JW (Cayman) Therapeutics Co. Ltd. (2126) AI Stock Analysis

• Market Cap: HK$1.01B
• Dividend Yield: N/A
• Average Volume (3M): 2.67M
• Price to Earnings (P/E): ―
• Beta (1Y): 1.71
• Revenue Growth: 2.45%
• EPS Growth: 2.58%
• Country: HK
• Employees: 281
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.72
• Shares Outstanding: 416,473,240
• 10 Day Avg. Volume: 1,852,649
• 30 Day Avg. Volume: 2,667,300
• PEG Ratio: 0.04
• Price to Book (P/B): 0.43
• Price to Sales (P/S): 3.14
• P/FCF Ratio: -1.43
• Enterprise Value/Market Cap: N/A
• Enterprise Value/Revenue: N/A
• Enterprise Value/Gross Profit: N/A
• Enterprise Value/Ebitda: N/A
• 1Y Price Target: N/A
• Price Target Upside: N/A
• Rating Consensus: N/A
• Number of Analyst Covering: 0
• EPS Forecast (FY): N/A
• Revenue Forecast (FY): N/A

• Rating: 41 Neutral
• Price Target: HK$2.50 ▲(0.00% Upside)

The overall stock score is primarily impacted by the company's financial performance, which shows strong revenue growth but significant profitability challenges. Technical analysis indicates bearish momentum, while valuation metrics are unfavorable due to negative earnings and lack of dividends.

Positive Factors

Consistent revenue growth

Sustained revenue growth indicates expanding commercial traction and market adoption of therapies, improving prospects for scale. Over 2-6 months this supports ongoing R&D funding, partnership leverage, and likelihood of moving programs toward commercialization despite current losses.

Strong cash position and low leverage

A strong cash balance and conservative leverage provide financial flexibility to fund clinical programs and manufacturing investments without immediate refinancing. This durability reduces short-term solvency risk and supports multi-quarter execution of development milestones.

Favorable structural market for cell therapies

Structural tailwinds for CAR-T and cell therapies expand the addressable market and long-term pricing and reimbursement potential. This secular demand supports sustained commercial opportunity for approved products and underpins strategic partnerships and licensing interest.

Negative Factors

Persistent unprofitability

Ongoing net losses signal the business is not yet generating sustainable profits, limiting free cash available for reinvestment. Over several quarters this increases dependence on external capital, can pressure strategic choices, and delays value creation for shareholders.

Negative operating and free cash flow

Consistent negative operating and free cash flow indicate the company cannot self-fund operations or capex. This structural cash shortfall necessitates recurring financing, raising dilution and refinancing risk and constraining investment in commercial scale-up or manufacturing capacity.

Negative return on equity

A negative ROE shows deployed capital has yet to produce shareholder returns, undermining long-term investor confidence. Persistently negative ROE can hinder access to favorable financing and make it harder to attract strategic partners seeking financially accretive collaborators.

JW (Cayman) Therapeutics Co. Ltd. Business Overview & Revenue Model

Company Description

JW (Cayman) Therapeutics Co. Ltd, a clinical stage cell therapy company, focuses on developing, manufacturing, and commercializing cell-based immunotherapies for hematological cancers and solid tumors. The company offers cell-based immunotherapies, including CAR-T treatments, which is a treatment method that uses human immune cells to fight cancer. Its lead product candidate is Carteyva (relmacabtagene autoleucel), an anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy for the treatment of a range of hematological cancers. The company's pipeline products include JWCAR129, an autologous CAR-T therapy for the treatment of multiple myeloma; JWATM204, a TCR T-cell therapy candidate for the treatment of HCC; and JWATM203, an autologous T-cell receptor mimic T-cell therapy targeting alpha-fetoprotein for the treatment of hepatocellular carcinoma. JW (Cayman) Therapeutics Co. Ltd was founded in 2016 and is headquartered in Shanghai, the People's Republic of China.

How the Company Makes Money

JW (Cayman) Therapeutics generates revenue through several key streams. Primarily, the company earns money from the commercialization of its proprietary cell therapy products once they receive regulatory approval and are launched in the market. Additionally, JW Therapeutics may engage in strategic partnerships and collaborations with other pharmaceutical companies, which can provide upfront payments, milestone payments, and royalties based on product sales. The company might also benefit from government grants and funding aimed at supporting innovative therapeutic development. Furthermore, the increasing demand for advanced cancer treatments and the growing prevalence of cancer worldwide contribute significantly to its revenue potential.

