Clinical Trial ProgressThe Aspen-Breast trial starts enrollment this quarter with an interim readout planned, using centralized CD47 testing and ctDNA-based HER2 confirmation.
Innovative Drug DesignEvorpacept’s differentiation is attributed to its fully 'dead-Fc' design, which eliminates macrophage-activating effector function—the flaw that caused every prior CD47 program to have limiting on-target hematologic toxicity.
Market PotentialALX believes there are ~20K addressable patients with CD47-high 2L+ HER2+ breast cancer in the US, EU5.