Quarterly Financial Beat and Guidance Raise
Adjusted EPS of $2.65, $0.07 above guidance midpoint; total net revenues of $15.0 billion, beating expectations by ~$300 million and representing 12.4% sales growth. Company raised full-year adjusted EPS guidance by $0.12 to $14.08–$14.28 and increased full-year revenue outlook to approximately $67.3 billion (+$300 million).
Strong Immunology Performance (Skyrizi & Rinvoq)
Immunology revenues $7.3 billion, +$1.0 billion year-over-year. Skyrizi sales $4.5 billion, up 29.2% (operational). Rinvoq sales $2.1 billion, up 20.2% (operational). Skyrizi showing share gains across psoriasis, psoriatic arthritis and IBD; Skyrizi on track for >30% global sales growth in IBD this year.
Neuroscience Momentum
Neuroscience revenues nearly $2.9 billion, up 24.3% (operational). Vraylar $905 million, +18.4%; VYALEV $201 million, ~+10% sequential. Company preparing for potential U.S. approval and launch of tavapadon in Parkinson's later this year.
Selected Product Strengths and Category Leadership
Botox Therapeutic and other migraine portfolio delivering robust double-digit growth; Botox Cosmetic $668 million (+17%); Skyrizi demonstrated long-term radiographic data in psoriatic arthritis (nearly 90% no radiographic progression at 5 years) and new label additions for hard-to-treat psoriasis areas.
Pipeline Progress — Regulatory Submissions & Positive Readouts
U.S. submission of Rinvoq for alopecia areata; U.S. submission for Skyrizi subcutaneous induction in Crohn's with approval decision expected later this year; interim combination data (Skyrizi + ABBV-382) showing potential transformational efficacy in Crohn's.
Promising Early Obesity Data (ABBV-295)
Multiple-ascending-dose study of long-acting amylin analog ABBV-295 showed nearly 10% weight loss in 12 weeks in a predominantly male, nonobese cohort with favorable tolerability; half-life ~270 hours and potential for every-other-week or monthly dosing in future development.
Oncology Pipeline Actions & External BD
Expanded oncology assets via Remagen agreement for a PD-1/VEGF bispecific; Temab-A strategy shift to combination (Temab-A + bevacizumab) in all-comers colorectal cancer with reported ORR ~30% and disease control rate ~97% in early data; multiple ASCO readouts and acceleration discussions planned.
Capital Investment & Manufacturing Commitment
Announced part of $100 billion U.S. R&D and capital investment commitment: $1.4 billion pharmaceutical campus in North Carolina and $380 million for two plants in North Chicago to expand manufacturing capacity.
Strong Profitability and Margin Targets
Reported adjusted gross margin 83.6% of sales; adjusted operating margin 40.8% in Q1 (includes acquired IPR&D impact). Full-year targets include adjusted gross margin above 84% and an adjusted operating margin ratio of ~47.5%.
Financial Flexibility & Capital Allocation
Adjusted net interest expense guidance reduced to ~$2.7 billion (improvement of ~$100 million). Company reiterates commitment to record investment in the business, active BD, and returning capital through a growing dividend.