into privately negotiated exchange agreements with Streeterville Capital, LLC under which it issued 54,222 shares of common stock in exchange for 7.96 shares of its Series Q Perpetual Preferred Stock, w...
Business Operations and StrategyPrivate Placements and Financing
Jaguar Animal Health Issues Series Q Preferred Stock
Neutral
May 19, 2026
On May 19, 2026, Jaguar Health entered into privately negotiated exchange agreements with Uptown Capital and Streeterville Capital, issuing a total of 908 shares of new Series Q Perpetual Preferred Stock in exchange for a combined $22.7 million re...
Delistings and Listing ChangesRegulatory Filings and Compliance
Jaguar Animal Health Granted Short Nasdaq Compliance Extension
Negative
May 7, 2026
On May 6, 2026, Jaguar Health received a decision from a Nasdaq Hearings Panel granting a short extension to regain compliance with Nasdaq’s listing rules, following a May 1, 2026 notice that it had fallen below the required 500,000 publicly...
Delistings and Listing ChangesRegulatory Filings and ComplianceStock Split
Jaguar Health Boosts Public Float to Regain Nasdaq Compliance
Positive
May 4, 2026
On May 1, 2026, Jaguar Health disclosed that a 1-for-35 reverse stock split, effective April 30, 2026, had reduced its publicly held common shares to about 401,226, putting the company below Nasdaq’s 500,000-share minimum and leaving it non-...
Delistings and Listing ChangesRegulatory Filings and ComplianceStock Split
Jaguar Animal Health Faces New Nasdaq Compliance Deficiency
Negative
May 4, 2026
On May 1, 2026, Jaguar Health reported that Nasdaq staff notified the company it was out of compliance with the exchange’s minimum 500,000 publicly held shares requirement following a 1-for-35 reverse stock split effected on April 30, 2026, ...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.