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Plus Therapeutics Inc (PSTV)
NASDAQ:PSTV
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Plus Therapeutics (PSTV) AI Stock Analysis

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PSTV

Plus Therapeutics

(NASDAQ:PSTV)

Rating:48Neutral
Price Target:
$0.50
▲(2.04% Upside)
The overall score reflects significant financial challenges and valuation concerns, partially offset by strategic corporate actions to improve compliance and financial flexibility. Technical indicators are mixed, suggesting cautious optimism.
Positive Factors
Clinical Progress
The ReSPECT-GBM trial reports positive results, with a median overall survival of 11 months, exceeding the standard of care.
Financial Position
The company has a solid balance sheet with $10 million in cash and no debt, and it raised $18 million in Q1, providing enough financial resources into 2026.
Product Launch
The upcoming launch of the CNSide platform, a novel diagnostic tool for leptomeningeal metastases, is expected to be a major positive for the stock.
Negative Factors
Operational Costs
An agreement with an investor for the purchase of up to 17 million shares of stock would help the company cover operational costs associated with the launch of CNSide.
Revenue Performance
The company reported $1.0M in grant revenues in 1Q25, compared to consensus estimated revenue of $1.5M, and a net loss of $1.19 per share, compared to consensus estimated net loss of $0.25 per share.

Plus Therapeutics (PSTV) vs. SPDR S&P 500 ETF (SPY)

Plus Therapeutics Business Overview & Revenue Model

Company DescriptionPlus Therapeutics, Inc. (PSTV) is a clinical-stage biotechnology company focused on developing innovative therapies for cancer and other serious diseases. The company is primarily engaged in the development of its lead product candidate, Rhenium-186 NanoLiposome, which is designed for the targeted treatment of brain cancer and other tumors. Plus Therapeutics operates in the biopharmaceutical sector, aiming to provide advanced treatment options that enhance patient outcomes through novel delivery mechanisms and formulations.
How the Company Makes MoneyPlus Therapeutics generates revenue primarily through the development and commercialization of its therapeutic candidates. The company may receive funding through various means, including government grants, partnerships with larger pharmaceutical companies, and strategic collaborations that provide upfront payments, milestone payments, and royalties on future sales. Additionally, if its product candidates receive regulatory approval and enter the market, PSTV could realize significant revenue from product sales. The company is also exploring opportunities for licensing agreements, which could provide additional revenue streams by allowing other companies to commercialize its technologies in specific markets.

Plus Therapeutics Earnings Call Summary

Earnings Call Date:Aug 14, 2025
(Q4-2024)
|
% Change Since: |
Next Earnings Date:Oct 16, 2025
Earnings Call Sentiment Positive
The earnings call presented a mix of promising clinical trial results, successful financing, and strategic acquisitions that position Plus Therapeutics for future growth. However, these positives were offset by an increase in operating loss and a decline in cash reserves. The overall sentiment leans towards optimism due to strong forward-looking developments.
Q4-2024 Updates
Positive Updates
Successful Financing and Partnerships
Plus Therapeutics raised $15 million in an underwritten equity financing and received $2 million in accelerated grant proceeds from CPRIT. This strengthens the balance sheet and provides funding through mid-2026. Partnerships with SpectronRX, IsoTherapeutics, RadioMedix, and ABX were also announced to ensure supply chain management for REYOBIQ.
FDA Approvals and Designations
The company received FDA approval for orphan designation of REYOBIQ for LM due to lung cancer, adding to previous orphan and fast-track designations for breast cancer.
Positive Clinical Trial Results
ReSPECT-LM Phase 1 trial showed promising safety and efficacy data, with a recommended Phase 2 dose of 44 millicuries. Results indicated a median overall survival of nine months, compared to the historical four months.
CNSide Platform Acquisition and Launch
Plus Therapeutics acquired CNSide, a CNS cancer testing platform, to increase the market potential of REYOBIQ by 2-4 times. The assay is set to launch commercially this year, starting with a limited geographic introduction.
Negative Updates
Operating Loss Increase
The company reported an operating loss of $14.7 million in 2024, up from $13.3 million in 2023, primarily due to increased spending related to the ReSPECT-LM trial.
Cash and Investment Decline
Cash and investments decreased to $3.6 million at the end of 2024 from $8.6 million at the end of 2023.
Company Guidance
In the recent Plus Therapeutics' Fourth Quarter and Full Year 2024 Results Conference Call, the company provided extensive guidance on its financial and clinical milestones. The company completed a $15 million equity financing and received $2 million in accelerated grant proceeds from CPRIT, securing funding through mid-2026. Key clinical updates included the completion of the ReSPECT-LM Phase 1 trial, establishing a recommended Phase 2 dose of 44 millicuries for their lead drug REYOBIQ, which showed promising safety and efficacy data. Plus Therapeutics plans to conduct an end-of-Phase 1 meeting with the FDA to finalize the path to approval, especially for LM related to breast cancer. Additionally, the company aims to advance its CNSide diagnostics platform, projecting significant market potential and a planned full launch within the year. Financially, the company reported a net loss of $13 million for 2024, compared to $13.3 million in 2023, and highlighted an expected 2025 grant revenue of $6 to $8 million.

