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Jaguar Animal Health (JAGX)
NASDAQ:JAGX

Jaguar Animal Health (JAGX) AI Stock Analysis

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Jaguar Animal Health

(NASDAQ:JAGX)

Rating:40Underperform
Price Target:
$3.00
▼(-7.41%Downside)
Jaguar Animal Health's overall stock score reflects significant financial challenges and bearish technical indicators, which weigh heavily on the score. While there are promising developments in product trials and strategic corporate actions, these are overshadowed by the company's high leverage, ongoing net losses, and negative cash flow trends.

Jaguar Animal Health (JAGX) vs. SPDR S&P 500 ETF (SPY)

Jaguar Animal Health Business Overview & Revenue Model

Company DescriptionJaguar Animal Health, operating under the ticker symbol JAGX, is a commercial-stage pharmaceuticals company that focuses on developing and commercializing gastrointestinal products for animals and humans. Operating primarily in the animal health and human health sectors, Jaguar is committed to identifying and advancing innovative, plant-based treatments derived from rainforest botanical extracts. The company's core product is Canalevia-CA1, a prescription drug designed to treat chemotherapy-induced diarrhea in dogs, reflecting Jaguar's commitment to addressing unmet medical needs in veterinary health.
How the Company Makes MoneyJaguar Animal Health generates revenue through the sale of its proprietary pharmaceutical products and royalties from licensing agreements. The company's primary revenue stream comes from the commercialization of Canalevia-CA1, which is sold to veterinary clinics and specialists to treat gastrointestinal conditions in dogs. In addition to direct sales, Jaguar benefits from strategic partnerships and collaborations that expand its research and distribution capabilities, including licensing agreements with pharmaceutical companies that enable it to earn royalties on products developed using its technology. These partnerships also contribute to the company's earnings by providing additional avenues for product development and market penetration.

Jaguar Animal Health Earnings Call Summary

Earnings Call Date:May 15, 2025
(Q1-2025)
|
% Change Since: -47.49%|
Next Earnings Date:Aug 13, 2025
Earnings Call Sentiment Neutral
The earnings call presented a mix of positive breakthroughs in medical research with crofelemer and ongoing financial challenges. While there were significant advancements in clinical trials and potential regulatory approvals, the financial metrics showed a decline in revenue and increased losses.
Q1-2025 Updates
Positive Updates
Increased Prescriptions for Mytesi
Dispensed prescriptions for Mytesi increased by approximately 2% in Q1 2025 compared to Q1 2024, indicating increased demand and treatment for HIV-related diarrhea.
Groundbreaking Results for Crofelemer
Initial proof-of-concept results showed that crofelemer reduced TPN by up to 27% in the first MVID patient and by up to 12.5% in the first pediatric SBS patient, which is significant for patients with intestinal failure.
Significant Results in Breast Cancer Patients
In the OnTarget study, crofelemer achieved statistically significant results in breast cancer patients, and these findings are being presented at notable conferences.
Exploration of Regulatory Pathways for Expedited Approval
Jaguar is exploring expedited regulatory approval pathways for crofelemer in treating MVID and short bowel syndrome, with orphan designation potentially allowing for faster approvals.
Negative Updates
Decrease in Total Net Revenue
Total net revenue for the company's products decreased by approximately 6% in Q1 2025 compared to Q1 2024 and by 37% compared to Q4 2024.
Loss from Operations
Loss from operations increased by $1.2 million from $8.2 million in Q1 2024 to $9.4 million in Q1 2025.
Net Loss for Shareholders
Net loss attributable to common shareholders increased by approximately $1.2 million from $9.2 million in Q1 2024 to $10.4 million in Q1 2025.
Company Guidance
During the May 15, 2025, investor webcast, Jaguar Health's CEO, Lisa Conte, discussed several key metrics and initiatives. Notably, dispensed prescriptions for Mytesi, a treatment for HIV-related diarrhea, increased by approximately 2% in Q1 2025 compared to Q1 2024, despite a decrease in net revenue. Initial proof-of-concept results for crofelemer showed a reduction in total parenteral nutrition (TPN) by up to 27% in the first MVID patient, highlighting its potential impact on rare diseases. Jaguar's rare disease programs, in development for nearly eight years, include ongoing trials for MVID and short bowel syndrome, with results expected through 2025 and 2026. Financially, the company reported a 6% decrease in net revenue for Q1 2025 versus Q1 2024, while non-GAAP recurring EBITDA reflected a net loss of $9.7 million. Additionally, Jaguar is exploring expedited regulatory pathways and potential business development opportunities to enhance stakeholder value.

