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CollPlant Biotechnologies Ltd. (CLGN)
:CLGN
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Collplant Holdings (CLGN) AI Stock Analysis

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CLGN

Collplant Holdings

(NASDAQ:CLGN)

Rating:44Neutral
Price Target:
$2.50
▼(-0.79% Downside)
Collplant Holdings' overall stock score is primarily impacted by its poor financial performance, characterized by significant revenue and cash flow declines and negative profit margins. Technical analysis provides a neutral outlook, while valuation metrics indicate potential overvaluation due to negative earnings. The lack of earnings call and corporate events data limits further insights.
Positive Factors
Partnerships
CollPlant continues to progress the clinical development of its dermal and soft-tissue filler program in collaboration with AbbVie.
Product Development
Encouraging initial breast implant data shows signs of implant integration and rapid growth of native tissue, supporting potential future commercialization.
Negative Factors
Financial Performance
The company reported total revenues of $0.25M, compared to the consensus estimate of $0.69M.

Collplant Holdings (CLGN) vs. SPDR S&P 500 ETF (SPY)

Collplant Holdings Business Overview & Revenue Model

Company DescriptionCollPlant Biotechnologies Ltd., a regenerative and aesthetic medicine company, focuses on three-dimensional (3D) bioprinting of tissues and organs, and medical aesthetics in the United States, Canada, and Europe. Its products are based on recombinant type I human collagen that is produced with its proprietary plant based genetic engineering technology. The company's products include BioInks for 3D printing of tissues and organs; dermal filler and soft tissue fillers for treating wrinkles; 3D Bioprinted breast implants for regeneration of breast tissue; injectable implants to promote breast tissue regeneration; 3D bioprinted regenerative soft tissue matrix; VergenixSTR, a soft tissue repair matrix intended for the treatment of tendinopathy; and VergenixFG, an advanced wound care product for the treatment of deep surgical incisions and wounds, including diabetic ulcers, venous and pressure ulcers, burns, bedsores, and other chronic wounds. It has collaboration agreements with 3D Systems Corporation; CellInk, a BICO Group company; Advanced Regenerative Manufacturing Institute; RegenMed Development Organization; Israel's Technion Institute of Technology; AbbVie; and STEMCELL. The company was formerly known as CollPlant Holdings Ltd. and changed its name to CollPlant Biotechnologies Ltd. in June 2019. CollPlant Biotechnologies Ltd. was founded in 2004 and is headquartered in Rehovot, Israel.
How the Company Makes MoneyCollplant generates revenue through the commercialization of its collagen-based products and therapies. Its primary revenue streams include sales of medical devices and therapeutic products designed for wound care and tissue regeneration. Additionally, the company may engage in strategic partnerships with other healthcare firms, research institutions, and pharmaceutical companies to co-develop products or license its technology, further enhancing its revenue potential. Collaborations and partnerships may also provide funding through grants or milestone payments, contributing to its overall earnings. The company's focus on developing novel applications of its collagen technology positions it to capitalize on growing market demands in the regenerative medicine field.

Collplant Holdings Earnings Call Summary

Earnings Call Date:Aug 20, 2025
(Q4-2024)
|
% Change Since: 2.44%|
Next Earnings Date:Nov 26, 2025
Earnings Call Sentiment Neutral
Despite significant advancements in preclinical programs and continued collaboration with AbbVie, the company experienced a sharp decline in annual revenue and increased net losses, presenting a mixed financial outlook.
Q4-2024 Updates
Positive Updates
Photocurable Dermal Filler Preclinical Success
The photocurable dermal filler candidate is in the preclinical phase, targeting a market valued at approximately $6.3 billion with a compound annual growth rate of 10%. Positive feedback from leaders in aesthetic medicine suggests it could be a game-changer for facial plastic surgery.
Regenerative Breast Implant Program Progress
Preclinical testing of commercial-sized breast implants (250cc) shows promising outcomes with depolarization and rapid tissue ingrowth, no complications, and maintained volume retention. This product could revolutionize breast reconstruction and aesthetic enhancements.
AbbVie Collaboration and Financial Milestone
CollPlant received a $2 million payment from AbbVie following development achievements in their dermal filler clinical trials, indicative of continued collaboration and potential future milestones.
Cash Runway Stability
Cash and cash equivalents as of December 31, 2024, were $11.9 million, with an expected operational runway through the second quarter of 2026.
Negative Updates
Significant Revenue Decline
Revenue for the year ended December 31, 2024, was $515,000, a sharp decrease from $11 million in 2023, mainly due to a $10 million milestone payment in 2023 not repeated in 2024.
Increased Net Loss
GAAP net loss for the year ended December 31, 2024, was $16.6 million compared to a net loss of $7 million for the year 2023, highlighting increased financial strain.
Company Guidance
During the CollPlant Biotechnologies Ltd. investor call, CEO Yehiel Tal and Deputy CEO Eran Rotem provided guidance centered on their regenerative medicine advancements, notably highlighting their proprietary photocurable dermal filler and regenerative breast implant programs. The dermal filler, aimed at a market valued at approximately $6.3 billion with a 10% CAGR, is currently in the preclinical phase, with plans to launch a clinical trial within two years. The regenerative breast implant program is progressing with preclinical testing of 250cc commercial-sized prototypes, showing promising results in tissue integration without complications. Financially, CollPlant reported a decrease in revenue from $11 million in 2023 to $515,000 in 2024, primarily due to a $10 million milestone payment from AbbVie in 2023. Despite a GAAP net loss of $16.6 million in 2024 compared to $7 million in 2023, the company maintains a stable cash position of $11.9 million as of December 31, 2024, not accounting for an additional $2 million payment from AbbVie, ensuring operational capability into the second quarter of 2026.

