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PYC Therapeutics Limited (AU:PYC)
ASX:PYC
Australian Market

PYC Therapeutics Limited (PYC) AI Stock Analysis

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AU

PYC Therapeutics Limited

(Sydney:PYC)

Rating:50Neutral
Price Target:
AU$1.00
▼(-21.88%Downside)
PYC Therapeutics demonstrates strong revenue growth and financial stability due to a solid balance sheet and low debt. However, persistent profitability issues, negative cash flows, and a challenging valuation due to a negative P/E ratio weigh heavily on the score. The technical analysis indicates a neutral market momentum, neither encouraging nor discouraging potential investors significantly.
Positive Factors
Analyst Coverage and Ratings
Bloom Burton is initiating research coverage of genetic medicine company, PYC Therapeutics, with a BUY rating (Speculative risk).
Clinical Program Advancements
PYC-003 is now being assessed in a Phase I in healthy volunteers, entering a catalyst-rich period across all of its clinical programs.
Validation and Partnerships
NVS Acquisition of RGLS further validates MOA for potentially best-in-class PYC-003.
Negative Factors
Probability and Risk Assessment
Applying a 15% probability to the CVR, increases the valuation to AU$2.70 (US$1.72).
Valuation Concerns
The upfront payment of US$7.00 per share infers an EV of US$0.8B – if applied to PYC’s capital structure, this generates a PYC valuation of AU$2.35 per share (US$1.50).

PYC Therapeutics Limited (PYC) vs. iShares MSCI Australia ETF (EWA)

PYC Therapeutics Limited Business Overview & Revenue Model

Company DescriptionPYC Therapeutics Limited, a drug-development company, engages in the discovery and development of drug solutions in the areas of ribonucleic acid therapeutics in Australia. The company's preclinical development programs include VP-001, drug program for retinitis pigmentosa type 11; and PYC-001, a drug program for the treatment of autosomal dominant optic atrophy. It also focuses on the development of programs for kidney, retinal, and central nervous system diseases. PYC Therapeutics Limited has academic-industry collaborations with Murdoch University to support drug discovery and development efforts in the field of neurodegenerative disorders, including Motor Neurone Disease. The company was formerly known as Phylogica Limited and changed its name to PYC Therapeutics Limited in November 2019. PYC Therapeutics Limited was incorporated in 2001 and is based in Nedlands, Australia.
How the Company Makes MoneyPYC Therapeutics Limited generates revenue primarily through the development and commercialization of its RNA-based therapeutic products. The company may engage in partnerships and collaborations with other pharmaceutical companies to co-develop or out-license its drug candidates, which can provide milestone payments and royalties if the products reach the market. Additionally, PYC could secure funding through grants, research contracts, and strategic alliances, which contribute to its financial resources for continued research and development. The firm's earnings are heavily reliant on the successful advancement of its drug pipeline and the approval of its therapies by regulatory authorities.

PYC Therapeutics Limited Financial Statement Overview

Summary
PYC Therapeutics shows strong revenue growth but faces persistent profitability and cash flow challenges. The balance sheet is strong with minimal debt, providing financial stability. However, the company needs to improve operational efficiency and manage cash flows better to ensure long-term sustainability.
Income Statement
45
Neutral
PYC Therapeutics has shown a significant increase in revenue over the recent years, with a revenue growth rate of 39.58% from 2023 to 2024. However, the company continues to operate at a loss, with negative net profit and EBIT margins indicating ongoing profitability challenges. The consistent operating losses highlight the need for cost management and operational efficiency improvements.
Balance Sheet
60
Neutral
The company's balance sheet shows a solid equity base with an equity ratio of 88.23%, suggesting low leverage and financial stability. However, the debt-to-equity ratio is low at 0.01, indicating conservative use of debt, which might limit growth funding options. The return on equity remains negative due to net losses, impacting investor returns.
Cash Flow
50
Neutral
PYC Therapeutics has a concerning trend of negative free cash flow, worsening from 2023 to 2024. The operating cash flow to net income ratio is negative, reflecting challenges in generating cash from operations. Despite significant financing cash inflows, the reliance on external funding raises sustainability concerns.
BreakdownTTMJun 2024Jun 2023Jun 2022Jun 2021Jun 2020
Income Statement
Total Revenue24.99M22.06M15.81M16.04M3.07M2.40M
Gross Profit24.99M22.06M14.92M15.20M2.45M1.85M
EBITDA-49.42M-38.12M-38.25M-29.39M-21.04M-8.89M
Net Income-48.20M-37.73M-22.79M-13.86M-17.77M-6.82M
Balance Sheet
Total Assets68.23M91.24M37.17M45.35M57.94M31.55M
Cash, Cash Equivalents and Short-Term Investments49.25M66.87M15.57M29.11M51.50M25.43M
Total Debt1.21M1.11M315.49K943.77K730.35K798.14K
Total Liabilities12.52M10.18M8.72M5.15M4.02M1.35M
Stockholders Equity55.44M80.50M27.75M39.35M53.04M28.45M
Cash Flow
Free Cash Flow-49.55M-38.90M-24.91M-22.17M-12.38M-5.85M
Operating Cash Flow-48.77M-38.59M-24.42M-21.78M-11.79M-5.75M
Investing Cash Flow-780.06K-307.04K-477.12K32.68M-15.52M-13.77M
Financing Cash Flow72.76M90.19M11.44M-182.36K38.56M25.11M