Jaguar Animal Health Financial Statement Overview

Summary
Jaguar Animal Health demonstrates substantial financial challenges with high leverage, consistent net losses, and negative cash flows. Despite some revenue growth and strong gross margins, operational inefficiencies and debt management remain critical areas for improvement.
Income Statement
35
Negative
Jaguar Animal Health has shown a mixed performance with inconsistent revenue growth. The revenue grew by approximately 18.38% from 2023 to 2024 but showed a decline previously. Gross profit margins are reasonably high, but the company struggles with negative EBIT and net income margins, indicating ongoing operational and profitability challenges.
Balance Sheet
30
Negative
The company's balance sheet indicates high leverage with a Debt-to-Equity ratio of approximately 5.63 in 2024, reflecting significant reliance on debt financing. The return on equity is negative due to consistent net losses, and the equity ratio is low, suggesting financial instability and potential risks related to excessive debt.
Cash Flow
40
Negative
Cash flow analysis reveals a negative trend in free and operating cash flows, although there was a slight improvement from 2023 to 2024. The company managed to secure significant financing cash flows, which have been covering operational deficits. However, the negative free cash flow to net income ratio highlights ongoing cash management issues.
Breakdown
TTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
11.51M11.69M9.76M11.96M4.33M9.38M
Gross Profit
9.47M9.73M7.72M9.94M2.00M6.11M
EBIT
-32.04M-30.83M-34.29M-34.41M-39.07M-21.30M
EBITDA
-38.48M-36.66M-33.13M-33.38M-42.35M-28.74M
Net Income Common Stockholders
-39.73M-38.49M-41.30M-47.45M-60.25M-36.79M
Balance SheetCash, Cash Equivalents and Short-Term Investments
5.69M8.00M6.47M5.47M17.05M8.09M
Total Assets
51.46M53.42M50.76M47.45M53.27M42.84M
Total Debt
38.34M36.53M37.09M34.84M29.36M16.21M
Net Debt
32.65M28.52M30.63M29.37M12.31M8.12M
Total Liabilities
48.15M46.93M45.87M48.81M41.41M25.64M
Stockholders Equity
830.00K7.29M4.96M-657.00K11.61M17.20M
Cash FlowFree Cash Flow
-29.87M-29.61M-33.24M-34.78M-34.98M-15.29M
Operating Cash Flow
-29.65M-29.38M-33.24M-33.10M-34.97M-15.28M
Investing Cash Flow
-231.00K-231.00K1.23M-1.68M-6.00K-7.00K
Financing Cash Flow
23.90M31.20M34.23M23.18M43.94M19.49M

Jaguar Animal Health Technical Analysis

Technical Analysis Sentiment
Negative
Last Price3.24
Price Trends
50DMA
6.30
Negative
100DMA
10.57
Negative
200DMA
18.69
Negative
Market Momentum
MACD
-0.94
Negative
RSI
28.15
Positive
STOCH
7.47
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JAGX, the sentiment is Negative. The current price of 3.24 is below the 20-day moving average (MA) of 4.14, below the 50-day MA of 6.30, and below the 200-day MA of 18.69, indicating a bearish trend. The MACD of -0.94 indicates Negative momentum. The RSI at 28.15 is Positive, neither overbought nor oversold. The STOCH value of 7.47 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JAGX.

Jaguar Animal Health Risk Analysis

Jaguar Animal Health disclosed 65 risk factors in its most recent earnings report. Jaguar Animal Health reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Jaguar Animal Health Peers Comparison

Overall Rating
UnderperformOutperform
Sector (54)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$4.17M-163.47%-100.00%78.91%
54
Neutral
$5.34B3.36-45.10%3.39%16.81%-0.03%
40
Underperform
$4.36M-423.79%13.93%91.30%
34
Underperform
$3.88M-105.70%-100.00%28.48%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JAGX
Jaguar Animal Health
3.24
-94.51
-96.69%
TTNP
Titan Pharmaceuticals
4.40
-2.58
-36.96%
HSCS
Heart Test Laboratories, Inc.
3.72
-1.39
-27.20%

Jaguar Animal Health Corporate Events

Private Placements and FinancingBusiness Operations and Strategy
Jaguar Health Announces $1.5M Direct Stock Offering
Positive
May 22, 2025

On May 20, 2025, Jaguar Health, Inc. entered into a securities purchase agreement for a registered direct offering of 246,306 shares of common stock at $6.09 per share, expected to raise approximately $1.5 million. The offering, set to close around May 22, 2025, includes a concurrent private placement of unregistered warrants to purchase up to 492,612 shares. The proceeds will be used for corporate purposes, including working capital and debt repayment. H.C. Wainwright & Co. acted as the placement agent, receiving a fee and warrants as compensation. This move is part of Jaguar’s strategy to strengthen its financial position and support its operational and development goals.

