Prescription Volume and Quarter-over-Quarter Growth
Approximately 25,000 paid and billed prescriptions in Q1 2026, a 19% increase versus Q4 2025; total filled/shipments since launch of roughly 46,000 boxes/units.
Net Revenue and Revenue Mix
Q1 net revenue of ~$1.9 million, including ~$1.7 million in product sales and $0.25 million in license revenue from an ex-U.S. distribution deal.
Strong Prescriber Base and Productivity Signal
Over 10,000 unique prescribers through the first quarter; prescribing physicians are more productive—at a comparable launch stage the product is generating ~70% more scripts per prescriber than Vuity; ~60% of prescribing ECPs have written multiple times.
E-pharmacy and Early Persistence
E-pharmacy represents more than half of prescriptions; over two-thirds of e-pharmacy volume now comes from three-month prescriptions (meaningful increase from Q4 to Q1), indicating early refill/persistence behavior.
Unit Economics and Margins
Blended gross-to-net discounts across channels under 10%; net revenue per monthly pack approximately $67 and net cash per unit after distribution channel costs about $60; management expects ~90% direct product gross margin over time.
Commercial Execution and Field Expansion
Field organization expansion to reach ~15,000 targeted eye care professionals by end of the quarter; targeted commercial actions include QR-based onboarding tools, physician selling where permitted, refined exam-room messaging, and DTC optimizations including initial linear TV pilots.
Safety and Real-World Tolerability
Market exposure of ~1.2 million doses (≈46,000 boxes shipped) with safety profile consistent with clinical program: zero retinal detachments and two retinal tears (both with preexisting risk factors and assessed as likely noncausal); management reports no mechanistic retina signal to date and favorable comparison to reported events for a competitor at similar exposure.
Manufacturing and Product Experience Improvements
Transition to an FDA-approved large-scale manufacturing process with tighter formulation specification and enhanced vial format planned to improve ease of use, comfort, and direct-to-customer experience.
Strong Cash Position and Planned OpEx Focus
Cash, cash equivalents and marketable securities of ~$258.4 million at quarter end; Q1 net cash burn of ~$34 million, consistent with Q4 and in line with budget; R&D spend reduced to $0 as focus shifts to SG&A and commercial execution.
High Physician Awareness and Market Interest
ECP aided awareness in the high 90s and unaided awareness over 80%; growing inbound partnering interest and regulatory submissions in Europe and the U.K., with existing partnerships in China, Southeast Asia, Canada, and the Middle East.