PYC Therapeutics Limited Technical Analysis

Technical Analysis Sentiment
Positive
Last Price1.28
Price Trends
50DMA
1.19
Positive
100DMA
1.20
Positive
200DMA
1.40
Negative
Market Momentum
MACD
<0.01
Negative
RSI
59.48
Neutral
STOCH
94.29
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:PYC, the sentiment is Positive. The current price of 1.28 is above the 20-day moving average (MA) of 1.20, above the 50-day MA of 1.19, and below the 200-day MA of 1.40, indicating a neutral trend. The MACD of <0.01 indicates Negative momentum. The RSI at 59.48 is Neutral, neither overbought nor oversold. The STOCH value of 94.29 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for AU:PYC.

PYC Therapeutics Limited Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.39B0.31-61.07%2.34%17.46%1.71%
AUPYC
50
Neutral
AU$749.49M-112.97%-84.82%
$484.35M
$329.19M14.1419.93%0.44%
$228.59M-31.16%
AUCU6
53
Neutral
AU$671.88M-53.99%-40.19%
AUBOT
53
Neutral
AU$568.65M-56.99%10.76%-195.89%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AU:PYC
PYC Therapeutics Limited
1.26
0.07
5.88%
CKDXF
Opthea Limited
0.48
0.19
65.52%
CLVLF
Clinuvel Pharmaceuticals
7.22
-3.04
-29.63%
PRRUF
Immutep Ltd
0.19
0.01
5.56%
AU:CU6
Clarity Pharmaceuticals Ltd.
2.39
-3.03
-55.90%
AU:BOT
Botanix Pharmaceuticals Limited
0.32
-0.02
-5.88%

PYC Therapeutics Limited Corporate Events

PYC Therapeutics Advances VP-001 with FDA Trial Design Approval
Jun 23, 2025

PYC Therapeutics has received FDA alignment on the design of its registrational trial for VP-001, a drug candidate aimed at treating Retinitis Pigmentosa type 11 (RP11), a blinding eye disease. The FDA’s acceptance of PYC’s trial design, including the use of a sham control arm and specific inclusion criteria, marks a significant step towards a New Drug Application. This progress could enhance PYC’s positioning in the biotechnology industry by advancing its clinical pipeline and potentially offering a new treatment option for RP11 patients.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Advances ADOA Clinical Trial with Dose Escalation Approval
Jun 11, 2025

PYC Therapeutics has received approval from the Safety Review Committee to escalate the dose of its investigational drug candidate, PYC-001, in its clinical trial for Autosomal Dominant Optic Atrophy (ADOA). This approval allows the company to move from cohort 2 to cohort 3, increasing the dose from 10 to 30 micrograms per eye. The progression of this trial is a significant step towards establishing the safety and efficacy of PYC-001, with plans for further studies and a potential Phase 2/3 trial to support a New Drug Application.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Updates Investors in Q2 Webinar
May 30, 2025

PYC Therapeutics Limited recently held a Q2 investor webinar to update stakeholders on its business activities. The presentation emphasized the company’s ongoing commitment to advancing its scientific endeavors, though it cautioned that the information provided should be considered in conjunction with past and future announcements. The company highlighted the inherent risks and uncertainties in its forward-looking statements, urging stakeholders to exercise caution when interpreting the information.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Advances Clinical Trial for PKD Treatment
May 26, 2025

PYC Therapeutics Limited has received approval to escalate dosing in its clinical trial for PYC-003, a drug candidate for Polycystic Kidney Disease (PKD). The Safety Review Committee has approved the increase in dosage for the second cohort of healthy volunteers, with plans to initiate dosing in PKD patients upon successful review of safety data. This progression marks a significant step in PYC’s clinical trial process, potentially leading to a Phase 2/3 trial aimed at supporting a New Drug Application for PYC-003.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Announces Cessation of Securities
May 23, 2025

PYC Therapeutics Limited announced the cessation of certain securities due to unmet conditions, affecting options expiring in 2026, 2027, and 2028. This announcement may impact the company’s capital structure and investor relations, as it reflects on the company’s strategic decisions regarding its financial instruments.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Announces Investor Webinar and Updates on Drug Development Progress
May 13, 2025

PYC Therapeutics Limited has announced an investor webinar scheduled for May 30, 2025, to update shareholders on its progress in Q2 2025. The company is advancing several drug development programs, including treatments for Retinitis Pigmentosa type 11, Autosomal Dominant Optic Atrophy, Autosomal Dominant Polycystic Kidney Disease, and Phelan McDermid Syndrome. These programs are at various stages of clinical trials, with significant milestones anticipated in 2025 and 2026, potentially impacting the company’s market position and stakeholder interests.

