CalciMedica (CALC) AI Stock Analysis

• Market Cap: $83.29M
• Dividend Yield: N/A
• Average Volume (3M): 71.94K
• Price to Earnings (P/E): ―
• Beta (1Y): 0.32
• Revenue Growth: N/A
• EPS Growth: -2.46%
• Country: US
• Employees: 14
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.52
• Shares Outstanding: 14,409,431
• 10 Day Avg. Volume: 167,963
• 30 Day Avg. Volume: 71,939
• PEG Ratio: 0.03
• Price to Book (P/B): 2.76
• Price to Sales (P/S): 0.00
• P/FCF Ratio: -1.88
• Enterprise Value/Market Cap: 0.49
• Enterprise Value/Revenue: N/A
• Enterprise Value/Gross Profit: -2.94K
• Enterprise Value/Ebitda: -1.88
• 1Y Price Target: $20.00
• Price Target Upside: 275.23% Upside
• Rating Consensus: Moderate Buy
• Number of Analyst Covering: 1
• EPS Forecast (FY): -1.63
• Revenue Forecast (FY): N/A

• Rating: 51 Neutral
• Price Target: $6.00 ▲(12.57% Upside)

The score is held down primarily by weak financial fundamentals (no revenue, continued losses/cash burn, and a weakened balance sheet with negative equity and added debt). Technicals are a notable offset, showing strong upward momentum above key moving averages. Valuation is constrained by losses (negative P/E), while the expanded stock offering modestly improves funding flexibility but adds dilution risk.

Positive Factors

Product Development

The promising results from the Auxora trial indicate a significant therapeutic benefit, enhancing CalciMedica's competitive positioning in the biotech sector and potentially leading to future revenue streams.

Debt Reduction

Reducing debt levels improves financial stability and flexibility, allowing CalciMedica to focus resources on product development and strategic initiatives without the burden of debt servicing.

Stable Asset Base

A stable asset base provides a solid foundation for future growth and investment, supporting CalciMedica's long-term operational and strategic goals in the biotechnology sector.

Negative Factors

Zero Revenue

The absence of revenue reflects challenges in commercializing its biotechnology pipeline, which can hinder long-term growth and sustainability without successful product launches or partnerships.

Negative Cash Flow

Persistent negative cash flow indicates ongoing cash burn, typical for early-stage biotech firms, necessitating efficient cash management and potential additional financing to sustain operations.

Shrinking Equity

Diminishing equity affects financial stability and investor confidence, potentially limiting CalciMedica's ability to raise capital and invest in future growth opportunities.

CalciMedica Business Overview & Revenue Model

Company Description

CalciMedica, Inc., a clinical-stage biotechnology company, focuses on developing therapies for life-threatening inflammatory diseases with unmet needs. Its proprietary technology targets the inhibition of calcium release-activated (CRAC) channels designs to modulate the immune response and protect against tissue cell injury in life-threatening inflammatory diseases. Its lead product candidate is Auxora, a proprietary intravenous-formulated CRAC channel inhibitor for the treatment of acute pancreatitis, asparaginase-associated acute pancreatitis, and acute kidney injury. The company is based in La Jolla, California.

How the Company Makes Money

CalciMedica generates revenue primarily through the development and commercialization of its pharmaceutical products. The company may earn money through partnerships, collaborations, and licensing agreements with other pharmaceutical and biotechnology companies. These arrangements often involve upfront payments, milestone payments, and royalties on sales. Additionally, CalciMedica may receive funding from government grants or research institutions to support its clinical trials and drug development programs. The success of its lead product candidate, Auxora, in clinical trials and its eventual approval and commercialization would be a significant source of revenue for the company.

CalciMedica Financial Statement Overview

Summary

CalciMedica faces significant financial challenges, primarily due to the absence of revenue and persistent operational losses. The reduction in debt and consistent asset base are positive signs, but the shrinking equity and negative cash flows highlight the need for strategic financial and operational improvements.

Income Statement

CalciMedica has consistently reported zero revenue over the years, reflecting challenges in commercializing its biotechnology pipeline. Despite some reduction in net losses, the company continues to operate with substantial negative EBIT and EBITDA margins, indicating persistent operational inefficiencies.

Balance Sheet

The balance sheet shows a positive trend in reducing debt, with the company having zero total debt in recent years. However, the equity has significantly diminished from 2019 to 2024, impacting the equity ratio negatively. The company maintains a stable asset base, which is positive, but the shrinking equity indicates potential financial instability.

Cash Flow

Free cash flow remains negative, and the operating cash flow is consistently negative as well, reflecting cash burn typical for early-stage biotech firms. Despite improvements in free cash flow growth from 2023 to 2024, the overall cash flow position highlights the need for efficient cash management and potential additional financing.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	0.00	0.00	0.00	0.00	0.00	0.00
Gross Profit	-14.00K	0.00	0.00	0.00	-519.00K	-395.00K
EBITDA	-21.92M	-24.15M	-38.02M	-7.64M	-35.30M	-27.14M
Net Income	-23.06M	-13.70M	-34.36M	-7.82M	-35.82M	-27.53M
Balance Sheet
Total Assets	14.91M	19.79M	12.19M	3.35M	69.09M	101.79M
Cash, Cash Equivalents and Short-Term Investments	14.08M	18.67M	11.24M	1.33M	63.67M	95.03M
Total Debt	8.90M	0.00	0.00	5.36M	0.00	0.00
Total Liabilities	15.18M	5.38M	4.03M	12.58M	4.07M	7.01M
Stockholders Equity	-268.00K	14.41M	8.16M	-9.23M	65.02M	94.79M
Cash Flow
Free Cash Flow	-21.32M	-21.15M	-25.81M	-11.76M	-31.99M	-33.09M
Operating Cash Flow	-21.30M	-21.15M	-25.73M	-11.76M	-31.50M	-32.06M
Investing Cash Flow	-2.76M	-4.42M	8.88M	-4.00K	10.75M	-42.56M
Financing Cash Flow	20.38M	27.97M	20.90M	8.48M	695.00K	92.17M

CalciMedica Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 5.33
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Positive

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CALC, the sentiment is Neutral. The current price of 5.33 is below the 20-day moving average (MA) of 5.61, above the 50-day MA of 4.38, and above the 200-day MA of 2.90, indicating a neutral trend. The MACD of 0.43 indicates Positive momentum. The RSI at 50.01 is Neutral, neither overbought nor oversold. The STOCH value of 8.39 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for CALC.

CalciMedica Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
LTRN	52 Neutral	$38.14M	―	-104.58%	―	―	1.18%
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
CALC	51 Neutral	$83.29M	-3.32	-526.36%	―	―	-2.46%
FGEN	51 Neutral	$39.28M	0.23	―	―	-95.39%	―
PDSB	51 Neutral	$52.15M	―	-221.81%	―	―	29.95%
SKYE	48 Neutral	$35.58M	-0.81	-94.31%	―	―	-53.18%
SNTI	48 Neutral	$30.23M	-0.32	-394.62%	―	―	78.60%

CalciMedica Corporate Events

CalciMedica Boosts Stock Offering to $9.7 Million

On November 6, 2025, CalciMedica, Inc. announced an increase in the maximum aggregate offering price of its common stock from $4,450,000 to $9,700,000 under its at-the-market offering agreement with H.C. Wainwright & Co. This adjustment reflects the company’s strategic move to bolster its financial resources, potentially enhancing its market position and providing greater flexibility in pursuing its operational goals.

The most recent analyst rating on (CALC) stock is a Buy with a $16.00 price target. To see the full list of analyst forecasts on CalciMedica stock, see the CALC Stock Forecast page.