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Opthea Limited (AU:OPT)
ASX:OPT

Opthea (OPT) AI Stock Analysis

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AU

Opthea

(Sydney:OPT)

Rating:30Underperform
Price Target:
Opthea Limited's overall score is significantly impacted by its weak financial performance, with persistent losses and negative equity suggesting high risk. Technical analysis reflects bearish sentiment, although oversold indicators suggest a potential for short-term recovery. Valuation concerns due to negative earnings further weigh on the score, making it a high-risk investment.

Opthea (OPT) vs. iShares MSCI Australia ETF (EWA)

Opthea Business Overview & Revenue Model

Company DescriptionOpthea Limited, a clinical stage biopharmaceutical company, develops and commercializes therapies primarily for eye disease in Australia. The company's development activities are based on the intellectual property portfolio covering Vascular Endothelial Growth Factors (VEGF) VEGF-C, VEGF-D, and VEGF Receptor-3 for the treatment of diseases associated with blood and lymphatic vessel growth, as well as vascular leakage. Its lead asset is OPT 302, a soluble form of VEGFR 3 in clinical development as a novel therapy for wet neovascular age related macular degeneration and diabetic macular edema (DME), as well as a first in class VEGF-C/D inhibitors for treatment with VEGF-A inhibitors to treat wet neovascular AMD and other retinal diseases. The company was formerly known as Circadian Technologies Limited and changed its name to Opthea Limited in December 2015. Opthea Limited was incorporated in 1984 and is based in South Yarra, Australia.
How the Company Makes MoneyOpthea Limited primarily generates revenue through the development and commercialization of its proprietary therapies targeting eye diseases. The company's revenue model is focused on advancing its lead candidate, OPT-302, through various stages of clinical trials and eventually obtaining regulatory approval for its commercial use. Once approved, Opthea plans to monetize OPT-302 through direct sales, licensing agreements, and potential strategic partnerships with other pharmaceutical companies. These partnerships could involve co-development, co-marketing, or royalty-based agreements, providing significant revenue streams. Additionally, Opthea may secure funding through grants, research collaborations, and equity financing to support ongoing research and development activities.

Opthea Financial Statement Overview

Summary
Opthea Limited faces significant financial challenges with persistent losses, negative equity, and reliance on external financing. The company's financial health is weak, with limited signs of improvement in profitability or cash flow stability, posing high risks to stakeholders.
Income Statement
20
Very Negative
Opthea Limited shows persistent net losses with a negative net profit margin of -176651% for the recent year, indicating significant challenges in achieving profitability. The gross profit margin is positive but does not offset operating losses, as evidenced by the negative EBIT and EBITDA margins. Revenue growth is volatile with significant fluctuations.
Balance Sheet
15
Very Negative
The balance sheet reveals negative stockholders' equity, suggesting financial instability. High debt levels lead to a negative equity ratio, and the debt-to-equity ratio is not meaningful due to negative equity. The company is heavily reliant on debt and external financing.
Cash Flow
30
Negative
Opthea's cash flow situation shows substantial negative free cash flow, reflecting ongoing operational challenges. The operating cash flow to net income ratio is negative, indicating that cash outflows exceed earnings. The company relies on financing activities to sustain operations.
Breakdown
Jun 2024Jun 2023Jun 2022Jun 2021Jun 2020
Income StatementTotal Revenue
124.67K161.16K125.05K91.98K145.90K
Gross Profit
124.67K-89.31K-107.42K-480.00K-371.37K
EBIT
-191.84M-223.45M-133.27M-53.18M-24.70M
EBITDA
-199.29M-223.30M-133.16M-52.85M-24.92M
Net Income Common Stockholders
-220.24M-211.88M-127.99M-60.79M-16.12M
Balance SheetCash, Cash Equivalents and Short-Term Investments
172.47M133.99M64.90M157.43M62.02M
Total Assets
188.79M148.19M87.32M184.36M71.89M
Total Debt
141.65M272.98K0.00150.47K265.08K
Net Debt
-30.82M-133.71M-64.90M-157.28M-61.76M
Total Liabilities
264.60M156.98M17.55M4.16M7.08M
Stockholders Equity
-75.81M-8.79M69.77M180.20M64.81M
Cash FlowFree Cash Flow
-161.05M-179.34M-98.39M-61.08M
Operating Cash Flow
-161.02M-179.30M-98.37M-61.06M-8.24M
Investing Cash Flow
-33.49K-32.64K-23.32K880.07K482.83K
Financing Cash Flow
243.73M248.70M236.62K156.76M48.06M

Opthea Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.60
Price Trends
50DMA
0.60
Negative
100DMA
0.73
Negative
200DMA
0.73
Negative
Market Momentum
MACD
>-0.01
Negative
RSI
21.86
Positive
STOCH
25.00
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:OPT, the sentiment is Negative. The current price of 0.6 is above the 20-day moving average (MA) of 0.60, below the 50-day MA of 0.60, and below the 200-day MA of 0.73, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 21.86 is Positive, neither overbought nor oversold. The STOCH value of 25.00 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for AU:OPT.

