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Pharma Mar SA (ES:PHM)
BME:PHM

Pharma Mar SA (PHM) AI Stock Analysis

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ES:PHM

Pharma Mar SA

(BME:PHM)

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Outperform 71 (OpenAI - 5.2)
Rating:71Outperform
Price Target:
€86.00
▲(2.14% Upside)
Action:ReiteratedDate:03/04/26
The score is driven primarily by improving financial performance (TTM rebound in growth, profitability, and free cash flow) and a constructive earnings outlook with meaningful regulatory and pipeline catalysts. Offsetting this are historically volatile cash flows/earnings and only moderate technical strength, while valuation appears reasonable but not deeply discounted.
Positive Factors
Revenue and Profit Rebound
A durable recovery in top-line and margins indicates the business can convert regulatory and commercial wins into recurring revenue streams. Strong 2025 growth reflects diversified revenue sources (sales, royalties, licensing), improving predictability versus prior down cycles and supporting continued reinvestment.
Cash Generation and Balance Sheet
Material positive operating cash flow and sizeable cash reserves provide durable funding for launches, R&D, and potential bolt-on deals without heavy new leverage. This strengthens financial optionality and lowers refinancing pressure while enabling measured capital allocation over the next several quarters.
Regulatory and Pipeline Catalysts
Clear near‑term regulatory milestones and active pivotal trials (LAGOON, SaLuDo, PM54/PM534) create structural upside to the commercial base. Successful approvals and trial readouts would expand addressable markets and lengthen revenue runways beyond current products.
Negative Factors
Earnings and Cash-Flow Volatility
Historically large swings in revenue and FCF reduce the predictability of earnings and capital planning. This structural variability raises execution risk for launches, complicates long-term budgeting, and can require higher cash buffers or contingent funding during negative cycles.
Dependence on Partners for Commercialization
Heavy partner reliance limits PharmaMar's control over market rollout, disclosures and timing. This structural dependency can mute upside, create asymmetric information, and expose revenue to partner performance, contract terms, and inventory/distribution decisions outside company control.
Generic Competition Risk for Yondelis
Established generics in Europe and uncertain U.S. patent outcomes pose a durable headwind to royalty and sales streams from Yondelis. This structural erosion risk can compress long‑term revenue and margins, increasing reliance on new approvals and pipeline commercialization to replace lost cash flows.

Pharma Mar SA (PHM) vs. iShares MSCI Spain ETF (EWP)

Pharma Mar SA Business Overview & Revenue Model

Company DescriptionPharma Mar, S.A., a biopharmaceutical company, engages in the research, development, production, and commercialization of bio-active principles of marine origin for use in oncology in Spain, Italy, Germany, Ireland, rest of EU, the United States, and internationally. The company operates through three segments: Oncology, Diagnostics, and RNA interference. It develops and commercializes Yondelis for the treatment of soft tissue sarcomas and for ovarian cancer; Aplidin for treating multiple myeloma; and Zepzelca for treating patients with small cell lung cancer. The company also develops PM14 which is in phase II clinical trails for the treatment of solid tumors. In addition, it develops and markets diagnostics kits; and develops drugs with therapeutic activity based on reducing or silencing gene expression. The company was incorporated in 1986 and is based in Madrid, Spain.
How the Company Makes MoneyPharma Mar generates revenue primarily through the sales of its pharmaceutical products, particularly Aplidin and other oncology-related therapies. The company has established a revenue model that includes direct sales to healthcare providers and collaborations with other pharmaceutical companies for the development and commercialization of its drugs. Key revenue streams include royalties from licensing agreements, milestone payments from partners upon achieving specific development or sales targets, and potential product sales in various international markets. Additionally, Pharma Mar has engaged in strategic partnerships with major pharmaceutical companies to enhance its research capabilities and market reach, contributing to its earnings through collaborative development agreements.

