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Iteos Therapeutics, Inc. (ITOS)
:ITOS
US Market
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iTeos Therapeutics (ITOS) AI Stock Analysis

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ITOS

iTeos Therapeutics

(NASDAQ:ITOS)

Rating:49Neutral
Price Target:
$10.00
▼(-0.99% Downside)
iTeos Therapeutics' overall stock score is driven by serious financial and valuation concerns, despite a favorable technical position and potential benefits from corporate events. The merger announcement offers some optimism, but strategic challenges and negative financials weigh heavily.
Positive Factors
Acquisition
The acquisition by Concentra Biosciences is likely to close with the top two shareholders, EcoR1 and Tang Capital, in a positive position.
Cash Position
ITeos ended 1Q:25 with cash of $624 million, indicating a strong cash position before the acquisition.
Strategic Review
Investors reacted positively to the news of belrestotug’s termination, with the stock showing an increase, likely due to the announcement of a strategic review to maximize shareholder value.
Negative Factors
Legal Risks
The deal lacks a provision for shareholder vote, which may lead to legal disputes similar to other Concentra deals.
Pipeline Development
There is low confidence that any early-stage immuno-oncology asset will add value for iTeos in the next year, as the investor bar for excitement is high.
Shareholder Expectations
The terms of the acquisition may not meet broader shareholder expectations, being approximately 30% to previously disclosed iTeos cash.

iTeos Therapeutics (ITOS) vs. SPDR S&P 500 ETF (SPY)

iTeos Therapeutics Business Overview & Revenue Model

Company DescriptionIteos Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of immuno-oncology therapeutics for patients. The company's product pipeline includes inupadenant, a small molecule antagonist of the adenosine A2AR antagonists that is in Phase 2 clinical trials; and EOS-448, an antagonist of TIGIT or T-cell immunoreceptor with Ig and ITIM domains, which is in Phase 1/2 clinical trial, as well as used to engage the Fc gamma receptor, or Fc?R to activate dendritic cells and macrophages and to promote antibody-dependent cellular cytotoxicity, or ADCC activity. Iteos Therapeutics, Inc. was founded in 2011 and is headquartered in Watertown, Massachusetts.
How the Company Makes MoneyiTeos Therapeutics makes money through the development and commercialization of its proprietary drug candidates. The company's revenue model is primarily based on partnerships, collaborations, and licensing agreements with larger pharmaceutical companies. These partnerships often involve upfront payments, milestone payments, and royalties on sales of successfully developed therapies. Additionally, iTeos may receive revenue from grants and research funding. Key revenue streams include strategic alliances with industry leaders, which enable the company to leverage external resources and expertise to advance its drug candidates through the clinical trial phases and towards regulatory approval.

iTeos Therapeutics Financial Statement Overview

Summary
iTeos Therapeutics faces significant financial challenges with declining profitability, negative cash flows, and reliance on external financing. Despite a strong equity base, the overall financial health is concerning and needs improvement in revenue generation and cost management.
Income Statement
28
Negative
iTeos Therapeutics has experienced significant volatility in its revenue and profitability. The TTM (Trailing-Twelve-Months) data shows a severe decline in profitability, with negative EBIT and net income margins. Revenue growth is stagnant, as current revenue matches the previous period. These trends reflect challenges in generating consistent revenue and managing costs, which is critical for long-term sustainability.
Balance Sheet
52
Neutral
The balance sheet reveals a strong equity base, with a high equity ratio indicating stability. However, the debt-to-equity ratio is low, which is positive, though offset by declining total assets and stockholders' equity over recent periods. Despite these strengths, the decrease in cash reserves and equity suggests potential challenges in maintaining financial health if current trends continue.
Cash Flow
40
Negative
The cash flow situation is concerning with negative operating and free cash flows, indicating struggles in generating cash from operations. The free cash flow growth rate is negative, highlighting a worsening trend. Despite a positive financing cash flow, reliance on external funding is not a sustainable strategy for cash flow management.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue35.00M12.60M267.63M344.77M0.00
Gross Profit33.76M11.70M266.82M344.16M-535.00K
EBITDA-159.53M-151.10M148.38M257.08M-37.84M
Net Income-134.41M-112.64M96.65M214.52M-38.03M
Balance Sheet
Total Assets686.98M667.59M754.99M884.71M344.56M
Cash, Cash Equivalents and Short-Term Investments494.65M531.92M613.16M848.54M336.33M
Total Debt5.10M6.06M4.67M5.34M0.00
Total Liabilities96.68M92.36M91.66M331.89M21.36M
Stockholders Equity590.29M575.23M663.33M552.82M323.20M
Cash Flow
Free Cash Flow-99.81M-106.72M-112.13M511.96M-25.53M
Operating Cash Flow-98.18M-103.76M-111.19M513.14M-25.18M
Investing Cash Flow-131.15M72.66M-446.06M-1.24M-377.00K
Financing Cash Flow122.24M1.11M1.98M3.66M340.34M

iTeos Therapeutics Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price10.10
Price Trends
50DMA
10.02
Positive
100DMA
8.40
Positive
200DMA
8.19
Positive
Market Momentum
MACD
0.06
Positive
RSI
53.08
Neutral
STOCH
8.55
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ITOS, the sentiment is Neutral. The current price of 10.1 is below the 20-day moving average (MA) of 10.18, above the 50-day MA of 10.02, and above the 200-day MA of 8.19, indicating a neutral trend. The MACD of 0.06 indicates Positive momentum. The RSI at 53.08 is Neutral, neither overbought nor oversold. The STOCH value of 8.55 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for ITOS.

