Investor Sentiment And Short InterestRelatively high short interest in the float, reported in the mid-teens, signals investor skepticism that could amplify downside pressure on the share price.
Pharmacokinetic Exposure RiskInstances of lower-than-target serum concentrations in certain dosing scenarios indicate a risk of underexposure that may blunt clinical effect and jeopardize efficacy readouts.
Phase III Dose-selection UncertaintyQuestions regarding Phase III dose selection, including the addition of a less frequent dosing arm, create uncertainty about the optimal regimen and could complicate regulatory discussions.