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Addex Therapeutics Ltd (ADR) (ADXN)
:ADXN
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Addex Therapeutics (ADXN) AI Stock Analysis

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ADXN

Addex Therapeutics

(NASDAQ:ADXN)

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Neutral 44 (OpenAI - 4o)
Rating:44Neutral
Price Target:
$8.00
▼(-26.94% Downside)
Addex Therapeutics' overall stock score reflects significant financial challenges, with persistent losses and cash flow issues being the most impactful factors. While there are positive developments in strategic partnerships and R&D, the technical indicators and valuation metrics suggest caution. The company's financial stability and progress in partnerships provide some support, but the risks associated with its financial performance and valuation weigh heavily on the score.

Addex Therapeutics (ADXN) vs. SPDR S&P 500 ETF (SPY)

Addex Therapeutics Business Overview & Revenue Model

Company DescriptionAddex Therapeutics is a clinical-stage biopharmaceutical company focused on developing innovative treatments for central nervous system (CNS) disorders. The company specializes in allosteric modulation, which involves the development of compounds targeting metabotropic glutamate receptors (mGluRs) to address various neurological and psychiatric conditions. Addex's pipeline includes candidates for treating indications such as Parkinson's disease, schizophrenia, and anxiety disorders, aiming to improve patient outcomes through novel mechanisms of action.
How the Company Makes MoneyAddex Therapeutics generates revenue primarily through the development and commercialization of its pharmaceutical products. The company's revenue model includes potential milestone payments from strategic partnerships with larger pharmaceutical companies that may license its drug candidates for further development and marketing. Additionally, Addex may receive royalties on sales of products that are successfully commercialized as a result of these partnerships. The company also engages in research collaborations and grants that can provide funding for its ongoing development programs, contributing to its financial sustainability.

Addex Therapeutics Earnings Call Summary

Earnings Call Date:Sep 30, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 10, 2025
Earnings Call Sentiment Neutral
The earnings call presented a balanced view with significant achievements in collaborative and strategic partnerships, financial stability, and progress in R&D. However, there were challenges related to decreased income, increased net loss from an associated venture, and limited cash for unpartnered programs.
Q2-2025 Updates
Positive Updates
Successful Completion of IND-Enabling Studies
Indivior completed IND-enabling studies for a GABAB PAM drug candidate for substance use disorders, a key milestone in their partnership.
Regained Rights to mGlu2 Program
Addex regained rights to the mGlu2 positive allosteric modulator program, including the Phase II asset ADX71149, from Johnson & Johnson.
Investment in Stalicla
Invested in Stalicla, a neurodevelopmental disorder-focused company, which has developed a precision medicine platform for patient stratification.
Financial Stability
Completed the half year with CHF 2.3 million in cash, providing a runway through mid-2026.
Reduced Cash Burn
Cash burn significantly reduced following the Neurosterix spin-out transaction.
Negative Updates
Decrease in Income
Income decreased by CHF 0.1 million in Q2 2025 compared to 2024, mainly due to the completion of the funded research phase with Indivior.
Increased Net Loss from Neurosterix
Share of net loss from 20% participation in Neurosterix Group increased by CHF 0.7 million, amounting to CHF 1.2 million for Q2 2025.
Limited Cash for Unpartnered Programs
Current cash does not fund the progression of unpartnered programs into the clinic.
Company Guidance
In the Addex Therapeutics Half Year 2025 Financial Results call, the company reported substantial progress in its GABAB PAM program, particularly highlighting the completion of IND-enabling studies in partnership with Indivior for a substance use disorders drug candidate. Under this agreement, Addex is eligible for up to USD 330 million in payments upon achieving specific milestones, alongside tiered royalties. They also regained rights to their mGlu2 positive allosteric modulator program from Johnson & Johnson and are exploring new therapeutic indications. Financially, Addex ended the first half of 2025 with CHF 2.3 million in cash, projecting a runway through mid-2026, although this does not cover advancing unpartnered programs into the clinic. Their R&D expenses decreased to CHF 0.2 million, reflecting the completion of certain research phases. Addex is also advancing its independent GABAB PAM program for chronic cough, with preclinical studies showing promising efficacy and tolerability. The company is actively seeking financing to initiate IND-enabling studies for this program.

