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Plus Therapeutics (PSTV)
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Plus Therapeutics (PSTV) AI Stock Analysis

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Plus Therapeutics

(NASDAQ:PSTV)

Rating:40Underperform
Price Target:
$0.50
▲(56.25%Upside)
The overall stock score of 40 reflects significant financial difficulties and critical corporate events impacting Plus Therapeutics. Notably, the company's negative equity and cash flow issues, compounded by Nasdaq delisting challenges, present substantial risks. Technical analysis shows bearish trends, further weighing on the stock's outlook.
Positive Factors
Analyst Rating
Analyst maintains a BUY rating and raises the 12-month price target to $20.50, indicating a belief in significant upside potential due to Plus Therapeutics' clinical progress and market opportunities.
Diagnostic Commercialization
The upcoming launch of the CNSide platform, a novel diagnostic tool for leptomeningeal metastases, is expected to be a major positive for the stock.
Financial Stability
The company has a solid balance sheet with $10 million in cash and no debt, and it raised $18 million in Q1, providing enough financial resources into 2026.
Negative Factors
Financial Performance
The company reported $1.0M in grant revenues in 1Q25, compared to consensus estimated revenue of $1.5M, and a net loss of $1.19 per share, compared to consensus estimated net loss of $0.25 per share.
Stock Dilution
Lowering the 12-month price target to $5.50 per share from $8.00 to account for the increased number of outstanding shares and warrants.

Plus Therapeutics (PSTV) vs. SPDR S&P 500 ETF (SPY)

Plus Therapeutics Business Overview & Revenue Model

Company DescriptionPlus Therapeutics, Inc., a clinical-stage pharmaceutical company, focuses on the development, manufacture, and commercialization of treatments for patients with cancer and other diseases. Its lead drug candidate is Rhenium-186 NanoLiposome, a patented radiotherapy that targets central nervous system cancers, including recurrent glioblastoma, leptomeningeal metastases, and pediatric brain cancers. It has a license agreement with NanoTx, Corp. to develop and commercialize NanoTx's glioblastoma treatment. The company was formerly known as Cytori Therapeutics, Inc. and changed its name to Plus Therapeutics, Inc. in July 2019. Plus Therapeutics, Inc. was founded in 1996 and is headquartered in Austin, Texas.
How the Company Makes MoneyPlus Therapeutics primarily generates revenue through the development and commercialization of its proprietary radiotherapeutic products. The company is focused on advancing its lead product candidates through clinical trials, seeking regulatory approvals, and eventually bringing these therapies to market. Additionally, Plus Therapeutics may engage in strategic partnerships and collaborations with other biotechnology companies, research institutions, or pharmaceutical firms to co-develop products or license its technology. These partnerships can provide milestone payments, royalties, or other forms of revenue sharing that contribute to the company's financial growth. Government grants and funding for research and development initiatives may also play a role in supporting its operational and clinical activities.

Plus Therapeutics Earnings Call Summary

Earnings Call Date:May 30, 2025
(Q4-2024)
|
% Change Since: 10.34%|
Next Earnings Date:Aug 18, 2025
Earnings Call Sentiment Positive
The earnings call presented a mix of promising clinical trial results, successful financing, and strategic acquisitions that position Plus Therapeutics for future growth. However, these positives were offset by an increase in operating loss and a decline in cash reserves. The overall sentiment leans towards optimism due to strong forward-looking developments.
Q4-2024 Updates
Positive Updates
Successful Financing and Partnerships
Plus Therapeutics raised $15 million in an underwritten equity financing and received $2 million in accelerated grant proceeds from CPRIT. This strengthens the balance sheet and provides funding through mid-2026. Partnerships with SpectronRX, IsoTherapeutics, RadioMedix, and ABX were also announced to ensure supply chain management for REYOBIQ.
FDA Approvals and Designations
The company received FDA approval for orphan designation of REYOBIQ for LM due to lung cancer, adding to previous orphan and fast-track designations for breast cancer.
Positive Clinical Trial Results
ReSPECT-LM Phase 1 trial showed promising safety and efficacy data, with a recommended Phase 2 dose of 44 millicuries. Results indicated a median overall survival of nine months, compared to the historical four months.
CNSide Platform Acquisition and Launch
Plus Therapeutics acquired CNSide, a CNS cancer testing platform, to increase the market potential of REYOBIQ by 2-4 times. The assay is set to launch commercially this year, starting with a limited geographic introduction.
Negative Updates
Operating Loss Increase
The company reported an operating loss of $14.7 million in 2024, up from $13.3 million in 2023, primarily due to increased spending related to the ReSPECT-LM trial.
Cash and Investment Decline
Cash and investments decreased to $3.6 million at the end of 2024 from $8.6 million at the end of 2023.
Company Guidance
In the recent Plus Therapeutics' Fourth Quarter and Full Year 2024 Results Conference Call, the company provided extensive guidance on its financial and clinical milestones. The company completed a $15 million equity financing and received $2 million in accelerated grant proceeds from CPRIT, securing funding through mid-2026. Key clinical updates included the completion of the ReSPECT-LM Phase 1 trial, establishing a recommended Phase 2 dose of 44 millicuries for their lead drug REYOBIQ, which showed promising safety and efficacy data. Plus Therapeutics plans to conduct an end-of-Phase 1 meeting with the FDA to finalize the path to approval, especially for LM related to breast cancer. Additionally, the company aims to advance its CNSide diagnostics platform, projecting significant market potential and a planned full launch within the year. Financially, the company reported a net loss of $13 million for 2024, compared to $13.3 million in 2023, and highlighted an expected 2025 grant revenue of $6 to $8 million.