The most recent analyst rating on (AU:PYC) stock is a Buy with a A$4.00 price target. To see the full list of analyst forecasts on PYC Therapeutics Limited stock, see the AU:PYC Stock Forecast page.

PYC Therapeutics Unveils Promising Trial Results for Retinitis Pigmentosa Treatment
May 1, 2025

PYC Therapeutics Limited announced the results of its Phase 1/2 clinical trials for Retinitis Pigmentosa type 11, a blinding eye disease, at the Foundation Fighting Blindness Retinal Therapeutics Innovation Summit. This development marks a significant step in PYC’s efforts to provide treatment options for genetic diseases with no current therapies, potentially enhancing its position in the RNA therapeutics market.

PYC Therapeutics Announces Change in Substantial Shareholder Interests
Apr 28, 2025

PYC Therapeutics Limited has announced a change in the interests of a substantial holder, Australian Land Pty Ltd, and other entities associated with Mr. Alan Tribe. The change, effective from April 23, 2025, reflects a shift in voting power due to a series of entitlement offers and share consolidations. This adjustment in shareholding structure may impact the company’s governance dynamics and influence future strategic decisions.

PYC Therapeutics Reports Positive Clinical Trial Results for Eye Disease Treatment
Apr 28, 2025

PYC Therapeutics announced promising results from Phase 1/2 clinical trials of its drug candidate VP-001, aimed at treating Retinitis Pigmentosa type 11. The data, to be presented at upcoming international conferences, shows significant improvements in vision and quality of life for patients, with the drug being safe and well-tolerated. This positions PYC’s platform technology as a valuable tool in addressing blinding eye diseases, with plans to discuss a New Drug Application pathway with the FDA in June 2025.

PYC Therapeutics Advances Towards Commercial Stage with Extended Funding
Apr 23, 2025

PYC Therapeutics has made significant progress in Q1 2025 towards becoming a commercial-stage drug developer, extending its cash runway to over $200 million through a $146 million Entitlement Offer. This funding supports the advancement of its drug candidates, including human trials for polycystic kidney disease and ongoing studies in Retinitis Pigmentosa, positioning the company for improved market conditions and stakeholder confidence.

PYC Therapeutics Announces Quotation of New Securities on ASX
Apr 23, 2025

PYC Therapeutics Limited has announced the application for the quotation of 32,313,759 ordinary fully paid securities on the Australian Securities Exchange (ASX), with the issue date set for April 24, 2025. This move is part of previously announced transactions and is expected to enhance the company’s financial flexibility, potentially impacting its market positioning and providing opportunities for stakeholders.

PYC Therapeutics Secures $146 Million in Entitlement Offer to Advance RNA Therapies
Apr 16, 2025

PYC Therapeutics Limited has successfully completed its Entitlement Offer, raising approximately $146 million, which contributes to a cash runway exceeding $200 million. This financial boost will support the company in advancing its pipeline of first-in-class drug candidates, with human safety and efficacy read-outs expected over the next 24 months, potentially strengthening its position in the precision medicine industry.

PYC Therapeutics Advances PYC-003 in Polycystic Kidney Disease Trial
Apr 9, 2025

PYC Therapeutics Limited has announced the dosing of the first subject in its Phase 1a clinical trial for PYC-003, a drug candidate aimed at treating Polycystic Kidney Disease (PKD). This trial marks a significant step in addressing PKD, a condition with no current treatment options, and if successful, could lead to a rapid approval process following a combined Phase 2/3 study. The trial will assess the safety and efficacy of PYC-003, with plans to escalate dosing and expand the study to include patients with PKD later in 2025.

PYC Therapeutics Secures Majority of Entitlement Offer Amid Underwriter Delays
Apr 9, 2025

PYC Therapeutics Limited announced progress in its ~$146 million Entitlement Offer, having secured ~$133 million so far, which extends its cash runway to over $200 million. However, the underwriter for the remaining ~$13 million has requested an extension due to liquidity issues, prompting PYC to seek payment guarantees and a bond to mitigate potential risks, which could impact the company’s financial stability and stakeholder confidence.

PYC Therapeutics Updates Investors on Business Progress
Mar 27, 2025

PYC Therapeutics Limited has released a presentation to update investors on its business progress. The presentation, intended as an aid, emphasizes the company’s ongoing commitment to advancing its therapeutic developments. However, it advises caution regarding forward-looking statements due to potential risks and uncertainties that could impact future outcomes.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jun 24, 2025