JW (Cayman) Therapeutics Co. Ltd. Financial Statement Overview

Summary

The company shows strong revenue growth but struggles with profitability, as indicated by negative net income and EBIT margins. The balance sheet is stable with a strong cash position, but negative operating cash flow and free cash flow highlight operational inefficiencies.

Income Statement

The company has shown consistent revenue growth over the years, with a notable increase from 2020 onwards. However, profitability remains a significant issue as the company has reported negative net income and EBIT margins throughout the years, indicating ongoing operational challenges. The gross profit margin has improved slightly, yet the high net losses overshadow these gains.

Balance Sheet

The company's balance sheet is relatively stable with a strong cash position, as indicated by the significant cash and cash equivalents. The debt-to-equity ratio remains low, suggesting conservative leverage. However, the continued net losses have adversely affected the return on equity, which remains negative. The equity ratio indicates a solid equity base compared to total assets, pointing to financial stability despite ongoing losses.

Cash Flow

Operating cash flow has been consistently negative, reflecting challenges in generating cash from operations. The company has managed to maintain a positive cash position largely through financing activities. Free cash flow remains negative, indicating that the company is not yet self-sustaining and relies on external funding to cover operational and capital expenditures.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	177.75M	158.22M	173.86M	145.70M	30.80M	0.00
Gross Profit	98.69M	77.32M	88.22M	58.76M	9.04M	0.00
EBITDA	-256.23M	-381.58M	-655.75M	-752.27M	-738.70M	-454.04M
Net Income	-617.62M	-590.62M	-768.00M	-846.13M	-702.33M	-1.66B
Balance Sheet
Total Assets	1.42B	1.68B	2.15B	2.79B	3.12B	3.78B
Cash, Cash Equivalents and Short-Term Investments	647.04M	762.53M	1.01B	1.39B	1.84B	2.63B
Total Debt	372.46M	422.40M	318.80M	279.13M	147.03M	123.59M
Total Liabilities	510.83M	511.20M	462.26M	437.06M	325.75M	349.76M
Stockholders Equity	908.61M	1.17B	1.68B	2.35B	2.79B	3.43B
Cash Flow
Free Cash Flow	-202.73M	-348.87M	-413.00M	-613.60M	-634.28M	-385.24M
Operating Cash Flow	-200.13M	-333.44M	-398.42M	-536.72M	-561.20M	-261.00M
Investing Cash Flow	-2.84M	-15.43M	9.90M	-124.08M	-137.13M	-91.91M
Financing Cash Flow	-20.67M	90.49M	275.00K	112.35M	-30.62M	2.86B

JW (Cayman) Therapeutics Co. Ltd. Technical Analysis

• Technical Analysis Sentiment: Negative
• Last Price: 2.50
• 50DMA: Negative
• 100DMA: Negative
• 200DMA: Negative
• MACD: Positive
• RSI: Neutral
• STOCH: Positive

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HK:2126, the sentiment is Negative. The current price of 2.5 is below the 20-day moving average (MA) of 2.71, below the 50-day MA of 2.85, and below the 200-day MA of 3.33, indicating a bearish trend. The MACD of -0.10 indicates Positive momentum. The RSI at 35.53 is Neutral, neither overbought nor oversold. The STOCH value of 14.48 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for HK:2126.

JW (Cayman) Therapeutics Co. Ltd. Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
9966	53 Neutral	HK$8.68B	33.97	13.34%	―	206.58%	―
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
2179	44 Neutral	HK$2.40B	-3.40	-129.05%	―	―	-18.99%
2616	42 Neutral	HK$7.80B	-17.23	-95.84%	―	-55.64%	-158.67%
2126	41 Neutral	HK$1.01B	-1.48	-51.56%	―	2.45%	2.58%
2157	40 Underperform	HK$8.66B	-41.39	-21.42%	―	240.05%	-140.09%

JW (Cayman) Therapeutics Co. Ltd. Corporate Events

JW Therapeutics Grants New Share Options and RSUs to CEO and Key Staff

JW (Cayman) Therapeutics has granted a total of 2.6 million share options and 650,000 restricted share units to four grantees under its post-IPO equity incentive and restricted share unit schemes adopted in 2020, as part of its ongoing remuneration and retention strategy. The bulk of the options, 1.5 million, were awarded to CEO and executive director Feng Tian at an exercise price of HK$2.92 per share, with options and RSUs subject to multi-year vesting schedules; the company’s remuneration committee stated that the time-based vesting for Tian, without additional performance targets, is consistent with its customary equity-based pay practices and aimed at aligning management interests with shareholders over the long term.