Plus Therapeutics Financial Statement Overview

Summary
Plus Therapeutics is in a challenging financial position with consistent losses, negative equity, and cash flow difficulties. The company's financial health suggests significant risks and a need for strategic restructuring to improve its financial trajectory.
Income Statement
25
Negative
Plus Therapeutics has faced significant challenges with no revenue reported in the most recent year and consistent net losses over time. The company experienced severe negative EBIT and EBITDA margins. Revenue growth has been volatile and negative, reflecting instability in income generation.
Balance Sheet
20
Very Negative
The company's balance sheet reveals negative stockholders' equity, indicating potential financial distress. The debt-to-equity ratio cannot be computed meaningfully due to negative equity. Additionally, Plus Therapeutics has a high level of debt relative to its assets, posing potential solvency risks.
Cash Flow
30
Negative
Cash flow analysis shows persistent negative free cash flow, indicating challenges in generating cash from operations. The operating cash flow to net income ratio is negative, suggesting inefficiencies. Despite some financing inflows, the company struggles with cash flow sustainability.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue5.82M4.91M224.00K0.00303.00K
Gross Profit4.97M-4.78M-488.00K-66.00K-2.40M
EBITDA-8.40M-12.69M-18.85M-12.05M-6.76M
Net Income-12.98M-13.32M-20.27M-13.40M-8.24M
Balance Sheet
Total Assets6.63M11.39M23.87M21.98M12.11M
Cash, Cash Equivalents and Short-Term Investments3.61M8.55M18.12M18.40M8.35M
Total Debt3.37M4.18M5.64M6.99M7.00M
Total Liabilities15.58M12.74M17.42M11.14M9.07M
Stockholders Equity-8.95M-1.35M6.45M10.84M3.03M
Cash Flow
Free Cash Flow-11.24M-13.01M-13.48M-10.42M-8.93M
Operating Cash Flow-10.55M-12.85M-12.97M-10.28M-8.43M
Investing Cash Flow-4.11M-160.00K-759.00K-82.00K-493.00K
Financing Cash Flow6.19M3.44M13.45M20.42M-319.00K

Plus Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.32
Price Trends
50DMA
0.37
Negative
100DMA
0.63
Negative
200DMA
0.95
Negative
Market Momentum
MACD
>-0.01
Negative
RSI
47.52
Neutral
STOCH
51.52
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PSTV, the sentiment is Negative. The current price of 0.32 is above the 20-day moving average (MA) of 0.30, below the 50-day MA of 0.37, and below the 200-day MA of 0.95, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 47.52 is Neutral, neither overbought nor oversold. The STOCH value of 51.52 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PSTV.

Plus Therapeutics Risk Analysis

Plus Therapeutics disclosed 54 risk factors in its most recent earnings report. Plus Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Plus Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (52)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$13.62M0.78-162.42%-82.24%
52
Neutral
$7.39B>-0.01-63.86%2.36%16.15%0.36%
40
Underperform
$19.18M249.03%-14.43%16.04%
$14.13M-2264.31%
42
Neutral
$593.87K
-95.23%-325.89%
34
Underperform
$12.68M2.55>-0.01%
34
Underperform
$17.36M-616.17%71.39%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PSTV
Plus Therapeutics
0.32
-1.41
-81.50%
ERNA
Eterna Therapeutics
1.97
-29.98
-93.83%
NERV
Minerva Neurosciences
2.10
-1.12
-34.78%
AFMDQ
Affimed
0.03
-5.41
-99.45%
GOVX
GeoVax Labs
0.73
-2.19
-75.00%
ADXN
Addex Therapeutics
8.83
0.82
10.24%

