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PYC Therapeutics Limited (AU:PYC)
:PYC
Australian Market
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PYC Therapeutics Limited (PYC) AI Stock Analysis

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AU

PYC Therapeutics Limited

(Sydney:PYC)

Rating:54Neutral
Price Target:
AU$1.50
▲(10.29%Upside)
PYC Therapeutics receives a moderate score due to strong revenue growth but is heavily impacted by ongoing profitability and cash flow challenges. The stock shows positive technical momentum, although this is countered by overbought signals. Valuation metrics are unfavorable due to negative earnings and lack of dividends.
Positive Factors
Acquisition Validation
NVS Acquisition of RGLS further validates the mechanism of action for potentially best-in-class PYC-003.
Analyst Rating
Bloom Burton is initiating research coverage of genetic medicine company, PYC Therapeutics, with a BUY rating (Speculative risk).
Clinical Trials
PYC-003 is now being assessed in a Phase I in healthy volunteers, entering a catalyst-rich period across all of its clinical programs.
Negative Factors
Probability Adjustment
Applying a 15% probability to the CVR, increases the valuation to AU$2.70 (US$1.72).
Valuation Concerns
The upfront payment of US$7.00 per share infers an EV of US$0.8B – if applied to PYC’s capital structure, this generates a PYC valuation of AU$2.35 per share (US$1.50).

PYC Therapeutics Limited (PYC) vs. iShares MSCI Australia ETF (EWA)

PYC Therapeutics Limited Business Overview & Revenue Model

Company DescriptionPYC Therapeutics Limited (PYC) is a biotechnology company focused on the development of innovative therapies for the treatment of genetic diseases. The company operates in the biopharmaceutical sector, leveraging its proprietary drug delivery platforms to create precision medicines. PYC's core products include RNA-based therapeutics designed to target and correct genetic mutations at their source, offering potential treatments for a range of inherited disorders.
How the Company Makes MoneyPYC Therapeutics Limited generates revenue primarily through the development and commercialization of its proprietary RNA-based therapeutic candidates. The company's revenue streams may include upfront payments, milestone payments, and royalties from partnerships or licensing agreements with larger pharmaceutical companies. These collaborations enable PYC to leverage the resources and expertise of established firms to advance its drug candidates through the clinical trial process and eventually to market. Additionally, PYC may receive research and development grants or funding from governmental or private entities to support its ongoing projects. The company's ability to secure strategic partnerships and successfully bring its therapies to market are significant factors contributing to its earnings.

PYC Therapeutics Limited Financial Statement Overview

Summary
PYC Therapeutics shows strong revenue growth, but faces ongoing profitability and cash flow challenges, with negative free cash flow and net losses. The balance sheet is strong with minimal debt, offering financial stability, yet operational efficiency improvements are needed.
Income Statement
45
Neutral
PYC Therapeutics has shown a significant increase in revenue over the recent years, with a revenue growth rate of 39.58% from 2023 to 2024. However, the company continues to operate at a loss, with negative net profit and EBIT margins indicating ongoing profitability challenges. The consistent operating losses highlight the need for cost management and operational efficiency improvements.
Balance Sheet
60
Neutral
The company's balance sheet shows a solid equity base with an equity ratio of 88.23%, suggesting low leverage and financial stability. However, the debt-to-equity ratio is low at 0.01, indicating conservative use of debt, which might limit growth funding options. The return on equity remains negative due to net losses, impacting investor returns.
Cash Flow
50
Neutral
PYC Therapeutics has a concerning trend of negative free cash flow, worsening from 2023 to 2024. The operating cash flow to net income ratio is negative, reflecting challenges in generating cash from operations. Despite significant financing cash inflows, the reliance on external funding raises sustainability concerns.
BreakdownJun 2024Jun 2023Jun 2022Jun 2021Jun 2020
Income Statement
Total Revenue22.06M15.81M16.04M3.07M2.40M
Gross Profit22.06M14.92M15.20M2.45M1.85M
EBITDA-38.12M-38.25M-29.39M-21.04M-8.89M
Net Income-37.73M-22.79M-13.86M-17.77M-6.82M
Balance Sheet
Total Assets91.24M37.17M45.35M57.94M31.55M
Cash, Cash Equivalents and Short-Term Investments66.87M15.57M29.11M51.50M25.43M
Total Debt1.11M315.49K943.77K730.35K798.14K
Total Liabilities10.18M8.72M5.15M4.02M1.35M
Stockholders Equity80.50M27.75M39.35M53.04M28.45M
Cash Flow
Free Cash Flow-38.90M-24.91M-22.17M-12.38M-5.85M
Operating Cash Flow-38.59M-24.42M-21.78M-11.79M-5.75M
Investing Cash Flow-307.04K-477.12K32.68M-15.52M-13.77M
Financing Cash Flow90.19M11.44M-182.36K38.56M25.11M

