Labeling ConcernsThe updated label for Pyrukynd includes a warning for liver injury, which has been an overhang for AGIO shares, contributing to a significant decline in stock value.
Risk PerceptionInvestor concerns exist regarding the efficacy bar, the risk of hepatocellular injury, and the overall risk/benefit of the drug.
Safety ConcernsConcerns over hepatocellular injury have negatively impacted AGIO stock, which is down approximately 45% due to these issues observed in thalassemia patients.