Total Net Sales and Monthly Recovery
Q1 net product sales of $34.7 million with March recovering to over $15 million, signaling a strong sequential rebound after early-quarter disruption.
Acute Care Revenue Growth
Acute Care combined net sales of $13.6 million (ZYNRELEF $10.2M, APONVIE $3.4M) with ZYNRELEF demand unit growth of 22% year-over-year and APONVIE demand units up 68% year-over-year (average daily units +70% YoY).
ZYNRELEF Adoption and IGNITE Program Success
IGNITE 1.0 drove unit volume in targeted accounts from ~9,000 to >19,000 units (111% growth) in two quarters. IGNITE 2.0 expands targeted accounts 38% (from 2,261 to 3,109 accounts), supporting continued ZYNRELEF adoption and sequential share gains in a softer local anesthetic market.
APONVIE Clinical Endorsement and Access Expansion
APONVIE achieved P&T approval in 1,903 accounts representing 5.8 million medium-to-high-risk procedures annually, permanent product-specific J-code effective April 1, and prominent inclusion in the fifth consensus PONV guidelines (A1 evidence rating), positioning it as the evidence-graded standard for PONV prophylaxis.
Oncology Franchise Durability (CINVANTI)
CINVANTI delivered stable performance with Q1 net sales of $20.5 million and an exit NK1 market share of 25% (12-month average 25%). The REIGNITE program is expected to add ~ $10 million in near-term annualized net revenue from new formulary wins.
Pricing Discipline and Strategic Positioning
Company maintained pricing discipline across active products: ZYNRELEF net selling price trending upward, APONVIE price stable during growth phase, and CINVANTI temporary Q4 dip reverted in Q1. Management emphasized protecting long-term economics rather than chasing volume via concessions.
Commercial and R&D Investments on Track
Sales force expansions for ZYNRELEF and a dedicated aprepitant team are on track for Q3 2026. ZYNRELEF prefilled syringe (PFS) program fully funded and on schedule with registration batches manufactured and 12-month stability data planned for Q1 2027.
Full-Year Guidance Maintained
Management reaffirmed 2026 guidance: net product sales $173 million to $183 million and adjusted EBITDA $10 million to $20 million, citing Q1 weather-related softness as temporary and visible recovery underway.