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Botanix Pharmaceuticals Limited (AU:BOT)
ASX:BOT

Botanix Pharmaceuticals Limited (BOT) AI Stock Analysis

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AU:BOT

Botanix Pharmaceuticals Limited

(Sydney:BOT)

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Neutral 47 (OpenAI - 5.2)
Rating:47Neutral
Price Target:
AU$0.12
▼(-15.71% Downside)
The score is held down primarily by weak financial performance driven by very large losses and heavy, worsening cash burn despite improved revenue and gross margin. Technicals remain soft with the stock below key longer-term moving averages and negative MACD, while valuation offers limited support given the negative P/E and lack of dividend data.
Positive Factors
Revenue Growth
The significant increase in revenue indicates strong market demand and successful product adoption, enhancing long-term growth prospects.
Product Launch Success
The successful launch and FDA approval of Sofdra position Botanix strongly in the dermatology market, supporting sustained revenue growth.
Market Position
Investments in sales and distribution enhance Botanix's competitive edge, improving market penetration and customer reach.
Negative Factors
Cash Burn
High cash burn rate indicates reliance on external funding, posing risks to financial stability and limiting strategic flexibility.
Profitability Challenges
Persistent losses and weak margins highlight inefficiencies, challenging Botanix's ability to achieve sustainable profitability.
Balance Sheet Leverage
Moderate leverage with high debt levels can strain resources, impacting long-term financial health and investment capacity.

Botanix Pharmaceuticals Limited (BOT) vs. iShares MSCI Australia ETF (EWA)

Botanix Pharmaceuticals Limited Business Overview & Revenue Model

Company DescriptionBotanix Pharmaceuticals Limited engages in the research and development of dermatology and antimicrobial products in Australia. The company engages in development of novel treatments for common skin diseases and infections. Its product pipeline includes Sofpironium Bromide, a drug in development for the treatment of primary axillary hyperhidrosis that has completed Phase 3 clinical programs; BTX 1503, a transdermal gel formulation for the treatment of serious acne in adults and teenagers that has completed Phase II clinical trials; BTX 1801, which has completed Phase IIb clinical trials for the treatment of staphylococcus aureus and methicillin resistant staphylococcus aureus; BTX 1702 that is in Phase IIb clinical trials for the treatment of papulopustular rosacea; and BTX 1204A for the treatment of atopic dermatitis. The company was incorporated in 1984 and is based in Leederville, Australia.
How the Company Makes MoneyBotanix Pharmaceuticals Limited makes money through the development and commercialization of its dermatological products, primarily leveraging its proprietary Permetrex technology. The company's revenue model revolves around licensing agreements, partnerships, and collaborations with larger pharmaceutical companies, enabling them to bring their products to market. These collaborations often involve upfront payments, milestone payments based on the achievement of certain development or regulatory milestones, and royalties on future sales. Additionally, Botanix may generate revenue from the direct sale of its approved products to healthcare providers and patients.

Botanix Pharmaceuticals Limited Financial Statement Overview

Summary
Botanix Pharmaceuticals Limited faces significant profitability challenges with consistently negative margins and declining revenues. Despite a strong balance sheet with no debt, the cash flow statement reflects liquidity pressures and a reliance on external financing.
Income Statement
24
Negative
Botanix Pharmaceuticals Limited shows declining revenue year-over-year with a significant net loss, indicating challenges in achieving profitability. The gross profit margin is negative, which raises concerns about cost management and operational efficiency. The recurring negative EBIT and EBITDA margins highlight ongoing operational losses.
Balance Sheet
55
Neutral
The company maintains a strong equity position with no debt, resulting in a zero debt-to-equity ratio, which is positive for financial stability. However, the equity ratio is relatively high, suggesting limited leverage capacity. The company's assets are primarily funded by equity, highlighting a conservative financial structure.
Cash Flow
26
Negative
Botanix Pharmaceuticals exhibits negative free cash flow, indicating a cash burn situation. The operating cash flow to net income ratio is negative, suggesting operational inefficiencies. Despite a substantial financing inflow, the company struggles to generate positive free cash flow.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue5.79M5.79M601.82K914.97K2.75M6.89M
Gross Profit2.02M2.02M-6.12M-3.05M-7.54M315.80K
EBITDA-80.65M-80.65M-15.25M-12.63M-15.74M-10.06M
Net Income-86.40M-86.40M-13.87M-9.15M-13.17M-3.33M
Balance Sheet
Total Assets129.10M129.10M112.46M24.84M14.04M21.95M
Cash, Cash Equivalents and Short-Term Investments64.97M64.97M79.31M10.25M7.29M21.55M
Total Debt32.51M32.51M0.000.00122.41K259.32K
Total Liabilities47.80M47.80M3.73M1.88M5.89M1.15M
Stockholders Equity81.30M81.30M108.73M22.95M8.15M20.80M
Cash Flow
Free Cash Flow-78.87M-78.87M-26.13M-19.13M-14.11M-2.98M
Operating Cash Flow-78.58M-78.58M-8.13M-12.07M-11.18M-2.97M
Investing Cash Flow-1.05M-1.05M-18.00M-7.05M-2.92M-8.28K
Financing Cash Flow65.36M65.36M95.10M22.03M-152.41K-125.50K

