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Collplant Holdings (CLGN)
NASDAQ:CLGN
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Collplant Holdings (CLGN) AI Stock Analysis

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CLGN

Collplant Holdings

(NASDAQ:CLGN)

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Neutral 40 (OpenAI - 4o)
Rating:40Neutral
Price Target:
$2.00
▼(-4.76% Downside)
Collplant Holdings' overall stock score is primarily impacted by its poor financial performance, characterized by significant revenue and cash flow declines and negative profit margins. Technical analysis also indicates a bearish trend, while valuation metrics highlight the company's unprofitability. These factors collectively suggest a high-risk investment without immediate signs of improvement.
Positive Factors
Distribution Expansion
The expansion into North America with a new logistics hub enhances CollPlant's market reach and logistical efficiency, supporting long-term growth in the U.S. and Canada.
Innovative Product Development
The development of a 3D bioprinted skin model using rhCollagen positions CollPlant as a leader in regenerative medicine, offering sustainable solutions for cosmetic and pharmaceutical testing.
Product Performance
Superior performance of CollPlant's BioInk in studies enhances its credibility and potential adoption in tissue engineering, supporting long-term market competitiveness.
Negative Factors
Revenue Decline
Significant revenue decline poses a challenge to financial stability and growth, necessitating strategic adjustments to improve financial performance.
Negative Cash Flow
Sustained negative cash flow limits CollPlant's ability to fund operations and invest in growth, impacting long-term financial health and operational flexibility.
Shrinking Equity
Decreasing equity and a lower equity ratio indicate weakening financial stability, which could affect CollPlant's ability to secure financing and sustain operations.

Collplant Holdings (CLGN) vs. SPDR S&P 500 ETF (SPY)

Collplant Holdings Business Overview & Revenue Model

Company DescriptionCollPlant Holdings (CLGN) is a biotechnology company focused on developing and commercializing innovative regenerative medicine products based on its proprietary recombinant human collagen technology. The company operates primarily in the biotechnology and medical sectors, with a core emphasis on wound healing, tissue regeneration, and aesthetic applications. CollPlant's flagship products include its collagen-based solutions for skin and soft tissue repair, as well as its advanced aesthetic treatments that leverage collagen's biocompatibility and functionality.
How the Company Makes MoneyCollPlant generates revenue through the commercialization of its proprietary collagen products and technologies. The company's primary revenue streams include direct sales of its wound healing and tissue regeneration products to hospitals, clinics, and healthcare providers, as well as licensing agreements with strategic partners in the medical and aesthetic industries. Significant partnerships with key players in the biotechnology and medical device sectors enhance its market reach and facilitate product development. Additionally, CollPlant may receive milestone payments and royalties from its partners based on the commercial success of collaborative products, further contributing to its earnings.

Collplant Holdings Earnings Call Summary

Earnings Call Date:Mar 26, 2025
(Q4-2024)
|
% Change Since: |
Next Earnings Date:Apr 02, 2026
Earnings Call Sentiment Neutral
Despite significant advancements in preclinical programs and continued collaboration with AbbVie, the company experienced a sharp decline in annual revenue and increased net losses, presenting a mixed financial outlook.
Q4-2024 Updates
Positive Updates
Photocurable Dermal Filler Preclinical Success
The photocurable dermal filler candidate is in the preclinical phase, targeting a market valued at approximately $6.3 billion with a compound annual growth rate of 10%. Positive feedback from leaders in aesthetic medicine suggests it could be a game-changer for facial plastic surgery.
Regenerative Breast Implant Program Progress
Preclinical testing of commercial-sized breast implants (250cc) shows promising outcomes with depolarization and rapid tissue ingrowth, no complications, and maintained volume retention. This product could revolutionize breast reconstruction and aesthetic enhancements.
AbbVie Collaboration and Financial Milestone
CollPlant received a $2 million payment from AbbVie following development achievements in their dermal filler clinical trials, indicative of continued collaboration and potential future milestones.
Cash Runway Stability
Cash and cash equivalents as of December 31, 2024, were $11.9 million, with an expected operational runway through the second quarter of 2026.
Negative Updates
Significant Revenue Decline
Revenue for the year ended December 31, 2024, was $515,000, a sharp decrease from $11 million in 2023, mainly due to a $10 million milestone payment in 2023 not repeated in 2024.
Increased Net Loss
GAAP net loss for the year ended December 31, 2024, was $16.6 million compared to a net loss of $7 million for the year 2023, highlighting increased financial strain.
Company Guidance
During the CollPlant Biotechnologies Ltd. investor call, CEO Yehiel Tal and Deputy CEO Eran Rotem provided guidance centered on their regenerative medicine advancements, notably highlighting their proprietary photocurable dermal filler and regenerative breast implant programs. The dermal filler, aimed at a market valued at approximately $6.3 billion with a 10% CAGR, is currently in the preclinical phase, with plans to launch a clinical trial within two years. The regenerative breast implant program is progressing with preclinical testing of 250cc commercial-sized prototypes, showing promising results in tissue integration without complications. Financially, CollPlant reported a decrease in revenue from $11 million in 2023 to $515,000 in 2024, primarily due to a $10 million milestone payment from AbbVie in 2023. Despite a GAAP net loss of $16.6 million in 2024 compared to $7 million in 2023, the company maintains a stable cash position of $11.9 million as of December 31, 2024, not accounting for an additional $2 million payment from AbbVie, ensuring operational capability into the second quarter of 2026.