Pharma Mar SA Earnings Call Summary

Earnings Call Date:Mar 02, 2026
(Q4-2025)
|
% Change Since: |
Next Earnings Date:Apr 23, 2026
Earnings Call Sentiment Positive
The call communicated a strong set of financial results and clear strategic progress—notably robust revenue growth (+27% y/y), a material improvement in profitability (EBITDA ~5x; net income +187%), healthy cash generation (EUR 53m) and multiple regulatory/commercial advances for Zepzelca and other assets. Pipeline momentum (LAGOON, SaLuDo, PM54, PM534) and licensing deals (e.g., Merck for Japan) provide additional upside. Offsetting factors include a 12% decline in U.S. Zepzelca royalties driven by FX and competition, outstanding pricing/reimbursement negotiations in Europe, exposure to partner-controlled disclosures, generics risk for Yondelis, and planned increases in commercial spending. Overall, positive operational and financial trends materially outweigh the identified risks, though execution on European launches and partner dynamics will be key to sustaining momentum.
Q4-2025 Updates
Positive Updates
Strong Top-Line Growth
Total revenues grew 27% year-on-year in 2025, driven by increased sales, royalties and licensing income (sales +20%, royalties +4%, licensing revenues +66%).
Major Profitability Improvement
EBITDA reached approximately EUR 68 million (~5x the 2024 level) and net income increased 187% year-on-year to EUR 75 million.
Cash Generation and Balance Sheet Strength
Operating cash flow of EUR 53 million; year-end cash and financial investments of EUR 168 million while net debt remained at levels similar to 2024, supporting ongoing projects and optional capital allocation (EUR 34 million spent on share buybacks in 2025).
Regulatory and Commercial Milestones for Zepzelca
U.S. approval in October 2025 for first-line maintenance use; approval also obtained in Switzerland; European regulatory dossier submitted with EMA opinion expected in Q1 2026 and potential commercial launches in some EU countries in H2 2026.
Commercial Momentum for Key Products
Zepzelca growth observed in Switzerland and France (+31% cited for France/early use model); Yondelis raw material sales to partners up 20% and Yondelis royalties in the U.S. more than doubled versus 2024; Yondelis unit sales in Europe grew ~4% despite generic entrants.
Clinical Pipeline Progress and Upcoming Catalysts
Pivotal trials LAGOON and SaLuDo progressing on schedule (LAGOON top-line expected H2 2026; SaLuDo enrollment completion H1 2026, results H1 2027). PM54 reached recommended dose; IND cleared for PM54 combination trial with immunotherapy and trial start expected in H1 2026. PM534 in dose escalation with planned expansion in H2 2026.
Negative Updates
Decline in U.S. Zepzelca Royalties
Zepzelca royalties in the U.S. decreased 12% year-on-year in 2025, driven by a negative FX impact (Euro–USD ~ -7.5%) and the entry of a new competitor.
Pricing and Reimbursement Uncertainty in Europe
European pricing and reimbursement processes remain pending (e.g., Switzerland negotiations ongoing, expected mid-2026); sensitivity around timing and price outcomes could delay or limit early European revenue realization even after EMA approval.
Exposure to Partner Disclosures and Limited Transparency
Significant reliance on partners (Jazz, J&J, Merck) for commercial execution and regulatory filings in key territories; management cannot disclose partner projections or certain commercial details (inventory, U.S. sales expectations), which increases external uncertainty.
Generic Competition and Patent/Market Risk
Yondelis faces generic competition in Europe (six approved generic versions), and the timing and impact of potential U.S. generics remain uncertain—creating downside risk to future royalties despite recent growth.
Rising Commercial Costs and Near-Term Expense Increase
Operating/commercial expenses increased slightly in 2025 due to launch preparation, and management expects commercial expenditure to grow around 30% over the next two years, which could pressure margins near-term as launches scale.
Company Guidance
PharmaMar guided for continued 2026 top‑line growth driven by a likely European approval for Zepzelca (EMA opinion expected Q1 2026 with some EU launches possible in H2 2026), expecting U.S. and European sales and royalties to rise next year; commercial spend is projected to increase ~30% over the next two years while R&D should remain roughly flat versus 2025 (≈€95m). Key development milestones and timelines include LAGOON topline in H2 2026 (potential second‑line filing in H2 2026 if positive), SaLuDo enrollment completion in H1 2026 with results in H1 2027 (possible approval in 2028), PM54 having reached recommended dose with an IND cleared for an immunotherapy combo and trial start expected H1 2026 (data slated for ESMO Oct 2026), and PM534 expansion planned in H2 2026. This guidance is supported by strong 2025 results—revenues +27% YoY, EBITDA ≈€68m (~5x 2024), net income €75m (+187% YoY), operating cash flow €53m, cash & financial investments €168m and debt roughly stable to 2024—and positive commercial signals such as a 13% QoQ uplift after the October U.S. approval, +31% growth in France, Yondelis raw material sales +20%, U.S. royalties more than doubled vs 2024 and European unit sales +4%.