PYC Therapeutics Limited Technical Analysis

Technical Analysis Sentiment
Positive
Last Price1.36
Price Trends
50DMA
1.26
Positive
100DMA
1.22
Positive
200DMA
1.39
Negative
Market Momentum
MACD
0.05
Positive
RSI
57.19
Neutral
STOCH
41.58
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:PYC, the sentiment is Positive. The current price of 1.36 is above the 20-day moving average (MA) of 1.33, above the 50-day MA of 1.26, and below the 200-day MA of 1.39, indicating a neutral trend. The MACD of 0.05 indicates Positive momentum. The RSI at 57.19 is Neutral, neither overbought nor oversold. The STOCH value of 41.58 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for AU:PYC.

PYC Therapeutics Limited Peers Comparison

Overall Rating
UnderperformOutperform
Sector (50)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
AUCUV
77
Outperform
$544.34M14.3919.93%0.46%12.74%27.56%
AUPYC
54
Neutral
AU$793.23M-112.97%-84.82%
AUCU6
53
Neutral
AU$1.10B-53.99%-40.19%
AUBOT
53
Neutral
AU$294.17M-56.99%10.76%-195.89%
AUIMM
50
Neutral
$365.10M-31.16%14.47%
50
Neutral
AU$2.51B3.43-57.47%2.67%36.73%13.67%
AUOPT
30
Underperform
$738.77M
-24.46%-7.90%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AU:PYC
PYC Therapeutics Limited
1.36
0.27
24.77%
AU:OPT
Opthea
0.60
0.22
57.89%
AU:CUV
Clinuvel Pharmaceuticals
11.14
-4.34
-28.03%
AU:IMM
Immutep Ltd
0.26
-0.03
-11.86%
AU:CU6
Clarity Pharmaceuticals Ltd.
3.48
-2.80
-44.59%
AU:BOT
Botanix Pharmaceuticals Limited
0.16
-0.21
-56.76%

PYC Therapeutics Limited Corporate Events

PYC Therapeutics Advances Clinical Trials for PKD Treatment
Jul 7, 2025

PYC Therapeutics has announced the progression of its clinical trials for PYC-003, a drug candidate targeting Polycystic Kidney Disease (PKD). Following approval from the Safety Review Committee, the company will advance to Part B of the Single Ascending Dose study and escalate dosing in Part A. This milestone allows PYC to commence patient dosing and aligns with their timeline to initiate repeat dose studies by Q4 2025, marking significant progress in their efforts to address PKD.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Advances Phelan-McDermid Syndrome Program
Jun 27, 2025

PYC Therapeutics announced progress in its Phelan-McDermid Syndrome (PMS) program, presenting data at the PMS Global Congress in Barcelona. The data shows that their drug candidate, PYC-002, restores missing gene expression and rescues functional deficits in neurons, addressing the underlying cause of PMS. This advancement is significant as there are currently no approved treatments for PMS, and the program is expected to enter clinical trials in about 12 months, marking the company’s fourth first-in-class drug candidate with disease-modifying potential.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Advances VP-001 with FDA Trial Design Approval
Jun 23, 2025

PYC Therapeutics has received FDA alignment on the design of its registrational trial for VP-001, a drug candidate aimed at treating Retinitis Pigmentosa type 11 (RP11), a blinding eye disease. The FDA’s acceptance of PYC’s trial design, including the use of a sham control arm and specific inclusion criteria, marks a significant step towards a New Drug Application. This progress could enhance PYC’s positioning in the biotechnology industry by advancing its clinical pipeline and potentially offering a new treatment option for RP11 patients.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Advances ADOA Clinical Trial with Dose Escalation Approval
Jun 11, 2025

PYC Therapeutics has received approval from the Safety Review Committee to escalate the dose of its investigational drug candidate, PYC-001, in its clinical trial for Autosomal Dominant Optic Atrophy (ADOA). This approval allows the company to move from cohort 2 to cohort 3, increasing the dose from 10 to 30 micrograms per eye. The progression of this trial is a significant step towards establishing the safety and efficacy of PYC-001, with plans for further studies and a potential Phase 2/3 trial to support a New Drug Application.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Updates Investors in Q2 Webinar
May 30, 2025

