Alzheimer's DiseaseObi leads to statistically significant and clinically meaningful reductions in p-tau217, a biomarker associated with Alzheimer's disease.
Cardiovascular BenefitsAn exploratory endpoint analysis from BROADWAY demonstrated a 21% reduction in the occurrence of 4-point major adverse cardiovascular events (MACE), indicating potential for CV benefits beyond LDL-C.
Clinical TrialsObicetrapib has exhibited significant LDL-C reductions vs. placebo in multiple Phase 3 trials, alone or in combination with ezetimibe, as an adjunct to statin therapy.