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FibroGen (FGEN)
NASDAQ:FGEN
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FibroGen (FGEN) AI Stock Analysis

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FibroGen

(NASDAQ:FGEN)

Rating:47Neutral
Price Target:
$8.00
▲(4.58%Upside)
FibroGen's overall score is primarily driven by its financial instability, with declining revenues and ongoing losses. While technical analysis provides some positive signals, valuation concerns and revenue declines weigh heavily on its investment appeal. Strategic moves highlighted in the earnings call offer some optimism but are overshadowed by financial difficulties.
Positive Factors
Financial Performance
The strong cash balance permits both flexibility and boosts confidence that FG-3246's clinical endeavors can progress without interruption for the foreseeable future.
Pipeline Development
FibroGen remains focused on advancing FG-3246, with upcoming studies that provide multiple shots on goal.
Strategic Transactions
The sale of FibroGen China to AstraZeneca is considered a strategic transaction, providing FibroGen with additional capital and streamlining its portfolio.
Negative Factors
Financial Obligations
The cost reduction program has been completed.
Regulatory Uncertainty
Management conveyed that interactions with the FDA have progressed in a timely manner with no delays, despite investor uncertainties.
Settlement Costs
Announced a settlement related to roxadustat, which will result in a $1.25 million civil penalty paid to FibroGen.

FibroGen (FGEN) vs. SPDR S&P 500 ETF (SPY)

FibroGen Business Overview & Revenue Model

Company DescriptionFibroGen, Inc., a biopharmaceutical company, discovers, develops, and commercializes therapeutics to treat serious unmet medical needs. The company is developing Roxadustat, an oral small molecule inhibitor of hypoxia inducible factor prolyl hydroxylases, which has completed Phase III clinical development for the treatment of anemia in chronic kidney disease in the United States, Europe, China, and Japan; and in Phase II/III development in China for anemia associated with myelodysplastic syndromes. It is also developing Pamrevlumab, a human monoclonal antibody that inhibits the activity of connective tissue growth factor that is in Phase III clinical development for the treatment of idiopathic pulmonary fibrosis, pancreatic cancer, liver fibrosis, and diabetic kidney disease, as well as Phase III trial for the treatment of Duchenne muscular dystrophy. The company has collaboration agreements with Astellas Pharma Inc. and AstraZeneca AB. FibroGen, Inc. was incorporated in 1993 and is headquartered in San Francisco, California.
How the Company Makes MoneyFibroGen generates revenue through the development and commercialization of pharmaceutical products, particularly those related to its proprietary HIF and anti-fibrotic technologies. The company earns money through collaboration agreements, licensing deals, and the sale of its approved drugs. Significant revenue streams include milestone payments and royalties from partnerships with major pharmaceutical companies such as AstraZeneca and Astellas Pharma, which help in the global commercialization of its anemia drug, Roxadustat. These collaborations not only provide upfront and milestone payments but also a share of future sales, contributing significantly to FibroGen's earnings.