Opthea Peers Comparison

Overall Rating
UnderperformOutperform
Sector (54)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
AURAC
54
Neutral
AU$203.27M-37.20%32.02%
54
Neutral
$5.38B3.31-45.11%3.29%16.82%0.04%
AUCU6
53
Neutral
AU$768.03M-53.99%-40.19%
AUBOT
53
Neutral
AU$666.70M-56.99%10.76%-195.89%
AUDXB
46
Neutral
AU$332.21M-524.68%322.26%-53.98%
AUOPT
30
Underperform
$738.77M
-24.46%-7.90%
$260.76M-31.16%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AU:OPT
Opthea
0.60
0.24
64.38%
PRRUF
Immutep Ltd
0.19
-0.10
-34.48%
AU:DXB
Dimerix Limited
0.56
-0.08
-12.50%
AU:RAC
Race Oncology Ltd.
1.15
-0.64
-35.75%
AU:CU6
Clarity Pharmaceuticals Ltd.
2.34
-2.88
-55.17%
AU:BOT
Botanix Pharmaceuticals Limited
0.32
-0.01
-3.03%

Opthea Corporate Events

Opthea Announces Director Change: Quinton Oswald Steps Down
Jun 2, 2025

Opthea Limited announced the cessation of Quinton Oswald as a director effective June 2, 2025. This change in the board may influence the company’s strategic direction, particularly in its ongoing development of treatments for eye diseases. Oswald held significant unquoted options, which may impact stakeholder interests and the company’s financial strategies moving forward.

The most recent analyst rating on (AU:OPT) stock is a Buy with a A$1.25 price target. To see the full list of analyst forecasts on Opthea stock, see the AU:OPT Stock Forecast page.

Opthea Announces Director Change and Securities Update
Jun 2, 2025

Opthea Limited has announced the cessation of Susan Orr as a director, effective June 2, 2025. This update, provided under listing rule 3.19A.3, includes details of her interests in unquoted options to purchase shares, which may have implications for the company’s governance and strategic direction.

The most recent analyst rating on (AU:OPT) stock is a Buy with a A$1.25 price target. To see the full list of analyst forecasts on Opthea stock, see the AU:OPT Stock Forecast page.

Opthea Announces Director Departure and Impact on Strategic Direction
Jun 2, 2025

Opthea Limited announced the cessation of Julia Haller as a director of the company, effective June 2, 2025. This change in the board of directors could impact the company’s strategic direction and stakeholder interests, as Haller held significant unquoted options in the company, which could influence market perceptions and investor confidence.

The most recent analyst rating on (AU:OPT) stock is a Buy with a A$1.25 price target. To see the full list of analyst forecasts on Opthea stock, see the AU:OPT Stock Forecast page.

Opthea Faces Leadership Changes Amidst Clinical Trial Setbacks
Jun 1, 2025

Opthea Limited announced the resignation of four directors following the failure of its Phase 3 trials to meet primary endpoints and a significant workforce reduction. The company is in negotiations with Development Funding Agreement investors to explore future options, amidst trading suspensions on ASX and Nasdaq due to financial uncertainties.

The most recent analyst rating on (AU:OPT) stock is a Buy with a A$1.25 price target. To see the full list of analyst forecasts on Opthea stock, see the AU:OPT Stock Forecast page.

JPMorgan Ceases Substantial Holding in Opthea
May 11, 2025

Opthea Ltd has announced that JPMorgan Chase & Co. and its affiliates have ceased to be substantial holders of the company’s voting securities. This change in holdings, involving several subsidiaries of JPMorgan, indicates a shift in the investment landscape for Opthea, potentially impacting its market dynamics and stakeholder interests.

Opthea Halts Wet AMD Trials and Cuts Workforce Amid Financial Uncertainty
Apr 30, 2025

Opthea announced the discontinuation of its wet AMD trials after the COAST and ShORE Phase III trials failed to meet primary endpoints, leading to a 65% reduction in staff. The company remains in discussions with its Development Funding Agreement investors to explore options for the future, amid uncertainties about its ability to continue as a going concern. Opthea’s cash balance decreased to $101.4 million by the end of March 2025, reflecting operational spending and trial advancements, while the company is in trading suspension.

