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Aytu BioScience Inc (AYTU)
NASDAQ:AYTU
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Aytu BioScience (AYTU) AI Stock Analysis

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AYTU

Aytu BioScience

(NASDAQ:AYTU)

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Neutral 50 (OpenAI - 4o)
Rating:50Neutral
Price Target:
$2.00
▼(-1.48% Downside)
Aytu BioScience's overall score reflects significant financial challenges and a cautious valuation. However, the upcoming ExuA launch and positive adjusted EBITDA provide some optimism. Technical indicators suggest potential downward pressure, warranting careful monitoring.
Positive Factors
ExuA Launch
The launch of ExuA, targeting a $22 billion market, could significantly enhance Aytu's market position and address unmet needs in MDD treatment.
Positive Adjusted EBITDA
Consistent positive adjusted EBITDA reflects operational efficiency and financial discipline, supporting long-term business sustainability.
Pediatric Portfolio Growth
Growth in the pediatric portfolio indicates successful execution of growth strategies and potential for further market expansion.
Negative Factors
Decline in Gross Margin
A declining gross margin can pressure profitability, highlighting the need for cost management and operational efficiency improvements.
ADHD Portfolio Stability Concerns
Flat revenue and potential generic competition in the ADHD portfolio could limit growth and impact competitive positioning.
Impairment Expense Impact
Impairment expenses indicate asset write-downs, impacting financial health and signaling potential strategic shifts or challenges.

Aytu BioScience (AYTU) vs. SPDR S&P 500 ETF (SPY)

Aytu BioScience Business Overview & Revenue Model

Company DescriptionAytu Biopharma, Inc., a specialty pharmaceutical company, focuses on developing and commercializing novel therapeutics and consumer healthcare products the United States and internationally. The company offers Adzenys XR-ODT for the treatment of attention deficit hyperactivity disorder (ADHD) in patients from 6 years and older; Cotempla XR-ODT for the treatment of ADHD in patients from 6 to 17 years old; and Adzenys ER, an oral suspension for the treatment of ADHD in patients from 6 years and older. It also provides Karbinal ER, a carbinoxamine oral suspension for the treatment of seasonal and perennial allergies; Poly-Vi-Flor and Tri-Vi-Flor prescription supplements for infants and children for the treatment of fluoride deficiency; Tuzistra XR, a prescription antitussive consisting of codeine polistirex and chlorpheniramine polistirex in an oral suspension; and ZolpiMist, an oral spray for the treatment of insomnia. The company was formerly known as Aytu BioScience, Inc. and changed its name to Aytu Biopharma, Inc. in March 2021. Aytu Biopharma, Inc. was incorporated in 2015 and is headquartered in Englewood, Colorado.
How the Company Makes MoneyAytu BioScience generates revenue through the sale of its pharmaceutical products and diagnostic tests. The company has a diversified revenue model that includes direct sales of its proprietary products, as well as partnerships with other pharmaceutical companies for co-promotion and distribution. Key revenue streams are derived from product sales in the urology and pediatric markets, where Aytu has established a presence. Additionally, the company may benefit from licensing agreements, collaborations, and research grants that contribute to its financial performance. Strategic partnerships with healthcare providers and institutions also play a crucial role in expanding its market reach and enhancing sales.

Aytu BioScience Key Performance Indicators (KPIs)

Any
Any
Revenue by Product
Revenue by Product
Chart Insights
Data provided by:Main Street Data

Aytu BioScience Earnings Call Summary

Earnings Call Date:Sep 23, 2025
(Q4-2025)
|
% Change Since: |
Next Earnings Date:Nov 13, 2025
Earnings Call Sentiment Neutral
The call highlighted significant enthusiasm around the upcoming launch of ExuA and positive financial metrics like the third consecutive year of positive adjusted EBITDA. However, challenges such as a decline in gross margin and potential competition in the ADHD portfolio present concerns.
Q4-2025 Updates
Positive Updates
ExuA Launch Plans
Aytu BioPharma has announced the upcoming launch of ExuA, a novel first-in-class treatment for major depressive disorder (MDD), expected to significantly transform the company.
Positive Adjusted EBITDA
The company reported a positive adjusted EBITDA for the third consecutive year, reaching $9.2 million for fiscal 2025.
Pediatric Portfolio Growth
The pediatric portfolio showed growth, with net revenue increasing from $7.3 million to $8.8 million, reflecting the positive effect of the company's return to growth plan.
Successful Financing
Aytu BioPharma completed a successful at-the-market public offering, raising $16.6 million gross and just under $15 million net, led by healthcare-focused institutional investors.
Negative Updates
Decline in Gross Margin
Gross margin decreased from 75% to 69% due to increased cost of sales in the ADHD inventory, related to overhead costs from the closed manufacturing facility.
ADHD Portfolio Stability Concerns
ADHD portfolio net revenue remained relatively flat at $57.6 million compared to $57.8 million, with concerns about the impact of potential generic competition.
Impairment Expense Impact
An $8.3 million impairment expense was recorded on the pediatric portfolio due to a shifted focus to ExuA and the ADHD portfolio.
Company Guidance
During the Aytu BioPharma, Inc. fiscal 2025 call, guidance was provided highlighting key financial metrics and strategic initiatives. For fiscal year 2025, the company reported net revenue of $66.4 million, a slight increase compared to the previous year, and achieved its third consecutive year of positive adjusted EBITDA at $9.2 million. The company emphasized the upcoming launch of ExuA, an FDA-approved novel treatment for major depressive disorder, expected to significantly impact Aytu’s market position within the $22 billion U.S. market. ExuA, distinct due to its 5-HT1A receptor agonist mechanism, is anticipated to address unmet needs in the MDD market by minimizing sexual dysfunction and weight gain side effects common to SSRIs and SNRIs. Aytu's strategic focus includes leveraging its Aytu RxConnect platform for efficient market penetration and is preparing for ExuA’s commercial launch by the end of 2025. The company also highlighted its plans to optimize gross margins, particularly through improved ADHD product packaging and cost structures. Additionally, Aytu plans to invest approximately $10 million in launching ExuA in fiscal 2026, with expectations to ramp up commercial operations significantly in the subsequent quarters.

