Strong Full-Year and Q4 Revenue
Full-year 2025 worldwide sales of $94.2 billion, up 5.3% operationally; Q4 2025 sales of $24.6 billion, up 7.1% operationally despite a ~650 basis point headwind from STELARA.
Adjusted Earnings and EPS Growth
Full-year adjusted net earnings of $26.2 billion and adjusted diluted EPS of $10.79, up 8.1% year-over-year; Q4 adjusted diluted EPS of $2.46, up 21.5% versus prior year.
Robust Free Cash Flow and Balance Sheet Strength
Generated $19.7 billion of free cash flow in 2025; ended the year with ~$20 billion in cash and marketable securities and net debt of ~$28 billion; company expects free cash flow of ~ $21 billion in 2026.
Innovation and Pipeline Momentum
In 2025 J&J secured 51 approvals, filed 32 submissions across major markets, delivered positive readouts from 17 key studies, and initiated 11 new Phase III programs — signaling substantial R&D productivity.
Oncology Outperformance
Oncology delivered ~21% operational sales growth in 2025; DARZALEX is the largest pharma product with annual sales > $14 billion (full-year growth ~22–24%); CARVICTI treated >10,000 patients and Carvictee sales reached $555 million, up 63.2% in the quarter.
Immunology Momentum (Tremfya and Pipeline)
Tremfya full-year sales accelerated to > $5 billion and Q4 growth of ~65.4% (quarter), becoming the fastest-growing IL-23 therapy; company projects Tremfya could exceed $10 billion in peak sales and expects approval/launch of oral icotide in 2026.
Neuroscience and New Launches
Spravato continued strong growth (year-over-year growth cited at 57%–67.8% depending on period) with >200,000 patients treated worldwide; CAPLYTA launched in the US for adjunctive major depressive disorder and is viewed as a ~$5 billion peak year opportunity.
MedTech Growth and Product Momentum
MedTech sales of $8.8 billion in the quarter increased 5.8% operationally; cardiovascular grew ~15% for the year with Abiomed (18.3% growth) and Shockwave (22.9%); Surgery and Vision showed accelerating momentum with 15 major launches and >40 regulatory approvals in 2025.
2026 Guidance and Long-Term Outlook
Guidance for 2026 operational sales growth of 5.7%–6.7% (midpoint ~$100 billion / 6.2% operational), adjusted EPS growth of ~5.5% at midpoint, and management reiterates line of sight to double-digit revenue growth by the end of the decade.
Capital Allocation and Strategic Actions
Invested > $32 billion in R&D and M&A in 2025 (including Intracellular and Halda), started new manufacturing facilities in the U.S., and progressed a planned orthopedics separation targeted for mid-2027 to sharpen portfolio focus.