Pharma Mar SA Financial Statement Overview

Summary
TTM results show a clear rebound with faster revenue growth, improved profitability, stronger returns, and meaningful free cash flow alongside modest leverage. The main drag is multi-year volatility in earnings and cash flow (notably weaker/negative periods in 2023–2024), indicating less stable earnings power.
Income Statement
78
Positive
Profitability is strong in TTM (Trailing-Twelve-Months), with very high gross profit and improved operating profitability versus 2024. Revenue growth accelerated meaningfully in TTM, and net income rose sharply. The main weakness is volatility across the cycle: revenue contracted in 2021–2022 and 2023 profitability was near break-even/negative at the operating level, highlighting sensitivity to product/mix or cost swings.
Balance Sheet
74
Positive
Leverage looks conservative with low debt relative to equity across periods, and equity has grown versus 2020, supporting balance-sheet resilience. Returns on equity recovered to solid levels in TTM after a weak 2023. The key risk is variability in shareholder returns year-to-year (including an unusually high 2020 return level that didn’t persist), which suggests earnings power is not fully stable.
Cash Flow
66
Positive
Cash generation improved substantially in TTM (Trailing-Twelve-Months) with positive operating cash flow and solid free cash flow, a major turnaround from 2024’s negative free cash flow and 2023’s cash burn. Free cash flow is a reasonable share of net income in TTM. The main concern is inconsistency: cash flows have swung dramatically (including very strong 2020, then materially weaker/negative 2023–2024), indicating higher execution and working-capital or investment timing risk.
BreakdownDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue221.39M174.85M158.15M196.34M229.83M
Gross Profit209.13M166.67M148.54M182.70M213.39M
EBITDA48.30M21.23M4.55M52.07M104.08M
Net Income74.99M26.13M1.14M49.36M92.86M
Balance Sheet
Total Assets395.08M349.64M340.52M393.26M368.39M
Cash, Cash Equivalents and Short-Term Investments167.22M154.53M162.56M182.42M201.88M
Total Debt50.55M51.08M43.67M42.63M49.33M
Total Liabilities142.53M141.28M147.08M170.30M190.47M
Stockholders Equity251.83M208.36M193.44M222.96M177.92M
Cash Flow
Free Cash Flow43.75M-9.48M-29.40M29.47M17.87M
Operating Cash Flow53.13M6.03M-13.45M38.32M25.68M
Investing Cash Flow-60.79M1.03M-43.05M10.88M18.47M
Financing Cash Flow-36.52M-5.35M-32.14M-13.37M-27.41M

Pharma Mar SA Technical Analysis

Technical Analysis Sentiment
Positive
Last Price84.20
Price Trends
50DMA
78.28
Positive
100DMA
77.15
Positive
200DMA
80.44
Positive
Market Momentum
MACD
0.82
Negative
RSI
66.38
Neutral
STOCH
75.81
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ES:PHM, the sentiment is Positive. The current price of 84.2 is above the 20-day moving average (MA) of 78.11, above the 50-day MA of 78.28, and above the 200-day MA of 80.44, indicating a bullish trend. The MACD of 0.82 indicates Negative momentum. The RSI at 66.38 is Neutral, neither overbought nor oversold. The STOCH value of 75.81 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ES:PHM.

Pharma Mar SA Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
78
Outperform
€1.54B15.3714.89%3.51%11.04%8.29%
72
Outperform
€4.21B30.8620.70%1.50%-9.39%-25.92%
71
Outperform
$1.49B18.4217.22%1.04%7.35%5375.64%
65
Neutral
€210.71M47.712.03%1.91%-1.19%-54.66%
59
Neutral
€2.66B59.711.45%1.22%13.32%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ES:PHM
Pharma Mar SA
78.00
-12.55
-13.86%
ES:ALM
Almirall
12.02
2.36
24.46%
ES:FAE
Faes Farma
4.78
1.51
46.20%
ES:GRF.P
Grifols
7.37
-0.38
-4.93%
ES:RJF
LABORATORIO REIG JOFRE
2.48
-0.14
-5.49%
ES:ROVI
Laboratorios Farmaceuticos Rovi
81.50
28.33
53.29%

Pharma Mar SA Corporate Events

Pharma Mar Continues Share Buyback With February Purchases on Madrid Exchange
Mar 3, 2026

Pharma Mar SA has continued its previously announced share buyback programme, disclosing purchases of its own shares on the Madrid Stock Exchange between 1 and 28 February 2026 at average prices generally ranging from about €75 to €79 per share. The transactions, executed through JB Capital Markets as intermediary, form part of the company’s ongoing capital management strategy, potentially supporting the stock price and signaling management’s confidence in the business to investors.

The latest tranche of repurchases adds to the buyback that began in October 2025 and indicates a sustained commitment to returning value to shareholders through reductions in free float or treasury stock usage for corporate purposes. For stakeholders, the continued pace and pricing of these acquisitions provide insight into how Pharma Mar is allocating cash and how it views its current market valuation relative to its long-term prospects.

The most recent analyst rating on (ES:PHM) stock is a Buy with a EUR120.00 price target. To see the full list of analyst forecasts on Pharma Mar SA stock, see the ES:PHM Stock Forecast page.

Pharma Mar Details January Transactions in Ongoing Share Buyback Programme
Feb 3, 2026

Pharma Mar has continued its previously announced share buyback programme, reporting a series of own-share purchases on the Madrid stock exchange between 1 and 31 January 2026. Over the month, the company executed multiple daily transactions through intermediary JB Capital Markets, acquiring relatively small blocks of shares at average prices generally in the high-70 to low-80 euro range. The operation underscores Pharma Mar’s ongoing capital management strategy and signals confidence in its valuation, with the incremental repurchases potentially supporting earnings per share and providing additional liquidity to shareholders who choose to sell into the programme.

The most recent analyst rating on (ES:PHM) stock is a Hold with a EUR79.00 price target. To see the full list of analyst forecasts on Pharma Mar SA stock, see the ES:PHM Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Mar 04, 2026