Aytu BioScience Financial Statement Overview

Summary
Aytu BioScience faces significant financial challenges, with declining revenues and persistent losses impacting profitability. Despite a strong gross profit margin, the negative net profit margin and cash flow issues highlight the need for strategic improvements.
Income Statement
Aytu BioScience's income statement reveals challenges with profitability and revenue growth. The company has experienced a decline in revenue over the past year, with a negative revenue growth rate of -4.10%. Gross profit margin remains relatively strong at 69.04%, indicating efficient production, but the net profit margin is negative at -20.43%, reflecting ongoing losses. EBIT and EBITDA margins are also negative, highlighting operational inefficiencies.
Balance Sheet
The balance sheet shows a moderate debt-to-equity ratio of 0.10, suggesting manageable leverage. However, the return on equity is significantly negative at -71.51%, indicating poor returns for shareholders. The equity ratio stands at 15.27%, showing a reasonable proportion of equity financing relative to total assets.
Cash Flow
Cash flow analysis indicates a concerning decline in free cash flow growth at -62.28%. The operating cash flow to net income ratio is negative, reflecting cash flow challenges. However, the free cash flow to net income ratio is positive at 1.12, suggesting that free cash flow covers net losses, albeit with limited margin.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue66.38M66.38M81.00M107.40M96.67M65.63M
Gross Profit45.83M45.83M49.37M66.63M46.44M29.20M
EBITDA5.13M-4.67M-1.01M-3.27M-98.74M-29.04M
Net Income-13.56M-13.56M-15.84M-17.05M-108.78M-58.29M
Balance Sheet
Total Assets124.43M124.18M118.09M136.46M137.62M265.67M
Cash, Cash Equivalents and Short-Term Investments30.95M30.95M20.01M22.98M19.36M49.65M
Total Debt22.94M1.86M16.42M18.45M18.19M28.35M
Total Liabilities105.46M105.21M90.38M97.11M93.31M128.10M
Stockholders Equity18.97M18.97M27.72M39.36M44.31M137.57M
Cash Flow
Free Cash Flow-5.17M-2.17M-1.39M-5.13M-28.82M-28.30M
Operating Cash Flow-1.94M-1.94M-1.39M-5.13M-28.82M-25.96M
Investing Cash Flow-2.56M-2.56M-329.00K-117.00K-3.25M-2.78M
Financing Cash Flow15.44M15.44M-1.26M8.87M1.53M30.31M

Aytu BioScience Technical Analysis

Technical Analysis Sentiment
Negative
Last Price2.03
Price Trends
50DMA
2.23
Negative
100DMA
2.27
Negative
200DMA
1.85
Positive
Market Momentum
MACD
-0.03
Positive
RSI
38.74
Neutral
STOCH
46.98
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AYTU, the sentiment is Negative. The current price of 2.03 is below the 20-day moving average (MA) of 2.25, below the 50-day MA of 2.23, and above the 200-day MA of 1.85, indicating a neutral trend. The MACD of -0.03 indicates Positive momentum. The RSI at 38.74 is Neutral, neither overbought nor oversold. The STOCH value of 46.98 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for AYTU.

Aytu BioScience Risk Analysis

Aytu BioScience disclosed 59 risk factors in its most recent earnings report. Aytu BioScience reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Aytu BioScience Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$21.11M-0.76-60.76%-18.05%33.87%
47
Neutral
$13.54M-29.32-1.98%156.93%92.75%
41
Neutral
$20.93M-0.68-52.69%
38
Underperform
$6.77M-0.23-230.73%-22.60%53.82%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AYTU
Aytu BioScience
2.03
0.39
23.78%
TXMD
TherapeuticsMD
1.39
-0.13
-8.55%
COSM
Cosmos Holdings
0.69
<0.01
1.47%
FLGC
Flora Growth
8.06
-41.47
-83.73%
GELS
Gelteq Limited
1.02
-1.30
-56.03%

Aytu BioScience Corporate Events

Aytu BioPharma’s Optimistic Earnings Call Highlights ExuA Launch
Sep 25, 2025

Aytu BioPharma’s recent earnings call was marked by a sense of optimism and strategic focus. The company expressed significant enthusiasm about the upcoming launch of ExuA, a novel treatment for major depressive disorder, and celebrated its third consecutive year of positive adjusted EBITDA. However, the call also acknowledged challenges such as a decline in gross margin and potential competition in the ADHD portfolio, which could pose hurdles moving forward.

Aytu BioPharma Reports Fiscal 2025 Earnings and EXXUA Launch Plans
Sep 24, 2025

Aytu BioPharma, Inc. is a pharmaceutical company dedicated to developing innovative treatments for complex central nervous system diseases, with a focus on improving patient quality of life. The company offers prescription products for conditions such as major depressive disorder and ADHD.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 08, 2025