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Affimed (AFMD)
NASDAQ:AFMD

Affimed (AFMD) AI Stock Analysis

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Affimed

(NASDAQ:AFMD)

42Neutral
Affimed's overall stock score reflects its financial struggles, with declining revenue and increasing losses being major concerns. The stock is technically weak, and the valuation is challenging due to negative earnings. Positive aspects from the earnings call, such as strategic progress in clinical trials and reduced losses, provide some optimism but are outweighed by financial and operational challenges.
Positive Factors
Business Development
Affimed’s three active molecules should be of interest to pharma, and a partnership with non-dilutive financing would provide significant support for the stock.
Clinical Data
AFMD highlighted positive data from the LuminICE-203 study in cHL, showing significantly higher ORR compared to the only currently available option.
Clinical Efficacy
New AFM24 + atezolizumab data in anti-PD-(L)1 relapsed / refractory EGFRwt non-small cell lung cancer confirm clinical activity and hint at durability of benefit that could translate to a meaningful 'long tail' benefit over cytotoxic-based alternatives.
Negative Factors
Financial Concerns
The initiation of the PTCL cohort in LuminICE-203 is contingent upon securing additional capital.
Funding Uncertainty
There is a 1-1.5 year delay and uncertainty in source of funding for the higher dose strategy.
Price Target Adjustment
The price target is adjusted from $15 to $11, reflecting updated model assumptions on patient numbers and market penetration.

Affimed (AFMD) vs. S&P 500 (SPY)

Affimed Business Overview & Revenue Model

Company DescriptionAffimed N.V., a clinical-stage biopharmaceutical company, focuses on discovering and developing cancer immunotherapies in the United States, Germany, and rest of Europe. Its lead product candidate is AFM13, which has completed Phase II clinical study for peripheral T-cell lymphoma; in Phase IIa clinical trial for CD30-positive lymphoma; and in Phase I clinical trial for hodgkin lymphoma. The company is also developing AFM24, a tetravalent, bispecific epidermal growth factor receptor, and CD16A-binding innate cell engager, which is in Phase IIa clinical trial for the treatment of advanced cancers; AFM28, an innate cell engager (ICE), which is in preclinical development to treat acute myeloid leukemia; and AFM32, an ICE candidate that is in preclinical development for the treatment of solid tumors. Affimed N.V. has collaboration agreements with The University of Texas MD Anderson Cancer Center; Genentech, Inc.; and Roivant Sciences Ltd., as well as research funding agreement with The Leukemia & Lymphoma Society. The company was formerly known as Affimed Therapeutics B.V. and changed its name to Affimed N.V. in October 2014. Affimed N.V. was founded in 2000 and is headquartered in Heidelberg, Germany.
How the Company Makes MoneyAffimed primarily generates revenue through collaboration and license agreements with pharmaceutical companies, where they develop and commercialize their drug candidates. These agreements often include upfront payments, milestone payments based on the achievement of clinical, regulatory, and commercial milestones, and royalties on sales of commercialized products. Additionally, Affimed may receive funding from grants and research collaborations that support their development programs. Significant partnerships with larger pharmaceutical companies also contribute to their revenue by providing financial support and resources for advancing their therapeutic candidates through clinical trials.

Affimed Financial Statement Overview

Summary
Affimed is experiencing significant financial challenges, with declining revenues and increasing losses. The company's high leverage and negative cash flows raise concerns about its ability to sustain operations without external financing. Despite these challenges, the company holds a modest cash reserve, which provides some liquidity cushion.
Income Statement
45
Neutral
The company's revenue has decreased significantly, from $41.35M in 2022 to $0.877M in the TTM. The gross profit margin remains at 100%, but the net profit margin is extremely negative due to high losses, with a negative net income of $69.97M in the TTM. The EBIT and EBITDA margins are also deeply negative, indicating operational challenges.
Balance Sheet
50
Neutral
The debt-to-equity ratio has increased, suggesting rising leverage, with total debt at $12.89M against stockholders' equity of $17.19M. The equity ratio is declining, reflecting reduced equity relative to total assets. However, the company maintains a reasonable amount of cash and short-term investments at $24.94M.
Cash Flow
40
Negative
Operating cash flow and free cash flow are negative, indicating cash burn issues, with operating cash flow at -$76.90M in the TTM. The free cash flow growth rate is negative, suggesting increasing cash flow challenges. The ratios of cash flow to net income are unfavorable, highlighting cash flow inefficiencies.
Breakdown
Dec 2023Dec 2022Dec 2021Dec 2020Dec 2019
Income StatementTotal Revenue
8.28M41.35M40.37M28.36M21.39M
Gross Profit
8.28M41.35M40.37M28.36M21.39M
EBIT
-106.66M-88.12M-64.03M-34.72M-32.38M
EBITDA
-102.38M-81.47M-64.01M-34.23M-30.97M
Net Income Common Stockholders
-105.94M-86.00M-57.52M-41.37M-32.37M
Balance SheetCash, Cash Equivalents and Short-Term Investments
72.90M190.29M197.63M146.85M104.14M
Total Assets
97.16M200.51M225.13M175.72M112.36M
Total Debt
19.35M18.19M18.69M1.30M3.19M
Net Debt
-19.18M-172.10M-178.94M-145.56M-92.05M
Total Liabilities
39.35M47.60M89.18M103.73M73.69M
Stockholders Equity
57.81M152.91M135.95M71.99M38.67M
Cash FlowFree Cash Flow
-114.00M-105.59M-90.44M-19.84M-30.53M
Operating Cash Flow
-110.27M-104.89M-86.59M-19.40M-29.06M
Investing Cash Flow
-36.06M5.61M-3.85M8.01M4.34M
Financing Cash Flow
-6.22M88.56M133.58M69.25M26.04M