FibroGen Earnings Call Summary

Earnings Call Date:May 12, 2025
(Q1-2025)
|
% Change Since: 0.13%|
Next Earnings Date:Aug 11, 2025
Earnings Call Sentiment Neutral
The earnings call presented a transformative period for FibroGen, with the sale of FibroGen China to AstraZeneca bringing in higher than expected proceeds and extending their financial runway significantly. There is notable progress in their clinical pipeline, particularly in the development of FG-3246 and FG-3180, with promising results from clinical trials. However, the company faced a significant decline in revenue and continued to operate at a net loss. While the highlights indicate strategic advancements and positive financial prospects, the revenue decline and continued net loss are concerning.
Q1-2025 Updates
Positive Updates
Increased Sale Proceeds from FibroGen China
The sale of FibroGen China to AstraZeneca now expected to bring approximately $185 million, a $25 million increase from initial guidance due to greater than expected net cash in China at closing.
Extension of Cash Runway
The increased proceeds from the FibroGen China sale are expected to extend the company's cash runway into the second half of 2027.
Promising Clinical Developments
Phase 1 monotherapy study of FG-3246 in metastatic castration-resistant prostate cancer (mCRPC) showed a median radiographic progression-free survival of 8.7 months, with an overall response rate of 20%.
Regulatory Milestones Achieved
FDA cleared the IND for FG-3180, a companion PET imaging agent, marking an important achievement for FibroGen.
Cost Reductions
Total operating costs and expenses for the first quarter of 2025 were $17.7 million, a decrease of 76% year-over-year.
Negative Updates
Significant Revenue Decline
Total revenue for the first quarter of 2025 was $2.7 million compared to $25.4 million for the same period in 2024.
Net Loss Continues
The company recorded a net loss from continuing operations of $16.8 million for the first quarter of 2025.
Company Guidance
During the FibroGen First Quarter 2025 Earnings Conference Call, the company provided key financial and strategic guidance. The sale of FibroGen China to AstraZeneca is expected to close in Q3 2025, with total consideration now approximately $185 million, a $25 million increase from initial estimates. This transaction extends FibroGen's cash runway into the second half of 2027. The company remains focused on advancing its U.S. pipeline, particularly FG-3246 and FG-3180 for metastatic castration-resistant prostate cancer (mCRPC). FG-3246 demonstrated a median radiographic progression-free survival (rPFS) of 8.7 months in Phase 1, and FG-3180 received FDA clearance for its IND. FibroGen anticipates important FDA feedback on Roxadustat in anemia associated with lower-risk myelodysplastic syndromes by Q3. Full-year 2025 total revenue is projected between $4 million and $8 million, with operating expenses ranging from $70 million to $80 million, marking a 58% reduction from 2024.

FibroGen Financial Statement Overview

Summary
FibroGen is facing significant financial challenges as evidenced by declining revenues, persistent losses, negative stockholders' equity, and negative cash flow. These indicate operational inefficiencies and financial instability that require urgent attention to restore investor confidence.
Income Statement
45
Neutral
FibroGen has experienced declining revenue over the past few years, with a significant drop in 2024 compared to previous years. This decline is coupled with persistent negative EBIT and net income, indicating operational challenges and profitability issues. The company also shows negative EBITDA, reflective of its struggles to manage costs effectively amidst falling revenues.
Balance Sheet
30
Negative
The balance sheet reveals high liabilities relative to assets, resulting in negative stockholders' equity, a concerning sign of financial instability. The absence of debt in 2024 is positive, but previous years show reliance on debt, contributing to financial stress. The negative equity ratio further highlights the precarious financial position, indicating significant leverage and risk.
Cash Flow
40
Negative
Operating cash flow has been consistently negative, pointing to challenges in generating cash from core operations. Although free cash flow improved slightly in 2024, it remains negative, indicating cash burn. The cash flow to net income ratios highlight inefficient cash management and an inability to convert revenue into cash profits.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue-23.54M29.62M46.80M140.73M235.31M176.32M
Gross Profit-13.60M14.06M42.84M120.45M222.44M167.45M
EBITDA-127.66M-142.43M-305.20M-282.82M-274.80M-164.28M
Net Income-10.01M-47.58M-284.23M-295.23M-291.03M-189.29M
Balance Sheet
Total Assets165.21M214.53M423.53M610.09M773.82M826.84M
Cash, Cash Equivalents and Short-Term Investments33.61M50.48M235.59M422.01M405.19M686.54M
Total Debt0.0073.09M170.46M89.89M99.73M37.72M
Total Liabilities340.14M398.16M585.73M611.57M544.71M385.39M
Stockholders Equity-174.93M-183.63M-204.17M-21.45M209.15M422.18M
Cash Flow
Free Cash Flow-76.25M-138.26M-317.54M-184.67M-112.42M77.61M
Operating Cash Flow-75.99M-138.00M-315.02M-145.93M-82.23M81.60M
Investing Cash Flow74.70M125.99M153.66M89.12M-426.97M452.49M
Financing Cash Flow-178.00K-255.00K122.75M46.78M-563.00K13.34M

FibroGen Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price7.65
Price Trends
50DMA
7.03
Positive
100DMA
7.78
Negative
200DMA
9.31
Negative
Market Momentum
MACD
0.25
Negative
RSI
59.56
Neutral
STOCH
86.01
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FGEN, the sentiment is Neutral. The current price of 7.65 is above the 20-day moving average (MA) of 6.21, above the 50-day MA of 7.03, and below the 200-day MA of 9.31, indicating a neutral trend. The MACD of 0.25 indicates Negative momentum. The RSI at 59.56 is Neutral, neither overbought nor oversold. The STOCH value of 86.01 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for FGEN.