Opthea Announces Major Workforce Reduction Following Trial Setbacks
Apr 10, 2025

Opthea Limited has announced a significant reduction in its workforce by approximately 65% following negative results from its Phase 3 clinical trials for OPT-302 in combination with Aflibercept and Ranibizumab. This decision aims to conserve cash, with estimated cash reserves of US$100M as of March 2025, amid ongoing negotiations with Development Funding Agreement investors. The workforce reduction is expected to save around US$1M monthly in employee costs, although it raises concerns about the company’s ability to continue as a going concern, with trading in its securities suspended until further clarity is provided.

Opthea Limited’s Securities Suspended Due to Financial Concerns
Mar 31, 2025

Opthea Limited, a company listed on the Australian Securities Exchange (ASX), has had its securities suspended from quotation due to concerns over its financial condition. The ASX determined that Opthea’s financial status does not meet the requirements for continued quotation, resulting in a breach of Listing Rule 12.2. The suspension will remain in effect until Opthea complies with the necessary listing rules, impacting the company’s operations and market position.

Opthea Halts Wet AMD Trials Following Unsuccessful Phase 3 Results
Mar 31, 2025

Opthea Limited has announced the discontinuation of its Phase 3 trials, COAST and ShORe, for wet AMD after the trials did not meet their primary endpoints. The company is assessing the impact of these negative results on its Development Funding Agreement and its status as a going concern. Opthea’s financial stability is uncertain, with ongoing discussions with investors and a suspension of trading in its securities until further clarity is provided.

JPMorgan Chase Acquires Substantial Stake in Opthea Limited
Mar 30, 2025

JPMorgan Chase & Co. and its affiliates have become a substantial holder in Opthea Limited, acquiring a 5.18% voting power through various securities transactions. This development signifies a significant investment by a major financial institution, potentially impacting Opthea’s market dynamics and signaling confidence in the company’s future prospects.

JPMorgan Ceases to be Substantial Holder in Opthea Limited
Mar 25, 2025

Opthea Limited has announced that JPMorgan Chase & Co. and its affiliates have ceased to be substantial holders in the company as of March 20, 2025. This change involves various transactions related to securities lending and rehypothecation agreements, impacting the voting securities previously held by JPMorgan’s subsidiaries. The cessation of JPMorgan as a substantial holder may affect Opthea’s market dynamics and stakeholder interests, as it reflects a shift in the company’s shareholder composition.

Opthea Limited Suspends Trading Pending Clinical Trial Results
Mar 18, 2025

Opthea Limited has requested a voluntary suspension of its securities from trading on the ASX pending the announcement of results from its Phase 3 COAST clinical trial. This suspension is intended to maintain market stability until the company can release the top line results, which are expected to have significant implications for its operations and market positioning.

Opthea Limited Initiates Trading Halt Ahead of Key Clinical Trial Results
Mar 16, 2025

Opthea Limited has requested a trading halt on its securities pending the announcement of the top line results from its Phase 3 COAST clinical trial, which combines OPT-302 with Aflibercept. This trading halt indicates the potential significance of the trial results, which could impact Opthea’s market position and stakeholder interests, as the outcomes may influence future operations and strategic decisions.

JPMorgan Acquires Substantial Stake in Opthea Limited
Mar 14, 2025

JPMorgan Chase & Co. and its affiliates have become substantial holders in Opthea Limited, acquiring a 5.10% voting power through various securities lending and brokerage agreements. This acquisition signifies a strategic investment by a major financial institution, potentially impacting Opthea’s market position and signaling confidence in its future prospects, which could influence stakeholder perceptions and market dynamics.

Opthea Limited Announces New Quotation of Securities on ASX
Mar 14, 2025

Opthea Limited has announced a new application for the quotation of securities on the Australian Securities Exchange (ASX). The announcement involves the quotation of 896 ordinary fully paid securities, which were issued as a result of options being exercised or other convertible securities being converted. This development is part of Opthea’s ongoing efforts to enhance its financial flexibility and strengthen its market position in the biotechnology sector.

Opthea Limited Announces Quotation of New Securities on ASX
Mar 14, 2025

Opthea Limited has announced the quotation of new securities on the Australian Securities Exchange (ASX). The company is issuing 956 fully paid ordinary shares, which could impact its financial structure and potentially influence investor sentiment. This move is part of Opthea’s strategic efforts to strengthen its capital base and support its ongoing research and development initiatives.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.