Collplant Holdings Financial Statement Overview

Summary
Collplant Holdings is facing severe financial challenges with significant revenue and cash flow declines, negative profit margins, and shrinking assets and equity. Despite low debt levels, the company's ability to generate revenue and positive cash flow is a major concern.
Income Statement
35
Negative
Collplant Holdings has experienced significant revenue volatility, with a notable revenue decline from $10.96 million in 2023 to $0.515 million in 2024. The company is struggling with negative margins, including a gross profit margin of -215% and a net profit margin of -3226% in 2024. Despite a brief profitable period in 2021, consistent negative EBIT and EBITDA margins indicate ongoing operational challenges.
Balance Sheet
50
Neutral
The company's debt-to-equity ratio remains low at 0.23 in 2024, reflecting a conservative leverage approach. However, stockholders' equity has decreased significantly, and the equity ratio has dropped from 88% in 2021 to 72% in 2024, indicating weakening financial stability. The company's asset base has also shrunk considerably over the same period.
Cash Flow
30
Negative
Collplant Holdings' free cash flow has deteriorated significantly, with a negative free cash flow of $14.58 million in 2024, compared to $3.72 million in 2023. The operating cash flow to net income ratio and free cash flow to net income ratio are both negative, showing a lack of cash flow generation. Despite previous years of positive cash flow from financing activities, the company's cash reserves are depleting.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue2.48M515.00K10.96M299.00K15.64M6.14M
Gross Profit622.00K-2.15M7.87M-1.18M13.64M2.68M
EBITDA-11.05M-15.55M-5.91M-15.81M1.05M-5.08M
Net Income-12.16M-16.61M-7.02M-16.93M237.00K-5.77M
Balance Sheet
Total Assets14.09M18.71M34.13M37.77M51.22M10.84M
Cash, Cash Equivalents and Short-Term Investments8.55M11.91M26.67M29.65M43.30M3.33M
Total Debt2.94M3.08M3.16M2.91M3.61M3.39M
Total Liabilities4.78M5.25M5.79M5.49M6.10M6.36M
Stockholders Equity9.30M13.46M28.34M32.28M45.12M4.48M
Cash Flow
Free Cash Flow-10.02M-14.58M-3.72M-14.97M1.07M-4.89M
Operating Cash Flow-9.95M-14.09M-2.76M-13.70M2.50M-4.45M
Investing Cash Flow-70.00K-539.00K-1.16M28.92M-31.56M-519.00K
Financing Cash Flow3.10M9.00K1.11M1.87M38.76M4.46M

Collplant Holdings Technical Analysis

Technical Analysis Sentiment
Negative
Last Price2.10
Price Trends
50DMA
2.28
Negative
100DMA
2.40
Negative
200DMA
2.36
Negative
Market Momentum
MACD
-0.03
Negative
RSI
43.23
Neutral
STOCH
52.53
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLGN, the sentiment is Negative. The current price of 2.1 is below the 20-day moving average (MA) of 2.10, below the 50-day MA of 2.28, and below the 200-day MA of 2.36, indicating a bearish trend. The MACD of -0.03 indicates Negative momentum. The RSI at 43.23 is Neutral, neither overbought nor oversold. The STOCH value of 52.53 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CLGN.

Collplant Holdings Risk Analysis

Collplant Holdings disclosed 81 risk factors in its most recent earnings report. Collplant Holdings reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Collplant Holdings Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
52
Neutral
$33.84M-0.81-21.16%-92.42%62.37%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
$24.14M-87.18%38.42%
41
Neutral
$62.63M-390.53%61.23%
40
Neutral
$28.36M-92.74%280.77%32.82%
38
Underperform
$24.40M-4.10
30
Underperform
$25.59M-1.7831.09%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CLGN
Collplant Holdings
2.01
-1.99
-49.75%
DARE
Daré Bioscience
1.79
-1.46
-44.92%
PASG
Passage Bio
9.18
-6.32
-40.77%
PYPD
PolyPid
3.97
0.95
31.46%
SABS
SAB Biotherapeutics
3.80
0.73
23.78%
NRSN
Neurosense Therapeutics Ltd.
1.20
0.16
15.38%