The most recent analyst rating on (HK:2126) stock is a Hold with a HK$3.00 price target. To see the full list of analyst forecasts on JW (Cayman) Therapeutics Co. Ltd. stock, see the HK:2126 Stock Forecast page.

JW Therapeutics Outlines Board and Committee Structure

JW (Cayman) Therapeutics Co. Ltd has announced the current composition of its board of directors, which includes one executive director, four non-executive directors and three independent non-executive directors, with Cheng Liu serving as chairman. The company has also detailed the membership and leadership of its four key board committees—audit, remuneration, nomination, and business development and strategy—clarifying governance responsibilities and oversight structures, which underscores its ongoing efforts to strengthen corporate governance and strategic decision-making for stakeholders.

The most recent analyst rating on (HK:2126) stock is a Hold with a HK$3.00 price target. To see the full list of analyst forecasts on JW (Cayman) Therapeutics Co. Ltd. stock, see the HK:2126 Stock Forecast page.

JW Therapeutics Extends Vector Supply Agreement With Juno to 2028

JW (Cayman) Therapeutics has extended the term of its vector supply agreement with substantial shareholder Juno through 31 December 2028, ensuring continued access to critical vectors used in the commercialization and further clinical development of its CAR-T therapy Carteyva®. The transaction is classified as a continuing connected transaction under Hong Kong Listing Rules, subject only to reporting and announcement requirements since the applicable percentage ratios for the extended period from 2026 to 2028 remain below 5%, meaning it is exempt from circular and independent shareholder approval, and historical payments under the agreement have stayed within previously approved annual caps.

The most recent analyst rating on (HK:2126) stock is a Hold with a HK$3.00 price target. To see the full list of analyst forecasts on JW (Cayman) Therapeutics Co. Ltd. stock, see the HK:2126 Stock Forecast page.

JW Therapeutics Announces Key Leadership Changes

JW (Cayman) Therapeutics Co. Ltd. has announced significant leadership changes, including the appointment of Mr. Tian Feng as the new Chief Executive Officer and Executive Director, effective December 29, 2025. Mr. Tian brings over 20 years of experience in the biopharmaceutical industry, with a strong background in commercialization and strategic management. These changes are expected to enhance the company’s strategic direction and operational efficiency, potentially impacting its market positioning and stakeholder interests positively.

The most recent analyst rating on (HK:2126) stock is a Hold with a HK$3.00 price target. To see the full list of analyst forecasts on JW (Cayman) Therapeutics Co. Ltd. stock, see the HK:2126 Stock Forecast page.

JW Therapeutics Announces Board Composition and Roles

JW (Cayman) Therapeutics Co. Ltd. has announced the composition of its board of directors, highlighting the roles and functions of each member. The board comprises non-executive and independent non-executive directors, with specific members serving on various committees, such as the Audit, Remuneration, Nomination, and Business Development and Strategy Committees. This announcement is significant as it outlines the governance structure and strategic oversight within the company, potentially impacting its operational and strategic direction.

The most recent analyst rating on (HK:2126) stock is a Hold with a HK$3.00 price target. To see the full list of analyst forecasts on JW (Cayman) Therapeutics Co. Ltd. stock, see the HK:2126 Stock Forecast page.

JW Therapeutics Reports Promising Results for JWCAR201 in Hematology Study

JW Therapeutics presented promising data from its JWCAR201 study at the American Society of Hematology Annual Meeting. The study, which involved patients with relapsed/refractory diffuse large B-cell lymphoma, showed a 100% overall response rate and an 85.7% complete response rate, with manageable safety profiles. These results highlight the potential for JWCAR201 to advance to the Investigational New Drug stage, offering hope for patients with limited treatment options.

The most recent analyst rating on (HK:2126) stock is a Hold with a HK$3.00 price target. To see the full list of analyst forecasts on JW (Cayman) Therapeutics Co. Ltd. stock, see the HK:2126 Stock Forecast page.