Botanix Pharmaceuticals Limited Technical Analysis

Technical Analysis Sentiment
Positive
Last Price0.14
Price Trends
50DMA
0.12
Positive
100DMA
0.13
Positive
200DMA
0.22
Negative
Market Momentum
MACD
<0.01
Negative
RSI
65.86
Neutral
STOCH
68.37
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:BOT, the sentiment is Positive. The current price of 0.14 is above the 20-day moving average (MA) of 0.13, above the 50-day MA of 0.12, and below the 200-day MA of 0.22, indicating a neutral trend. The MACD of <0.01 indicates Negative momentum. The RSI at 65.86 is Neutral, neither overbought nor oversold. The STOCH value of 68.37 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for AU:BOT.

Botanix Pharmaceuticals Limited Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
73
Outperform
AU$613.95M16.9315.90%0.38%7.76%1.55%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
AU$677.91M-10.90-35.86%-19.21%
48
Neutral
AU$333.22M-23.32-83.97%1271.12%36.87%
47
Neutral
AU$265.72M-2.88-90.93%456.50%-457.14%
42
Neutral
AU$738.77M-2.95-80.08%59.91%
41
Neutral
AU$276.73M-28.41-89.70%42.05%-0.84%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AU:BOT
Botanix Pharmaceuticals Limited
0.14
-0.33
-70.21%
AU:OPT
Opthea
0.60
-0.18
-22.58%
AU:CUV
Clinuvel Pharmaceuticals
12.23
0.50
4.24%
AU:OCC
Orthocell Ltd
1.02
-0.30
-22.73%
AU:IMM
Immutep Ltd
0.46
0.14
41.54%
AU:DXB
Dimerix Limited
0.56
0.04
6.73%

Botanix Pharmaceuticals Limited Corporate Events

Botanix Pharmaceuticals Cancels Shares Under Employee Scheme Buy-Back
Dec 29, 2025

Botanix Pharmaceuticals has cancelled 6,928,586 fully paid ordinary shares following an employee share scheme buy-back, effective 29 December 2025. The reduction in issued capital marginally tightens the company’s share base and may have implications for existing shareholders by modestly improving per-share metrics and signalling active management of its employee equity programs.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Completes Final Employee Share Scheme Buy-Back
Dec 29, 2025

Botanix Pharmaceuticals has completed an employee share scheme buy-back of 6,928,586 ordinary fully paid shares, as disclosed in its final buy-back notification to the ASX dated 30 December 2025. The transaction, recorded with zero consideration payable, appears to be a technical or administrative cancellation of securities under an employee scheme, modestly tightening the company’s share base and potentially affecting equity allocation among existing shareholders without implying a cash outlay by the company.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Details Daily Progress of Employee Share Scheme Buy-Back
Dec 29, 2025

Botanix Pharmaceuticals has updated the market on its ongoing employee share scheme buy-back, confirming that 6,928,586 ordinary fully paid shares were repurchased on the previous trading day, with no shares bought back before that date. The daily notification underscores the company’s active capital management via buy-backs under its employee equity arrangements, which can influence its share structure and may have implications for existing shareholders’ ownership percentages and the liquidity of BOT shares.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Grants 8.75 Million Unquoted Options Under Employee Incentive Scheme
Dec 24, 2025

Botanix Pharmaceuticals has notified the market of the issue of 8.75 million unquoted options, each exercisable at A$0.125 and expiring on 24 December 2029, under an employee incentive scheme. The award of these unlisted options, which are not intended to be quoted on the ASX, is designed to align staff incentives with shareholder value creation and may modestly increase potential future dilution if exercised.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Seeks ASX Quotation for 4.6 Million New Shares
Dec 19, 2025

Botanix Pharmaceuticals has applied for quotation on the ASX of 4.6 million new ordinary fully paid shares, following the issue of these securities on 18 December 2025. The additional quotation expands the company’s listed share capital, potentially enhancing liquidity in its stock and providing greater flexibility for capital management and future corporate activities.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Announces Employee Share Buy-Back
Dec 10, 2025

