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CASI Pharmaceuticals (CASI)
NASDAQ:CASI

CASI Pharmaceuticals (CASI) AI Stock Analysis

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CASI

CASI Pharmaceuticals

(NASDAQ:CASI)

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Neutral 46 (OpenAI - 5.2)
Rating:46Neutral
Price Target:
$0.96
▼(-9.43% Downside)
The score is primarily weighed down by poor financial performance (declining revenue, ongoing losses, negative and worsening free cash flow, and very high leverage). Technicals are somewhat improved in the short term but remain weak versus longer-term trend levels, while valuation is difficult to support due to negative earnings and no dividend yield data.
Positive Factors
Pipeline advancement (CID-103)
Advancing CID-103 into Phase 1 studies and running parallel ITP work materially strengthens CASI's long-term growth prospects by building a diversified, clinical-stage pipeline. Successful development would create new commercial opportunities beyond legacy oncology sales and reduce single-product dependency.
Secured targeted financing for development
The $20M tranche financing provides tangible runway to execute key clinical and formulation programs, preserving development momentum. Access to committed capital for R&D reduces near-term liquidity pressure and enables progress on value-driving milestones that underpin longer-term commercial potential.
Board governance strengthening
Installing an experienced non-executive chairman signals a governance uplift and clearer strategic oversight. Stronger board leadership can improve execution discipline, capital allocation decisions and stakeholder credibility—benefits that support durable operational improvement and investor confidence.
Negative Factors
Loss of China commercial access (FOLOTYN)
Regulatory denial and halted FOLOTYN sales in China eliminate a material revenue stream and fracture the company’s commercial footprint in a large market. This structural loss pressures top-line sustainability, complicates partner relationships, and may force asset divestiture or prolonged legal disputes.
Persistently negative free cash flow
Chronic operating cash burn erodes liquidity and forces reliance on external financing to fund operations and trials. Over the medium term this constrains strategic flexibility, increases financing costs or dilution risk, and can delay or scale back value-creating development programs if funding gaps emerge.
Sustained revenue decline
Multi-year revenue contraction signals weakening commercial execution and shrinks the base funding internal R&D. Lower revenues reduce operating leverage, exacerbate losses, and increase dependency on capital markets or asset sales to sustain development, raising long-term execution risk.

CASI Pharmaceuticals (CASI) vs. SPDR S&P 500 ETF (SPY)

CASI Pharmaceuticals Business Overview & Revenue Model

Company DescriptionCASI Pharmaceuticals, Inc., a biopharmaceutical company, develops and commercializes therapeutics and pharmaceutical products in China, the United States, and internationally. It offers EVOMELA, an intravenous formulation of melphalan for use as a conditioning treatment prior to stem cell transplantation, and as a palliative treatment for patients with multiple myeloma. The company's product pipeline includes CNCT19, an autologous CD19 CAR-T investigative product for the treatment of patients with B-cell acute lymphoblastic leukemia (B-ALL) and B-cell non-Hodgkin lymphoma (B-NHL); BI-1206 that is in Phase I/II trial in combination with anti-PD1 therapy Keytruda for solid tumors, and in a Phase I/IIa trial in combination with MabThera (rituximab) in patients with relapsed/refractory NHL; and CB-5339, which is in Phase I clinical trial for acute myeloid leukemia and myelodysplastic syndrome. Its product pipeline also comprises CID-103 for the treatment of patients with multiple myeloma; Thiotepa, which has multiple indications including use as a conditioning treatment for various allogeneic haemopoietic stem cell transplants; and Octreotide long acting injectable formulations for the treatment of acromegaly and for the control of symptoms associated with various neuroendocrine tumors. The company has licensing agreements with Juventas Cell Therapy Ltd; BioInvent International AB; Black Belt Therapeutics Limited; and Cleave Therapeutics, Inc. It also has distribution agreements with China Resources Pharmaceutical Commercial Group International Trading Co., Ltd; Pharmathen Global BV; and Riemser Pharma GmbH. The company was formerly known as EntreMed, Inc. and changed its name to CASI Pharmaceuticals, Inc. in June 2014. CASI Pharmaceuticals, Inc. was incorporated in 1991 and is based in Rockville, Maryland.
How the Company Makes MoneyCASI Pharmaceuticals generates revenue primarily through the commercialization of its pharmaceutical products, including sales from its oncology therapies. The company may also earn income through licensing agreements, partnerships, and collaborations with larger pharmaceutical firms, which can involve upfront payments, milestone payments, and royalties on sales. Additionally, CASI may receive funding from research grants or investment capital to support its clinical development programs. Significant partnerships, particularly those that enhance its product pipeline or expand its market reach, can also contribute to its overall earnings.