Collplant Holdings Financial Statement Overview

Summary
Collplant Holdings is facing severe financial challenges, including substantial revenue drops, negative profit margins, and deteriorating cash flows. Despite low debt levels, the company's declining assets and equity suggest significant financial instability.
Income Statement
35
Negative
Collplant Holdings has experienced significant revenue volatility, with a notable revenue decline from $10.96 million in 2023 to $0.515 million in 2024. The company is struggling with negative margins, including a gross profit margin of -215% and a net profit margin of -3226% in 2024. Despite a brief profitable period in 2021, consistent negative EBIT and EBITDA margins indicate ongoing operational challenges.
Balance Sheet
50
Neutral
The company's debt-to-equity ratio remains low at 0.23 in 2024, reflecting a conservative leverage approach. However, stockholders' equity has decreased significantly, and the equity ratio has dropped from 88% in 2021 to 72% in 2024, indicating weakening financial stability. The company's asset base has also shrunk considerably over the same period.
Cash Flow
30
Negative
Collplant Holdings' free cash flow has deteriorated significantly, with a negative free cash flow of $14.58 million in 2024, compared to $3.72 million in 2023. The operating cash flow to net income ratio and free cash flow to net income ratio are both negative, showing a lack of cash flow generation. Despite previous years of positive cash flow from financing activities, the company's cash reserves are depleting.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue515.00K10.96M299.00K15.64M6.14M
Gross Profit-1.11M8.97M-101.00K13.64M3.13M
EBITDA-16.21M-6.41M-16.02M838.00K-4.94M
Net Income-16.61M-7.02M-16.75M409.00K-5.81M
Balance Sheet
Total Assets18.71M34.13M37.77M51.22M10.84M
Cash, Cash Equivalents and Short-Term Investments11.91M26.67M29.65M43.30M3.33M
Total Debt3.08M3.16M2.91M3.61M3.39M
Total Liabilities5.25M5.79M5.49M6.10M6.36M
Stockholders Equity13.46M28.34M32.28M45.12M4.48M
Cash Flow
Free Cash Flow-14.58M-3.72M-15.01M912.00K-4.97M
Operating Cash Flow-14.09M-2.76M-13.70M2.50M-4.45M
Investing Cash Flow-539.00K-1.16M28.92M-31.56M-519.00K
Financing Cash Flow9.00K1.11M1.87M38.76M4.46M

Collplant Holdings Technical Analysis

Technical Analysis Sentiment
Positive
Last Price2.52
Price Trends
50DMA
2.01
Positive
100DMA
2.11
Positive
200DMA
2.90
Negative
Market Momentum
MACD
0.10
Positive
RSI
52.81
Neutral
STOCH
31.33
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLGN, the sentiment is Positive. The current price of 2.52 is below the 20-day moving average (MA) of 2.54, above the 50-day MA of 2.01, and below the 200-day MA of 2.90, indicating a neutral trend. The MACD of 0.10 indicates Positive momentum. The RSI at 52.81 is Neutral, neither overbought nor oversold. The STOCH value of 31.33 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CLGN.

Collplant Holdings Risk Analysis

Collplant Holdings disclosed 81 risk factors in its most recent earnings report. Collplant Holdings reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Collplant Holdings Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.82B-0.16-39.78%2.19%21.38%-1.56%
45
Neutral
$60.53M-87.74%-60.16%
44
Neutral
$30.52M-78.25%248.62%26.22%
41
Neutral
$35.46M-312.77%61.18%
40
Underperform
$9.52M-64.18%3.99%
39
Underperform
$55.16M-104.21%39.60%
35
Underperform
$4.79M-133.62%-86.43%-8.91%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CLGN
Collplant Holdings
2.52
-2.58
-50.59%
PYPD
PolyPid
3.50
-0.10
-2.78%
ALXO
ALX Oncology Holdings
1.17
-1.40
-54.47%
SPRBD
Spruce Biosciences
8.20
-28.56
-77.69%
ALGS
Aligos Therapeutics
10.20
-3.16
-23.65%
SNSE
Sensei Biotherapeutics
7.96
-4.62
-36.72%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 23, 2025