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Gyre Therapeutics (GYRE)
NASDAQ:GYRE

Gyre Therapeutics (GYRE) AI Stock Analysis

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Gyre Therapeutics

(NASDAQ:GYRE)

Rating:52Neutral
Price Target:
$11.50
▲( 32.49% Upside)
The overall stock score for Gyre Therapeutics is driven primarily by recent positive corporate events, which highlight significant strategic progress and potential market impact. However, this is offset by financial performance challenges, particularly in cash flow and valuation concerns due to a high P/E ratio. Technical analysis suggests some positive momentum, but these factors are secondary to the strategic developments.

Gyre Therapeutics (GYRE) vs. SPDR S&P 500 ETF (SPY)

Gyre Therapeutics Business Overview & Revenue Model

Company DescriptionGyre Therapeutics, Inc., a pharmaceutical company, engages in the development and commercialization of small-molecule, anti-inflammatory, and anti-fibrotic drugs targeting organ fibrosis. It offers ETUARY (Pirfenidone), an anti-fibrotic drug approved for the treatment of idiopathic pulmonary fibrosis; and under phase 3 studies for dermatomyositis and systemic sclerosis-associated interstitial lung disease, pneumoconiosis, and diabetic kidney disease. The company is also involved the development of F351 (Hydronidone), a structural derivative of ETUARY (Pirfenidone), under Phase 3 studies for the treatment of chronic hepatitis B liver fibrosis; and under Phase 1 studies for liver fibrosis associated with nonalcoholic associated steatohepatitis. In addition, its development pipeline includes F573, under Phase 2 studies for the treatment of acute/acute-on-chronic liver failure; F528, under preclinical stage for the treatment of chronic obstructive pulmonary disease; and F230, under preclinical stage for the treatment of pulmonary arterial hypertension. The company was founded in 2002 and is headquartered in San Diego, California. Gyre Therapeutics, Inc. operates as a subsidiary of GNI USA, Inc.
How the Company Makes Moneynull

Gyre Therapeutics Financial Statement Overview

Summary
Gyre Therapeutics shows mixed financial performance. While operational efficiencies have improved as reflected in better EBIT and EBITDA margins, revenue growth is volatile. The balance sheet is strengthening with a solid equity base, but past volatility in equity levels poses a risk. Liquidity challenges are evident with negative free cash flow and inconsistent operating cash flow.
Income Statement
45
Neutral
Gyre Therapeutics has shown inconsistent revenue growth, with a significant drop from 2023 to 2024. The gross profit margin remains high, indicating efficient production costs, but the net profit margin is volatile due to fluctuating net income. The EBIT and EBITDA margins have improved over the years, reflecting some stabilization in operational efficiency.
Balance Sheet
50
Neutral
The company's balance sheet shows a strong equity base as of 2024, with a favorable debt-to-equity ratio indicating low leverage. However, the past volatility in stockholders' equity, including negative equity in 2023, could pose a risk. The equity ratio is strong, showing a good proportion of assets financed by equity.
Cash Flow
40
Negative
Cash flow from operations has been inconsistent, with a significant negative figure in 2024. Free cash flow has also been negative, raising concerns about liquidity. The operating cash flow to net income ratio is concerning due to negative operating cash flow, indicating potential cash management issues.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
105.76M113.45M794.00K7.34M20.95M
Gross Profit
101.87M108.81M-4.00K-42.00K11.79M
EBIT
16.16M-67.23M-8.61M-87.89M-57.37M
EBITDA
17.82M20.33M10.33M-87.60M-57.37M
Net Income Common Stockholders
12.09M-92.93M2.30M-87.93M-55.54M
Balance SheetCash, Cash Equivalents and Short-Term Investments
26.67M33.51M21.67M46.85M79.35M
Total Assets
125.41M116.54M28.44M55.66M94.85M
Total Debt
1.60M409.00K38.00K2.38M1.64M
Net Debt
-10.21M-33.10M-21.63M-41.96M-28.72M
Total Liabilities
27.00M38.06M50.13M14.57M18.78M
Stockholders Equity
63.32M-15.83M-21.69M41.09M76.07M
Cash FlowFree Cash Flow
-5.96M17.31M-38.09M-84.59M-55.31M
Operating Cash Flow
-3.64M25.89M-33.10M-83.75M-55.05M
Investing Cash Flow
-19.88M-19.76M55.43M48.19M9.66M
Financing Cash Flow
2.10M2.50M-45.01M49.55M60.38M