Addex Therapeutics Financial Statement Overview

Summary
Addex Therapeutics faces significant financial challenges, with negative profitability and cash flow issues. Despite a strong equity position and low leverage, the company struggles with persistent losses and cash flow difficulties, typical of early-stage biotech firms.
Income Statement
25
Negative
Addex Therapeutics has faced significant challenges in its income statement, with consistently negative gross profit margins and net income over the years. The company also shows a declining revenue trend, with revenue decreasing from 2020 to 2024. The gross profit margin and net profit margin are negative, indicating that the company is struggling to manage costs relative to its revenue, which is common in early-stage biotechnology companies.
Balance Sheet
55
Neutral
The balance sheet reflects a relatively strong equity position with a high equity ratio. The debt-to-equity ratio is low, indicating limited leverage, which is a positive sign of financial stability. However, the company has experienced a decrease in total assets over the years, and stockholders' equity has fluctuated, reflecting volatility in its financial position.
Cash Flow
30
Negative
Addex Therapeutics has experienced persistent negative free cash flow, indicating challenges in generating cash from operations. Although there was a decrease in negative operating cash flow in 2024, the company continues to rely on external financing. The free cash flow to net income ratio is unfavorable, highlighting ongoing cash flow challenges.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue91.72K404.10K1.61M1.42M2.92M3.61M
Gross Profit-142.73K404.10K1.61M1.42M2.92M3.61M
EBITDA-6.06M-4.65M-2.19M-10.45M-14.94M-12.41M
Net Income-6.05M7.06M-10.56M-20.80M-15.35M-12.86M
Balance Sheet
Total Assets8.51M10.68M4.64M8.28M22.54M20.18M
Cash, Cash Equivalents and Short-Term Investments2.30M3.35M3.87M6.96M20.50M18.76M
Total Debt38.39K41.99K344.34K373.13K482.01K567.40K
Total Liabilities1.29M1.00M3.50M3.37M5.61M5.57M
Stockholders Equity7.21M9.68M1.15M4.91M16.93M14.61M
Cash Flow
Free Cash Flow-1.44M-5.37M-8.00M-16.44M-14.74M-12.24M
Operating Cash Flow-1.44M-5.37M-7.99M-16.44M-14.71M-12.18M
Investing Cash Flow-759.10K4.65M-6.84K2.97K-30.31K-59.41K
Financing Cash Flow744.97K104.92K5.26M3.10M16.40M46.40K

Addex Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price10.95
Price Trends
50DMA
9.09
Negative
100DMA
8.76
Negative
200DMA
8.30
Positive
Market Momentum
MACD
-0.11
Positive
RSI
45.09
Neutral
STOCH
5.55
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ADXN, the sentiment is Negative. The current price of 10.95 is above the 20-day moving average (MA) of 9.15, above the 50-day MA of 9.09, and above the 200-day MA of 8.30, indicating a neutral trend. The MACD of -0.11 indicates Positive momentum. The RSI at 45.09 is Neutral, neither overbought nor oversold. The STOCH value of 5.55 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ADXN.

Addex Therapeutics Risk Analysis

Addex Therapeutics disclosed 54 risk factors in its most recent earnings report. Addex Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Addex Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
56
Neutral
$8.14M-0.72-32.58%-100.00%-463.97%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
$10.86M-61.65%-80.31%-293.92%
43
Neutral
$6.49M-1.43-51.83%-2.94%34.52%
38
Underperform
$6.50M-78.77%61.32%
28
Underperform
$6.93M>-0.01-563.25%80.34%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ADXN
Addex Therapeutics
8.52
-2.26
-20.96%
KPRX
Kiora Pharmaceuticals
2.33
-1.41
-37.70%
XBIO
Xenetic Biosciences
2.65
-1.30
-32.91%
NCNA
Nucana
3.67
-308.33
-98.82%
CELZ
Creative Medical Technology Holdings
3.28
0.38
13.10%
HCWB
HCW Biologics
3.06
-11.35
-78.76%

Addex Therapeutics Corporate Events

Addex Therapeutics Earnings Call: Strategic Gains Amid Challenges
Oct 10, 2025

The recent earnings call for Addex Therapeutics Ltd (ADR) presented a balanced sentiment, highlighting both significant achievements and notable challenges. The company showcased its progress in strategic partnerships and financial stability, while also addressing decreased income and increased net loss from associated ventures. The call also pointed out the limited cash available for unpartnered programs, painting a comprehensive picture of the company’s current standing.

Addex Therapeutics Reports Significant Loss Amid Financial Challenges
Oct 2, 2025

Addex Therapeutics Ltd is a clinical-stage biopharmaceutical company based in Switzerland, focusing on developing novel small molecule allosteric modulators for neurological disorders. The company operates in the pharmaceutical industry and is known for its innovative approach to drug discovery and development. In its latest half-year interim report for 2025, Addex Therapeutics reported a significant net loss, highlighting the financial challenges it faces. The company recorded a net loss of CHF 3.3 million for the first half of 2025, compared to a net profit of CHF 9.8 million in the same period of 2024, primarily due to the absence of revenue from contracts with customers and increased operating costs. The report also noted a decrease in cash and cash equivalents, which stood at CHF 2.3 million as of June 30, 2025, down from CHF 3.3 million at the end of 2024. Despite these challenges, Addex Therapeutics continues to focus on its core research and development activities, with operating costs primarily driven by these efforts. The company’s management remains committed to securing additional funding to support its operations and future growth. Looking ahead, Addex Therapeutics aims to continue its strategic focus on developing its portfolio of allosteric modulators, while actively seeking collaborations and partnerships to enhance its financial stability and operational capabilities.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 08, 2025