Plus Therapeutics Financial Statement Overview

Summary
Plus Therapeutics is in a challenging financial position with consistent losses, negative equity, and cash flow difficulties. The financial health of the company suggests significant risks and a need for strategic restructuring to improve its financial trajectory.
Income Statement
25
Negative
Plus Therapeutics has faced significant challenges with no revenue reported in the most recent year and consistent net losses over time. The company experienced severe negative EBIT and EBITDA margins. Revenue growth has been volatile and negative, reflecting instability in income generation.
Balance Sheet
20
Very Negative
The company's balance sheet reveals negative stockholders' equity, indicating potential financial distress. The debt-to-equity ratio cannot be computed meaningfully due to negative equity. Additionally, Plus Therapeutics has a high level of debt relative to its assets, posing potential solvency risks.
Cash Flow
30
Negative
Cash flow analysis shows persistent negative free cash flow, indicating challenges in generating cash from operations. The operating cash flow to net income ratio is negative, suggesting inefficiencies. Despite some financing inflows, the company struggles with cash flow sustainability.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue2.34M5.82M4.91M224.00K0.00303.00K
Gross Profit-616.00K4.97M-4.78M-488.00K-66.00K-2.40M
EBITDA-18.95M-8.40M-12.69M-18.85M-12.05M-6.76M
Net Income-27.12M-12.98M-13.32M-20.27M-13.40M-8.24M
Balance Sheet
Total Assets12.06M6.63M11.39M23.87M21.98M12.11M
Cash, Cash Equivalents and Short-Term Investments9.87M3.61M8.55M18.12M18.40M8.35M
Total Debt40.00K3.37M4.18M5.64M6.99M7.00M
Total Liabilities35.70M15.58M12.74M17.42M11.14M9.07M
Stockholders Equity-23.64M-8.95M-1.35M6.45M10.84M3.03M
Cash Flow
Free Cash Flow-12.87M-10.70M-13.01M-13.48M-10.42M-8.93M
Operating Cash Flow-12.21M-10.55M-12.85M-12.97M-10.28M-8.43M
Investing Cash Flow-189.00K-4.11M-160.00K-759.00K-82.00K-493.00K
Financing Cash Flow19.37M6.19M3.44M13.45M20.42M-319.00K

Plus Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.49
Price Trends
50DMA
0.45
Positive
100DMA
0.50
Negative
200DMA
0.82
Negative
Market Momentum
MACD
>-0.01
Positive
RSI
46.36
Neutral
STOCH
18.65
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PSTV, the sentiment is Negative. The current price of 0.49 is below the 20-day moving average (MA) of 0.60, above the 50-day MA of 0.45, and below the 200-day MA of 0.82, indicating a neutral trend. The MACD of >-0.01 indicates Positive momentum. The RSI at 46.36 is Neutral, neither overbought nor oversold. The STOCH value of 18.65 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PSTV.

Plus Therapeutics Risk Analysis

Plus Therapeutics disclosed 54 risk factors in its most recent earnings report. Plus Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Plus Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.83B-0.18-40.10%2.29%21.46%-2.03%
51
Neutral
$13.29M0.68-162.42%-82.24%
48
Neutral
$50.15M249.03%-3.49%27.88%
$11.43M-2264.31%
42
Neutral
$1.52K
-95.23%42.16%
34
Underperform
$16.45M1.60>-0.01%
34
Underperform
$19.85M-9690.24%1943.07%80.97%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PSTV
Plus Therapeutics
0.49
-0.93
-65.49%
ERNA
Eterna Therapeutics
1.39
-26.06
-94.94%
NERV
Minerva Neurosciences
2.37
-0.43
-15.36%
AFMDQ
Affimed
0.02
-4.40
-99.55%
GOVX
GeoVax Labs
0.76
-4.19
-84.65%
ADXN
Addex Therapeutics
7.91
-2.32
-22.68%

Plus Therapeutics Corporate Events

Delistings and Listing ChangesRegulatory Filings and Compliance
Plus Therapeutics Secures Nasdaq Compliance Extension
Neutral
Aug 26, 2025

On August 22, 2025, Plus Therapeutics, Inc. received confirmation from Nasdaq that it complies with Nasdaq Listing Rule 5550(b), meeting both the Market Value of Listing Securities standard and the alternative stockholders’ equity threshold. This compliance allows the company to extend its grace period to meet the $1.00 bid price rule until November 12, 2025. However, the company is subject to a one-year monitoring period regarding the Equity Standard. If it fails to maintain compliance within this period, Nasdaq will issue a delist determination letter, though the company can request a hearing to potentially stay further actions.