Affimed Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price0.99
Price Trends
50DMA
0.85
Positive
100DMA
1.11
Negative
200DMA
2.48
Negative
Market Momentum
MACD
0.03
Negative
RSI
68.46
Neutral
STOCH
87.84
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AFMD, the sentiment is Neutral. The current price of 0.99 is above the 20-day moving average (MA) of 0.73, above the 50-day MA of 0.85, and below the 200-day MA of 2.48, indicating a neutral trend. The MACD of 0.03 indicates Negative momentum. The RSI at 68.46 is Neutral, neither overbought nor oversold. The STOCH value of 87.84 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for AFMD.

Affimed Risk Analysis

Affimed disclosed 67 risk factors in its most recent earnings report. Affimed reported the most risks in the “Tech & Innovation” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Affimed Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$5.35B3.41-40.83%2.89%18.11%2.60%
47
Neutral
$14.12M-8.16%35.25%81.05%
42
Neutral
$14.77M-151.46%-95.23%-325.89%
40
Underperform
$9.67M-66.65%157.63%40.52%
36
Underperform
$11.48M-110.77%18.61%
35
Underperform
$3.32M-100.70%-51.32%-1.76%
24
Underperform
$9.85M-490.03%99.64%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AFMD
Affimed
0.99
-4.34
-81.43%
TXMD
TherapeuticsMD
1.23
-0.65
-34.57%
APRE
Aprea Therapeutics
1.70
-3.55
-67.62%
ATHA
Athira Pharma
0.30
-1.74
-85.29%
SPRB
Spruce Biosciences
0.08
-0.64
-88.89%
RNAZ
TransCode Therapeutics
0.43
-20.35
-97.93%

Affimed Earnings Call Summary

Earnings Call Date:Mar 27, 2025
(Q3-2024)
|
% Change Since: 19.28%|
Next Earnings Date:May 21, 2025
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in clinical trials, particularly with AFM24 and AFM28, and a strategic focus on partnerships and financial health. However, there were notable challenges, including a decline in revenue and reduced cash reserves. Despite these challenges, the company's efforts to improve its financial position and strategic focus are promising.
Q3-2024 Updates
Positive Updates
Clinical Proof of Concept Across Multiple Assets
Affimed has demonstrated clinical proof of concept across three different assets spanning solid tumors and hematologic malignancies, showing activity in both monotherapy and combination studies.
Positive Outcomes for AFM24
In the AFM24-102 trial, 71% disease control rate was observed with a median progression-free survival of 5.9 months in non-small cell lung cancer patients.
AFM28 Achievements
AFM28, targeting CD123 for acute myeloid leukemia, has shown a favorable safety profile with no dose-limiting toxicities at a 300 mg weekly dose.
Financial Health and Strategic Focus
Net loss decreased from EUR 24.4 million in Q3 2023 to EUR 15.1 million in Q3 2024. The company is focused on improving financial health and pursuing strategic partnerships.
Negative Updates
Revenue Decline
Total revenue for the quarter ended September 30, 2024, was EUR 0.2 million, compared with EUR 2 million for the quarter ended September 30, 2023.
Decreased Cash Reserves
Cash and investments decreased to EUR 24.1 million at the end of Q3 2024, down from EUR 72 million at the end of 2023.
R&D and G&A Expense Reductions
R&D expenses decreased to EUR 10.1 million compared to EUR 21.5 million in 2023, and G&A expenses were EUR 4.3 million compared to EUR 5.4 million in 2023.
Company Guidance
During the Affimed Q3 2024 earnings call, significant financial and operational metrics were presented, highlighting the company's progress and future expectations. Affimed reported a cash balance of EUR 24.1 million at the end of Q3 2024, down from EUR 72 million at the end of 2023, indicating a reduction due to operational activities. The net cash used in operating activities was EUR 11.1 million for Q3 2024 compared to EUR 18.3 million in Q3 2023, reflecting improved operational efficiency. Total revenue for the quarter was EUR 0.2 million, a decrease from EUR 2 million in the same period last year, while R&D expenses were reduced to EUR 10.1 million from EUR 21.5 million in Q3 2023. Affimed also reported a net loss of EUR 15.1 million, improving from a net loss of EUR 24.4 million in Q3 2023. The company anticipates that its current financial resources, including expected proceeds from the ATM program and the sale of AbCheck, will fund operations into the fourth quarter of 2025. These metrics underscore Affimed's strategic focus on financial health and operational efficiency as it advances its clinical programs and seeks potential partnerships.
Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.