Botanix Pharmaceuticals Limited has announced a buy-back of ordinary fully paid shares under an employee share scheme. This move is part of the company’s strategy to manage its capital structure and incentivize its employees, potentially enhancing shareholder value and aligning employee interests with company goals.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Reports 2025 AGM Results with Key Resolutions Passed
Nov 20, 2025

Botanix Pharmaceuticals announced the results of its 2025 Annual General Meeting, where all resolutions were passed except for the approval of the Remuneration Report. The meeting included the re-election of directors and the ratification of placement shares issued to investors, indicating continued support from shareholders and strategic positioning in the market.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Reports Strong Growth Following Sofdra Launch
Nov 19, 2025

Botanix Pharmaceuticals Limited has successfully transitioned into a commercial revenue-generating company following the acquisition and FDA approval of its lead asset, Sofdra. The company reported significant growth in sales and revenue in its second full quarter post-launch, with a 50% increase in total prescriptions and a 65% rise in net revenue. The expansion of its sales force and the development of a differentiated fulfillment platform have been pivotal in driving this success, positioning Botanix strongly within the dermatology market.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Opts Out of ASX Waiver for Loan Facility
Oct 21, 2025

Botanix Pharmaceuticals announced that it has received a partial waiver from the ASX Listing Rule 7.5.4, which would have allowed the company to seek shareholder approval for the ratification of a loan facility agreement at its annual general meeting. However, the company has decided not to rely on this waiver, as its current placement capacity is sufficient to meet its obligations. This decision indicates a strong financial position and operational flexibility, potentially reassuring stakeholders about the company’s ability to manage its financial commitments without diluting shareholder value.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals to Present at Canaccord Conference in Noosa
Oct 20, 2025

Botanix Pharmaceuticals announced that its CEO, Dr. Howie McKibbon, will present at the Canaccord Drug and Device Healthcare Conference in Noosa. The presentation aims to engage institutional investors and is part of a broader investor roadshow hosted by Canaccord Genuity. This event is significant as it provides Botanix an opportunity to showcase its FDA-approved product, Sofdra®, and potentially strengthen its market position and investor relations.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Releases Q1 FY26 Investor Update
Oct 19, 2025

Botanix Pharmaceuticals Limited has released its Q1 FY26 investor update, highlighting the company’s strategic plans and market positioning. The update includes insights into the company’s operations, potential regulatory approvals, and the commercial prospects of its product candidates, such as Sofdra®. This announcement is significant for stakeholders as it outlines Botanix’s future direction and potential market impact, although it is accompanied by the usual risks and uncertainties inherent in the pharmaceutical industry.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Schedules Annual General Meeting for November 2025
Oct 16, 2025

Botanix Pharmaceuticals Limited has announced its Annual General Meeting scheduled for November 20, 2025, in Perth, Western Australia. Shareholders are encouraged to lodge their proxy forms online or via other specified methods before the meeting. This meeting is crucial for stakeholders as it provides an opportunity to discuss the company’s strategic direction and operational updates, potentially impacting future business decisions.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Schedules Annual General Meeting for November 2025
Oct 16, 2025

Botanix Pharmaceuticals Limited has announced its Annual General Meeting (AGM) scheduled for November 20, 2025, in Perth, Western Australia. The meeting will address key business matters, including the consideration of financial reports and a non-binding resolution on the remuneration report for the year ended June 30, 2025. This AGM is crucial for shareholders to engage with the company’s financial and strategic direction, impacting its governance and stakeholder relations.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Announces Cessation of Securities
Oct 16, 2025

Botanix Pharmaceuticals Limited has announced the cessation of several securities due to the lapse of conditional rights, as the conditions for these securities have not been met or have become incapable of being satisfied. This announcement may impact the company’s financial structuring and could influence investor perceptions, potentially affecting its market positioning.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Botanix Pharmaceuticals Issues New Securities to Boost Employee Engagement
Oct 16, 2025

Botanix Pharmaceuticals Limited announced the issuance of 4.5 million performance rights and 13.5 million options exercisable at $0.11 each, expiring in 2030, as part of an employee incentive scheme. This move is expected to enhance employee engagement and align their interests with the company’s long-term growth objectives, potentially strengthening Botanix’s position in the pharmaceutical industry.

The most recent analyst rating on (AU:BOT) stock is a Buy with a A$2.00 price target. To see the full list of analyst forecasts on Botanix Pharmaceuticals Limited stock, see the AU:BOT Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025