Private Placements and FinancingBusiness Operations and StrategyFinancial Disclosures
Jaguar Animal Health Executes Stock Exchange Agreements
Neutral
May 15, 2025

On May 13 and 14, 2025, Jaguar Health, Inc. executed several stock exchange agreements to manage its financial obligations. The company issued common and preferred stock to reduce outstanding royalty interests and replace existing preferred stock, impacting its financial structure and shareholder equity. These transactions are part of Jaguar’s broader strategy to optimize its capital structure and potentially improve its market positioning. Additionally, Jaguar reported a decrease in first-quarter 2025 revenue compared to the previous year and quarter, with a notable increase in sales and marketing expenses due to expanded market access activities.

Product-Related AnnouncementsBusiness Operations and Strategy
Jaguar Health Highlights Promising Crofelemer Study Results
Positive
May 9, 2025

On May 9, 2025, Jaguar Health released a slide presentation detailing its ongoing efforts to develop and commercialize crofelemer for various indications, including HIV-related diarrhea and short bowel syndrome. Recent studies presented in April 2025 showed promising results for crofelemer in reducing parenteral support in patients with intestinal failure, potentially improving their quality of life. The company is also pursuing additional business development deals and regulatory designations to enhance its market positioning.

Product-Related AnnouncementsBusiness Operations and Strategy
Jaguar Health Announces Promising Crofelemer Trial Results
Positive
Apr 30, 2025

On April 30, 2025, Jaguar Health announced promising initial results from a proof-of-concept trial of crofelemer, a novel liquid formulation aimed at reducing the need for total parenteral nutrition (TPN) in patients with microvillus inclusion disease (MVID) and short bowel syndrome with intestinal failure (SBS-IF). The trial demonstrated that crofelemer reduced TPN requirements by up to 27% and 12.5% for MVID and SBS-IF patients, respectively, and showed potential for improving nutrient absorption and quality of life. These findings may support crofelemer’s inclusion in expedited regulatory programs in the EU and US, highlighting its potential as a novel therapeutic option for these rare conditions.

Product-Related AnnouncementsBusiness Operations and Strategy
Jaguar Health Schedules Webcast on Crofelemer Trial Results
Positive
Apr 28, 2025

On April 28, 2025, Jaguar Health announced an investor webcast scheduled for April 30, 2025, to discuss preliminary results from a proof-of-concept trial of crofelemer for treating rare diseases like microvillus inclusion disease and short bowel syndrome with intestinal failure. The webcast will cover patient experiences, the drug’s impact on disease progression, and potential regulatory pathways, highlighting Jaguar’s commitment to addressing unmet clinical needs and its strategic positioning in the pharmaceutical industry.

Product-Related AnnouncementsBusiness Operations and Strategy
Jaguar Health Presents at Elite Ped-GI Congress 2025
Positive
Apr 25, 2025

Jaguar Health announced its participation in the 11th Annual Elite Ped-GI Congress 2025 in Abu Dhabi, where they will present proof-of-concept data for their products, including crofelemer. The company is actively pursuing business development opportunities and regulatory designations in the U.S. and Europe, aiming to expand the market reach of crofelemer for various indications, which could significantly impact their market positioning and stakeholder interests.

Private Placements and Financing
Jaguar Animal Health Secures $3.448M in Private Placement
Positive
Apr 4, 2025

On March 31, 2025, Jaguar Health closed a private placement, raising approximately $3.448 million through convertible promissory notes and warrants. The funds will be used for working capital and general corporate purposes, with expectations of key catalysts in the second quarter of 2025 related to crofelemer development for rare diseases and cancer therapy-related diarrhea, potentially enhancing the company’s value.

Delistings and Listing ChangesStock Split
Jaguar Animal Health Announces Reverse Stock Split
Neutral
Mar 18, 2025

Jaguar Health, Inc. announced a reverse stock split of its common stock at a 1-for-25 ratio, effective March 24, 2025, to comply with Nasdaq listing standards and attract institutional investors. The reverse stock split will reduce the number of shares and increase the share price, with no fractional shares issued; stockholders will receive cash for any fractional shares. The company’s stock will continue trading on Nasdaq under the symbol ‘JAGX’ with a new CUSIP number.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.