Delistings and Listing ChangesRegulatory Filings and Compliance
Plus Therapeutics Awaits Nasdaq Compliance Confirmation
Positive
Aug 14, 2025

On June 3, 2025, Plus Therapeutics was notified by Nasdaq that it failed to meet the minimum stockholders’ equity requirement of $2.5 million, leading to a delist determination. However, after a hearing on July 15, 2025, the company was granted an extension to comply with the rule. By June 30, 2025, Plus Therapeutics reported stockholders’ equity of $3 million and continued to maintain compliance by selling over $2 million in common stock. The company also reported a market value of listed securities of at least $35 million for 20 consecutive business days as of August 13, 2025, meeting an alternative compliance threshold. Plus Therapeutics is awaiting Nasdaq’s confirmation of compliance with either the equity rule or the alternative market value requirement.

Delistings and Listing ChangesRegulatory Filings and Compliance
Plus Therapeutics Granted Continued Nasdaq Listing
Neutral
Aug 13, 2025

On June 3, 2025, Plus Therapeutics was notified by the Nasdaq Listing Qualifications Department that it failed to meet the minimum stockholders’ equity requirement of $2.5 million, with a reported deficit of $23,641,000 as of March 31, 2025. Consequently, Nasdaq planned to delist the company’s securities unless an appeal was made. Following a hearing on July 15, 2025, the company was granted continued listing on July 22, 2025, provided it meets specific conditions by August 14, 2025, and September 8, 2025, including maintaining a minimum stock price and demonstrating compliance with equity requirements.

Executive/Board ChangesPrivate Placements and FinancingShareholder MeetingsStock SplitBusiness Operations and Strategy
Plus Therapeutics Approves Key Proposals at Annual Meeting
Positive
Aug 12, 2025

On August 7, 2025, Plus Therapeutics held its Annual Meeting of Stockholders where five key proposals were voted on. The stockholders elected directors to the board, approved the potential issuance of up to $51 million in common stock to Lincoln Park Capital Fund, and granted the board authority for a reverse stock split. Additionally, the compensation of named executive officers and amendments to the 2020 Stock Incentive Plan were approved. These decisions reflect strategic moves to strengthen the company’s financial position and operational flexibility.

Private Placements and FinancingBusiness Operations and Strategy
Plus Therapeutics Enters Purchase Agreement with Lincoln Park
Neutral
Jun 20, 2025

Plus Therapeutics has entered into a Purchase Agreement with Lincoln Park, which is an accredited investor, to issue and sell securities under exemptions from the registration requirements of the Securities Act. This strategic move allows Plus Therapeutics to raise capital while leveraging regulatory exemptions, potentially impacting its financial strategy and stakeholder interests.

Private Placements and FinancingBusiness Operations and Strategy
Plus Therapeutics Modifies Security Holders’ Rights
Neutral
Jun 17, 2025

On March 4, 2025, Plus Therapeutics, Inc. entered into a Securities Purchase Agreement with various purchasers, resulting in a private placement involving shares and warrants of the company’s common stock. On June 17, 2025, the company and the purchasers agreed to a letter agreement to minimize the dilutive impact of the private placement. This included the cancellation of Series A Warrants, amendment of Series B Warrants, waiver of the Registration Rights Agreement, and the return of certain shares and warrants by the purchasers. These actions are aimed at reducing the potential negative impact on the company’s stockholders’ equity and facilitating future capital raising efforts.

Delistings and Listing ChangesRegulatory Filings and Compliance
Plus Therapeutics Appeals Nasdaq Delisting Decision
Negative
Jun 6, 2025

On June 3, 2025, Plus Therapeutics, Inc. received a letter from Nasdaq stating that the company had regained compliance with Rule 5250(c)(1) after filing its Quarterly Report for the period ended March 31, 2025. However, the company was notified of non-compliance with the Minimum Stockholders’ Equity Requirement, leading to a decision to delist its securities unless an appeal is made. Plus Therapeutics plans to request a hearing to appeal this decision, during which its stock will continue trading on the Nasdaq Capital Market.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 19, 2025