FibroGen Risk Analysis

FibroGen disclosed 72 risk factors in its most recent earnings report. FibroGen reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

FibroGen Peers Comparison

Overall Rating
UnderperformOutperform
Sector (65)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
65
Neutral
¥347.74B11.06-2.99%2.56%11.77%-10.16%
61
Neutral
$37.35M-73.11%-60.20%3.85%
49
Neutral
$47.54M-136.13%61.43%
47
Neutral
$30.92M60.38%-38.60%95.86%
46
Neutral
$46.46M-14.91%75.74%
38
Underperform
$80.95M78.50%55.52%
$20.43M-25.40%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
FGEN
FibroGen
7.65
-23.85
-75.71%
GRCE
Grace Therapeutics
3.36
0.46
15.86%
LVTX
LAVA Therapeutics
1.42
-0.60
-29.70%
RNXT
RenovoRx
1.30
0.12
10.17%
INKT
MiNK Therapeutics
20.31
11.31
125.67%
OSRH
OSR Holdings
1.06
-9.78
-90.22%

FibroGen Corporate Events

Private Placements and FinancingBusiness Operations and Strategy
FibroGen Amends Financing Agreement with Morgan Stanley
Neutral
Jul 14, 2025

On July 14, 2025, FibroGen amended its financing agreement with Morgan Stanley Tactical Value, reducing the minimum cash balance requirement from $22.5 million to $18.75 million. This adjustment may impact FibroGen’s financial flexibility and operational strategies, potentially influencing its market positioning and stakeholder interests.

The most recent analyst rating on (FGEN) stock is a Sell with a $0.60 price target. To see the full list of analyst forecasts on FibroGen stock, see the FGEN Stock Forecast page.

M&A TransactionsBusiness Operations and Strategy
FibroGen Enters New Agreement with HiFiBiO
Neutral
Jun 13, 2025

On June 12, 2025, FibroGen entered into a Termination, Asset Transfer and License Agreement with HiFiBiO Inc., ending their previous Exclusive License and Option Agreement. Under the new agreement, FibroGen has licensed its anti-CCR8 and anti-Gal-9 intellectual property to HiFiBiO, with potential financial benefits from sublicensing and commercialization revenues.

The most recent analyst rating on (FGEN) stock is a Sell with a $0.60 price target. To see the full list of analyst forecasts on FibroGen stock, see the FGEN Stock Forecast page.

Delistings and Listing ChangesStock Split
FibroGen Announces Reverse Stock Split Effective June 16
Neutral
Jun 12, 2025

On June 10, 2025, FibroGen, Inc. announced a 1-for-25 reverse stock split of its common stock, effective June 16, 2025. This move aims to increase the stock’s market price to meet Nasdaq’s listing requirements, reducing the number of outstanding shares significantly. The reverse split was approved by stockholders on June 4, 2025, and will affect all outstanding shares and equity incentive plans. Trading on a split-adjusted basis will begin on June 17, 2025.

The most recent analyst rating on (FGEN) stock is a Sell with a $0.60 price target. To see the full list of analyst forecasts on FibroGen stock, see the FGEN Stock Forecast page.

Executive/Board ChangesPrivate Placements and Financing
FibroGen Amends Financing Agreement for Flexibility
Neutral
Jun 9, 2025

On June 5, 2025, FibroGen amended its financing agreement with Morgan Stanley Tactical Value, reducing its required minimum cash balance from $27 million to $22.5 million, potentially enhancing its financial flexibility. Additionally, on June 4, 2025, FibroGen appointed Dr. Michael Kauffman to its Board of Directors, bringing his extensive oncology expertise to the company, while Dr. Aoife Brennan resigned from the board, with no disagreements cited.

The most recent analyst rating on (FGEN) stock is a Sell with a $0.60 price target. To see the full list of analyst forecasts on FibroGen stock, see the FGEN Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 18, 2025