Plus Therapeutics Corporate Events

Private Placements and FinancingBusiness Operations and Strategy
Plus Therapeutics Enters Purchase Agreement with Lincoln Park
Neutral
Jun 20, 2025

Plus Therapeutics has entered into a Purchase Agreement with Lincoln Park, which is an accredited investor, to issue and sell securities under exemptions from the registration requirements of the Securities Act. This strategic move allows Plus Therapeutics to raise capital while leveraging regulatory exemptions, potentially impacting its financial strategy and stakeholder interests.

The most recent analyst rating on (PSTV) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Plus Therapeutics stock, see the PSTV Stock Forecast page.

Private Placements and FinancingBusiness Operations and Strategy
Plus Therapeutics Modifies Security Holders’ Rights
Neutral
Jun 17, 2025

On March 4, 2025, Plus Therapeutics, Inc. entered into a Securities Purchase Agreement with various purchasers, resulting in a private placement involving shares and warrants of the company’s common stock. On June 17, 2025, the company and the purchasers agreed to a letter agreement to minimize the dilutive impact of the private placement. This included the cancellation of Series A Warrants, amendment of Series B Warrants, waiver of the Registration Rights Agreement, and the return of certain shares and warrants by the purchasers. These actions are aimed at reducing the potential negative impact on the company’s stockholders’ equity and facilitating future capital raising efforts.

The most recent analyst rating on (PSTV) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Plus Therapeutics stock, see the PSTV Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Plus Therapeutics Appeals Nasdaq Delisting Decision
Negative
Jun 6, 2025

On June 3, 2025, Plus Therapeutics, Inc. received a letter from Nasdaq stating that the company had regained compliance with Rule 5250(c)(1) after filing its Quarterly Report for the period ended March 31, 2025. However, the company was notified of non-compliance with the Minimum Stockholders’ Equity Requirement, leading to a decision to delist its securities unless an appeal is made. Plus Therapeutics plans to request a hearing to appeal this decision, during which its stock will continue trading on the Nasdaq Capital Market.

The most recent analyst rating on (PSTV) stock is a Buy with a $4.00 price target. To see the full list of analyst forecasts on Plus Therapeutics stock, see the PSTV Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Plus Therapeutics Faces Nasdaq Compliance Notice
Neutral
May 23, 2025

On May 21, 2025, Plus Therapeutics received a notice from Nasdaq due to a delay in filing its Quarterly Report for the period ending March 31, 2025, which resulted in non-compliance with Nasdaq Listing Rule 5250(c)(1). The company has until July 21, 2025, to submit a compliance plan, with a possible extension until November 17, 2025, if accepted. This notification does not immediately affect the company’s Nasdaq listing, and Plus Therapeutics is working to file the report promptly to regain compliance.

The most recent analyst rating on (PSTV) stock is a Buy with a $32.00 price target. To see the full list of analyst forecasts on Plus Therapeutics stock, see the PSTV Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Plus Therapeutics Receives Nasdaq Delisting Notice
Negative
May 19, 2025

On May 16, 2025, Plus Therapeutics, Inc. received a notice from Nasdaq indicating that its common stock had fallen below the minimum bid price requirement of $1.00 per share for 30 consecutive business days. This situation does not immediately affect the company’s stock listing or trading, but Plus Therapeutics has until November 12, 2025, to regain compliance by maintaining a closing bid price of at least $1.00 per share for 10 consecutive business days. If compliance is not achieved by this date, the company may qualify for an additional 180-day period to meet the requirement, potentially through measures like a reverse stock split. Failure to comply could result in delisting, although the company can appeal such a decision.

The most recent analyst rating on (PSTV) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Plus Therapeutics stock, see the PSTV Stock Forecast page.

Executive/Board Changes
Plus Therapeutics Appoints Kyle Guse to Board
Neutral
Apr 18, 2025

On April 18, 2025, Plus Therapeutics, Inc. appointed Mr. Kyle Guse to its Board of Directors, filling the vacancy left by Mr. Greg Petersen’s resignation. Mr. Guse, who has extensive experience in finance, corporate governance, and law, will also serve on the Audit and Compensation Committees, and as Chairman of the Audit Committee. His appointment is seen as a strategic move to strengthen the company’s governance and financial oversight.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 16, 2025