PYC Therapeutics Limited recently held a Q2 investor webinar to update stakeholders on its business activities. The presentation emphasized the company’s ongoing commitment to advancing its scientific endeavors, though it cautioned that the information provided should be considered in conjunction with past and future announcements. The company highlighted the inherent risks and uncertainties in its forward-looking statements, urging stakeholders to exercise caution when interpreting the information.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Advances Clinical Trial for PKD Treatment
May 26, 2025

PYC Therapeutics Limited has received approval to escalate dosing in its clinical trial for PYC-003, a drug candidate for Polycystic Kidney Disease (PKD). The Safety Review Committee has approved the increase in dosage for the second cohort of healthy volunteers, with plans to initiate dosing in PKD patients upon successful review of safety data. This progression marks a significant step in PYC’s clinical trial process, potentially leading to a Phase 2/3 trial aimed at supporting a New Drug Application for PYC-003.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Announces Cessation of Securities
May 23, 2025

PYC Therapeutics Limited announced the cessation of certain securities due to unmet conditions, affecting options expiring in 2026, 2027, and 2028. This announcement may impact the company’s capital structure and investor relations, as it reflects on the company’s strategic decisions regarding its financial instruments.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Announces Investor Webinar and Updates on Drug Development Progress
May 13, 2025

PYC Therapeutics Limited has announced an investor webinar scheduled for May 30, 2025, to update shareholders on its progress in Q2 2025. The company is advancing several drug development programs, including treatments for Retinitis Pigmentosa type 11, Autosomal Dominant Optic Atrophy, Autosomal Dominant Polycystic Kidney Disease, and Phelan McDermid Syndrome. These programs are at various stages of clinical trials, with significant milestones anticipated in 2025 and 2026, potentially impacting the company’s market position and stakeholder interests.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Unveils Promising Trial Results for Retinitis Pigmentosa Treatment
May 1, 2025

PYC Therapeutics Limited announced the results of its Phase 1/2 clinical trials for Retinitis Pigmentosa type 11, a blinding eye disease, at the Foundation Fighting Blindness Retinal Therapeutics Innovation Summit. This development marks a significant step in PYC’s efforts to provide treatment options for genetic diseases with no current therapies, potentially enhancing its position in the RNA therapeutics market.

PYC Therapeutics Announces Change in Substantial Shareholder Interests
Apr 28, 2025

PYC Therapeutics Limited has announced a change in the interests of a substantial holder, Australian Land Pty Ltd, and other entities associated with Mr. Alan Tribe. The change, effective from April 23, 2025, reflects a shift in voting power due to a series of entitlement offers and share consolidations. This adjustment in shareholding structure may impact the company’s governance dynamics and influence future strategic decisions.

PYC Therapeutics Reports Positive Clinical Trial Results for Eye Disease Treatment
Apr 28, 2025

PYC Therapeutics announced promising results from Phase 1/2 clinical trials of its drug candidate VP-001, aimed at treating Retinitis Pigmentosa type 11. The data, to be presented at upcoming international conferences, shows significant improvements in vision and quality of life for patients, with the drug being safe and well-tolerated. This positions PYC’s platform technology as a valuable tool in addressing blinding eye diseases, with plans to discuss a New Drug Application pathway with the FDA in June 2025.

PYC Therapeutics Advances Towards Commercial Stage with Extended Funding
Apr 23, 2025

PYC Therapeutics has made significant progress in Q1 2025 towards becoming a commercial-stage drug developer, extending its cash runway to over $200 million through a $146 million Entitlement Offer. This funding supports the advancement of its drug candidates, including human trials for polycystic kidney disease and ongoing studies in Retinitis Pigmentosa, positioning the company for improved market conditions and stakeholder confidence.

PYC Therapeutics Announces Quotation of New Securities on ASX
Apr 23, 2025

PYC Therapeutics Limited has announced the application for the quotation of 32,313,759 ordinary fully paid securities on the Australian Securities Exchange (ASX), with the issue date set for April 24, 2025. This move is part of previously announced transactions and is expected to enhance the company’s financial flexibility, potentially impacting its market positioning and providing opportunities for stakeholders.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 08, 2025