CASI Pharmaceuticals Financial Statement Overview

Summary
Weak fundamentals: revenue declined from $43.1M (2022) to $28.5M (2024), profitability remains negative (EBIT and net income losses), and operating/free cash flow are persistently negative with worsening FCF. Balance sheet risk is elevated due to very high leverage (debt-to-equity 11.96) and shrinking equity, partially offset by meaningful cash holdings.
Income Statement
37
Negative
CASI Pharmaceuticals has experienced a consistent decline in total revenue, from $43.1M in 2022 to $28.5M in 2024, indicating a negative revenue growth trend. The company also has negative EBIT and net income, leading to negative profit margins. These factors contribute to a weak income statement performance.
Balance Sheet
45
Neutral
The balance sheet shows high leverage with a debt-to-equity ratio increasing to 11.96 in 2024, indicating significant financial risk. Stockholders' equity has drastically decreased over the years. However, the company maintains a significant portion of its assets in cash and cash equivalents, which provides some liquidity cushion.
Cash Flow
42
Neutral
Cash flow from operations is consistently negative, leading to negative free cash flow. The company's free cash flow has deteriorated over time, growing more negative from $-26.7M in 2022 to $-29.5M in 2024. While financing activities have provided some cash inflow, this is not sustainable long-term. The operating cash flow to net income ratio is poor, reflecting inefficiencies in converting sales into cash.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue26.85M28.54M33.88M43.11M30.17M15.14M
Gross Profit9.61M11.15M20.05M27.28M17.61M5.63M
EBITDA-41.37M-34.87M-21.54M-24.07M-33.40M-31.35M
Net Income-49.38M-39.26M-26.94M-41.01M-36.65M-48.29M
Balance Sheet
Total Assets24.46M53.67M75.27M96.23M138.30M127.73M
Cash, Cash Equivalents and Short-Term Investments4.68M16.09M30.77M51.34M48.57M66.37M
Total Debt18.86M22.14M21.24M1.34M4.33M3.20M
Total Liabilities53.05M51.82M51.10M29.30M30.34M24.16M
Stockholders Equity-28.59M1.85M24.16M44.57M84.50M81.54M
Cash Flow
Free Cash Flow0.00-29.46M-22.21M-26.70M-42.34M-45.21M
Operating Cash Flow0.00-29.22M-19.97M-21.09M-26.84M-25.89M
Investing Cash Flow0.0011.24M-9.67M31.16M-20.69M-20.72M
Financing Cash Flow0.0015.43M-907.00K-3.27M29.64M47.15M

CASI Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.06
Price Trends
50DMA
0.95
Positive
100DMA
1.30
Negative
200DMA
1.54
Negative
Market Momentum
MACD
0.01
Negative
RSI
51.08
Neutral
STOCH
67.97
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CASI, the sentiment is Negative. The current price of 1.06 is above the 20-day moving average (MA) of 0.99, above the 50-day MA of 0.95, and below the 200-day MA of 1.54, indicating a neutral trend. The MACD of 0.01 indicates Negative momentum. The RSI at 51.08 is Neutral, neither overbought nor oversold. The STOCH value of 67.97 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CASI.

CASI Pharmaceuticals Risk Analysis

CASI Pharmaceuticals disclosed 49 risk factors in its most recent earnings report. CASI Pharmaceuticals reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

CASI Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$15.80M-0.3126.20%-42.26%
46
Neutral
$4.85M-0.06-377.44%8.52%79.51%
45
Neutral
$11.61M-0.2413.56%52.92%
45
Neutral
$13.21M-0.0779.31%
43
Neutral
$9.39M-1.52-79.47%-99.97%35.59%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CASI
CASI Pharmaceuticals
0.99
-1.56
-61.18%
CRIS
Curis
0.87
-2.60
-74.90%
GOVX
GeoVax Labs
2.63
-40.87
-93.95%
MBRX
Moleculin Biotech
4.19
-26.56
-86.37%
PULM
Pulmatrix
2.60
-4.43
-63.02%

CASI Pharmaceuticals Corporate Events

CASI Pharmaceuticals Fails to Renew FOLOTYN Import License in China, Halts Sales
Jan 22, 2026

On January 22, 2026, CASI Pharmaceuticals reported that China’s National Medical Products Administration formally rejected its May 2025 application to renew the Import Drug Registration License for FOLOTYN®, following earlier correspondence from the Chinese Center for Drug Evaluation indicating the renewal would not be granted. After the prior license expired, CASI had already halted sales of FOLOTYN® in China in line with regulatory requirements, underscoring a further setback for its commercial oncology portfolio in the country amid ongoing disputes and legal proceedings over other pipeline assets, including EVOMELA® and CNCT-19.

The most recent analyst rating on (CASI) stock is a Hold with a $0.97 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

CASI Pharmaceuticals Closes Second Tranche of US$20 Million Convertible Note Financing
Jan 13, 2026

On January 13, 2026, CASI Pharmaceuticals announced it had closed the second tranche of its previously arranged US$20 million convertible note financing with ETP Global III Fund LP, a partnership controlled by Dr. Wei-Wu He, issuing a new US$5 million convertible note. The note carries a 12% annual interest rate, matures in 36 months, and may be converted into ordinary shares either at the company’s option at maturity or at the investor’s option after 90 days, with the conversion price set to a five-day volume-weighted average and capped between US$1 and US$2 per share, a structure that provides CASI with near-term funding while potentially diluting existing shareholders depending on future share price performance.