Collplant Holdings Corporate Events

CollPlant Biotechnologies Announces Annual and Extraordinary General Meeting for December 2025
Nov 26, 2025

On November 26, 2025, CollPlant Biotechnologies Ltd. announced that it will hold its annual and extraordinary general meeting of shareholders on December 31, 2025, in Tel-Aviv, Israel. The meeting will address several key proposals, including the re-election of board members, re-appointment of auditors, renewal of the compensation policy for directors and officers, and the appointment of CEO Yehiel Tal as interim Chairman of the Board. The outcomes of this meeting could influence the company’s governance and strategic direction, impacting stakeholders and potentially affecting its market position.

CollPlant Biotechnologies Expands North American Operations and Reports Q3 2025 Results
Nov 26, 2025

CollPlant Biotechnologies reported its third-quarter financial results for 2025, highlighting significant advancements and strategic initiatives. The company announced the expansion of its rhCollagen and BioInk sales in North America through a new logistics partnership and commercial leadership, aiming to enhance its market presence. Recent developments include a collaboration with Mayo Clinic to create a humanized bioprinted skin model, and a comparative study showing its bioink, Collink.3D™, outperformed a leading extracellular matrix in tissue formation. Additionally, CollPlant is implementing cost-reduction measures and prioritizing its collaboration with AbbVie and the development of its dermal filler product. The company is also expanding its international distribution network for its tendon-repair product, Vergenix™ STR, into new markets.

CollPlant Expands rhCollagen Distribution in North America
Oct 27, 2025

On October 27, 2025, CollPlant Biotechnologies announced the expansion of its distribution capabilities in North America through a new partnership with a U.S.-based logistics center. This new logistics hub, which is set to become operational within the quarter, will enhance the distribution of CollPlant’s rhCollagen and BioInk products in the U.S. and Canada. The center is equipped with advanced infrastructure to ensure efficient and secure distribution, reflecting CollPlant’s commitment to the North American market and its strategy to improve logistical efficiency and customer service.

CollPlant’s BioInk Outperforms Matrigel in Technion Study
Oct 20, 2025

On October 20, 2025, CollPlant Biotechnologies announced positive results from a study conducted by the Technion – Israel Institute of Technology, which demonstrated that its rhCollagen-based bioink, Collink.3D™, outperformed Matrigel® in supporting structured tissue formation. This suggests that Collink.3D™ could serve as a next-generation, animal-free extracellular matrix for advanced tissue engineering and research applications, potentially impacting the market for basement membrane matrices, which is projected to grow significantly by 2031.

CollPlant and Mayo Clinic Unveil Humanized 3D Bioprinted Skin Model
Oct 16, 2025

On October 16, 2025, CollPlant Biotechnologies announced the development of a first-of-its-kind fully humanized 3D bioprinted human skin model by Mayo Clinic researchers, utilizing CollPlant’s rhCollagen-based bioink. This model, which serves as an alternative to animal testing, has significant implications for cosmetic and pharmaceutical testing, disease modeling, and drug development, offering a sustainable and ethical solution while advancing regenerative medicine.

CollPlant Biotechnologies Reports Positive Non-Clinical Results for Regenerative Filler
Sep 30, 2025

On September 30, 2025, CollPlant Biotechnologies announced positive results from non-clinical studies of its photocurable regenerative dermal and soft tissue filler. This product, which combines hyaluronic acid with a modified form of rhCollagen, is designed to offer both immediate and long-lasting benefits in aesthetic medicine. The successful completion of these studies marks a significant milestone for CollPlant as it prepares to advance the filler into clinical trials, potentially redefining standards in aesthetic treatments by integrating contouring precision, structural support, and tissue regeneration.

CollPlant Expands VergenixSTR Distribution in Europe
Sep 15, 2025

On September 15, 2025, CollPlant Biotechnologies announced the expansion of its European distribution network for its VergenixSTR product by signing a new agreement in Poland. VergenixSTR, a soft tissue repair matrix designed to treat tendinopathy, combines rhCollagen with platelet-rich plasma to promote tendon healing. This expansion is part of CollPlant’s strategy to broaden its global distribution network, enhancing its market presence in Europe and the Asia-Pacific region.

CollPlant Biotechnologies Transfers Listing to Nasdaq Capital Market
Sep 12, 2025

CollPlant Biotechnologies Ltd. announced that it has successfully transferred the listing of its ordinary shares from the Nasdaq Global Market to the Nasdaq Capital Market, effective September 12, 2025. This move is part of the company’s strategic efforts to optimize its market positioning while maintaining the trading symbol ‘CLGN’. The transfer is expected to have no impact on the trading of its shares, ensuring continuity for investors and stakeholders.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 22, 2025