Gyre Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price8.68
Price Trends
50DMA
9.18
Negative
100DMA
10.25
Negative
200DMA
11.47
Negative
Market Momentum
MACD
0.39
Positive
RSI
43.03
Neutral
STOCH
48.38
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GYRE, the sentiment is Negative. The current price of 8.68 is below the 20-day moving average (MA) of 10.02, below the 50-day MA of 9.18, and below the 200-day MA of 11.47, indicating a bearish trend. The MACD of 0.39 indicates Positive momentum. The RSI at 43.03 is Neutral, neither overbought nor oversold. The STOCH value of 48.38 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for GYRE.

Gyre Therapeutics Risk Analysis

Gyre Therapeutics disclosed 84 risk factors in its most recent earnings report. Gyre Therapeutics reported the most risks in the “Legal & Regulatory” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
If we fail to maintain proper and effective internal controls over financial reporting our ability to produce accurate and timely financial statements could be impaired. Q4, 2024
2.
result in material misstatements of our consolidated financial statements or cause us to fail to meet our periodic reporting obligations. Q4, 2024
3.
The enacted "Holding Foreign Companies Accountable Act" and the "Accelerating Holding Foreign Companies Accountable Act" call for additional and more stringent criteria to be applied to emerging market companies upon assessing the qualification of their auditors, especially the non-U.S. auditors who are not inspected by the Public Company Accounting Oversight Board. These developments could add uncertainties to the market for our common stock. Q4, 2024

Gyre Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (53)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
63
Neutral
$773.55M222.83%29.88%35.11%
54
Neutral
$979.90M-57.92%-13.37%2.57%
53
Neutral
$5.14B3.03-43.89%2.83%16.75%-0.06%
52
Neutral
$987.61M234.0311.62%
47
Neutral
$596.97M-15.59%-35.41%-12.26%
47
Neutral
$741.01M-64.16%-30.25%-5.92%
42
Neutral
$893.14M-51.85%0.71%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GYRE
Gyre Therapeutics
8.68
-3.31
-27.61%
NTLA
Intellia Therapeutics
9.16
-15.68
-63.12%
XERS
Xeris Pharmaceuticals
4.83
2.90
150.26%
NRIX
Nurix Therapeutics
9.72
-5.45
-35.93%
ABCL
AbCellera Biologics
1.97
-1.88
-48.83%
PHVS
Pharvaris
15.99
-4.19
-20.76%

Gyre Therapeutics Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
Gyre Therapeutics Achieves Key Milestone in Phase 3 Trial
Positive
May 22, 2025

On May 22, 2025, Gyre Therapeutics announced that its lead compound, Hydronidone, achieved the primary endpoint in a pivotal Phase 3 trial for treating liver fibrosis in patients with chronic hepatitis B in China. The 52-week trial demonstrated a statistically significant regression in liver fibrosis with Hydronidone compared to placebo, showing favorable safety and tolerability. This milestone positions Hydronidone as a potential first-in-class therapy for CHB-associated liver fibrosis, with plans for regulatory submission in China and further trials in the U.S.

The most recent analyst rating on (GYRE) stock is a Buy with a $20.00 price target. To see the full list of analyst forecasts on Gyre Therapeutics stock, see the GYRE Stock Forecast page.

Product-Related AnnouncementsBusiness Operations and Strategy
Gyre Therapeutics Highlights Fibrosis Treatment Strategy
Positive
Apr 28, 2025

On April 28, 2025, Gyre Therapeutics released an updated corporate presentation highlighting its pioneering efforts in fibrosis treatment. The presentation detailed the company’s robust pipeline, including its lead asset F351, which targets chronic hepatitis B-related liver fibrosis, a significant unmet medical need in China. Gyre’s strategic approach involves a China-first validation strategy to leverage faster patient enrollment and cost efficiency, followed by expansion into the U.S. This strategy aims to mitigate clinical and regulatory risks while maintaining market leadership since the commercialization of pirfenidone in 2014.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.