The most recent analyst rating on (CASI) stock is a Hold with a $1.00 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

CASI Pharmaceuticals Closes First US$5 Million Tranche of Convertible Note Financing
Dec 31, 2025

On December 30, 2025, CASI Pharmaceuticals announced that it had closed the first tranche of a US$20 million convertible note financing, issuing a US$5 million note to ETP Global III Fund LP, a partnership controlled by Dr. Wei-Wu He. The three-year note carries a 12% annual interest rate and is convertible into CASI ordinary shares at a price based on the volume-weighted average trading price over a five-day period, subject to a cap of US$2 and a floor of US$1 per share, with conversion rights available to CASI at maturity and to the investor from the 91st day after issuance, providing the company with near-term funding flexibility while potentially diluting existing shareholders over time.

The most recent analyst rating on (CASI) stock is a Buy with a $4.00 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

CASI Pharmaceuticals Wins Nasdaq Listing Extension to February 2026
Dec 23, 2025

On December 23, 2025, CASI Pharmaceuticals announced that a Nasdaq Hearings Panel granted the company an extension to remain listed on the Nasdaq Capital Market, provided it regains compliance with the Market Value of Listed Securities requirement by February 17, 2026. The extension, which follows an initial deficiency notice issued on May 5, 2025 and a prior grace period through November 3, 2025, temporarily halts any suspension of CASI’s securities while the company works to restore its market value above the $35 million threshold. The Panel’s decision took into account CASI’s recent strategic moves, including leadership changes, a renewed focus on executing development of CID-103, a convertible note financing, ongoing funding initiatives, and a planned divestiture of its China assets, signaling both operational restructuring and continued pressure to stabilize its financial and market position for investors and other stakeholders.

The most recent analyst rating on (CASI) stock is a Buy with a $4.00 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

CASI Pharmaceuticals Secures $20 Million for Renal AMR Study
Dec 11, 2025

On December 11, 2025, CASI Pharmaceuticals announced a $20 million convertible note financing agreement with ETP Global III Fund LP to support a Phase 1 study in China for renal allograft antibody-mediated rejection (AMR). This investment, structured in tranches, will also aid in developing a stable, high concentration protein solution for subcutaneous formulation, potentially enhancing CASI’s market position in biopharmaceuticals. The financing reflects strategic growth efforts, although it involves risks such as market volatility and operational challenges.

The most recent analyst rating on (CASI) stock is a Buy with a $4.00 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

CASI Pharmaceuticals Appoints James Huang as Non-Executive Chairman
Nov 19, 2025

On November 19, 2025, CASI Pharmaceuticals announced a significant change in its board governance with the appointment of James Huang as the Non-Executive Chairman of the Board, effective November 17, 2025. This move is part of a strategic effort to enhance governance and drive growth, as Dr. Wei-Wu He steps down from the Executive Chairman role but remains on the board. The appointment reflects confidence in Huang’s vision and leadership as the company advances its CID-103 development, particularly in addressing organ transplant rejection. This governance change is expected to align with shareholder interests and sustain the company’s long-term success.

The most recent analyst rating on (CASI) stock is a Hold with a $1.00 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

CASI Pharmaceuticals Reports Q3 2025 Results Amid Nasdaq Delisting Appeal
Nov 14, 2025

On November 14, 2025, CASI Pharmaceuticals announced its third-quarter 2025 business and financial results, highlighting ongoing advancements in its CID-103 clinical program. The company is preparing for a Phase 1 study in the U.S. for renal allograft antibody-mediated rejection (AMR) and is conducting a Phase 1 study for immune thrombocytopenia (ITP). Financially, CASI reported a 60% decrease in revenue to $3.1 million compared to the previous year, primarily due to changes in the distribution agreement for EVOMELA®. The company also faced a net loss increase to $10.9 million and received a Nasdaq delisting determination due to non-compliance with market value requirements, which it is appealing.

The most recent analyst rating on (CASI) stock is a Sell with a $1.50 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

CASI Pharmaceuticals Appeals Nasdaq Delisting Determination
Nov 10, 2025

CASI Pharmaceuticals announced that it received a delisting determination from Nasdaq due to its market value of listed securities falling below the minimum requirement for an extended period. The company has appealed the decision and is working on a compliance plan to maintain its Nasdaq listing, which is crucial for its operations and investor confidence.

The most recent analyst rating on (CASI) stock is a Sell with a $1.50 price target. To see the full list of analyst forecasts on CASI Pharmaceuticals stock, see the CASI Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 09, 2026