iTeos Therapeutics Risk Analysis

iTeos Therapeutics disclosed 63 risk factors in its most recent earnings report. iTeos Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

iTeos Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (60)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$405.17M-41.31%-7.93%
60
Neutral
HK$17.57B4.99-4.95%3.61%9.71%-38.85%
49
Neutral
$386.95M-34.97%14.60%
49
Neutral
$425.48M-48.98%-9.95%20.78%
48
Neutral
$569.36M34.94%
38
Underperform
$399.42M-48.22%
35
Underperform
$490.97M-783.37%81.94%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ITOS
iTeos Therapeutics
10.11
-4.87
-32.51%
GOSS
Gossamer Bio
2.16
1.34
163.41%
CMPX
Compass Therapeutics
2.78
1.77
175.25%
ABSI
AbSci
2.95
-0.82
-21.75%
BCAX
Bicara Therapeutics Inc.
11.36
-14.05
-55.29%
MBX
MBX Biosciences, Inc.
11.95
-9.70
-44.80%

iTeos Therapeutics Corporate Events

M&A TransactionsBusiness Operations and Strategy
iTeos Therapeutics Announces Merger with Concentra Biosciences
Positive
Jul 21, 2025

On July 18, 2025, iTeos Therapeutics entered into a merger agreement with Concentra Biosciences, where Concentra will acquire iTeos for $10.047 in cash per share plus a contingent value right. The iTeos board has unanimously approved the merger, which is expected to close in the third quarter of 2025, subject to certain conditions including a minimum cash requirement and shareholder approval. This acquisition is seen as beneficial for iTeos’ stockholders and aligns with the company’s strategic goals.

The most recent analyst rating on (ITOS) stock is a Hold with a $12.00 price target. To see the full list of analyst forecasts on iTeos Therapeutics stock, see the ITOS Stock Forecast page.

Executive/Board ChangesShareholder Meetings
iTeos Therapeutics Holds Annual Stockholders Meeting
Neutral
Jun 17, 2025

iTeos Therapeutics, Inc. held its Annual Meeting of Stockholders on June 17, 2025, with a quorum of 87.67% of outstanding shares present or represented by proxy. During the meeting, stockholders elected Tony Ho, Robert Iannone, and Ann D. Rhoades as Class II directors for a three-year term and ratified Deloitte Bedrijfsrevisoren / Réviseurs d’Entreprises BV/SRL as the independent registered public accounting firm for the fiscal year ending December 31, 2025.

The most recent analyst rating on (ITOS) stock is a Hold with a $12.00 price target. To see the full list of analyst forecasts on iTeos Therapeutics stock, see the ITOS Stock Forecast page.

Executive/Board Changes
Tim Van Hauwermeiren Resigns from iTeos Board
Neutral
Jun 5, 2025

On June 1, 2025, Tim Van Hauwermeiren resigned from the Board of Directors of iTeos Therapeutics, Inc., effective immediately. His resignation was not due to any disagreements with the company, its management, or the board, indicating a smooth transition without internal conflict.

The most recent analyst rating on (ITOS) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on iTeos Therapeutics stock, see the ITOS Stock Forecast page.

Business Operations and Strategy
iTeos Therapeutics Announces Strategic Wind Down Plan
Negative
May 28, 2025

On May 28, 2025, iTeos Therapeutics announced its plan to wind down its clinical and operational activities as part of a strategic review to maximize shareholder value. This decision follows the termination of its belrestotug development program and collaboration with GlaxoSmithKline, leading to expected charges related to severance, contract terminations, and winding down costs. The company will focus on leveraging its cash balance and exploring potential asset sales, including EOS-984, EOS-215, and a preclinical obesity program targeting ENT1, to deliver near-term value to shareholders.

The most recent analyst rating on (ITOS) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on iTeos Therapeutics stock, see the ITOS Stock Forecast page.

Business Operations and Strategy
iTeos Therapeutics Ends Collaboration with GSK
Negative
May 13, 2025

On May 13, 2025, iTeos Therapeutics and GlaxoSmithKline (GSK) announced the termination of their collaboration and license agreement, originally established in June 2021, following interim results from the GALAXIES Lung-201 study. The study, which assessed the combination of belrestotug and dostarlimab in non-small cell lung cancer, did not meet the criteria for progression-free survival improvements, leading to the decision to end the belrestotug development program. This termination will result in the cessation of financial obligations between the two companies and the end of new enrollment in ongoing trials. iTeos plans to explore strategic alternatives to maximize shareholder value, despite the disappointing trial results.

The most recent analyst rating on (ITOS) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on iTeos Therapeutics stock, see the ITOS Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 22, 2025