Quarterly Revenue Beat and Return to Growth
Q4 revenue of $1.16B came in above expectations (up 5% YoY reported, +4% constant currency). Illumina returned to full-year ex‑China growth of 2% in 2025 and reported ex‑China revenue growth of 7% in Q4.
Rapid Acceleration in Clinical Consumables
Clinical consumables grew 20% ex‑China in Q4 and roughly 16% ex‑China in H2 2025. Management expects continued robust clinical growth in 2026 (double‑digit to mid‑teens) driven by adoption of sequencing‑based diagnostics and higher sequencing intensity (e.g., shift toward whole genome).
Strong Sequencing Throughput and NovaSeq X Adoption
Total sequencing output (GB) on connected high and mid throughput instruments grew >30% YoY. Illumina placed over 100 NovaSeq X systems in Q4 (bringing active installed base to ~890); 55% of revenue had transitioned to NovaSeq X as of Q4. Instruments revenue was $154M (roughly flat YoY, +3% ex‑China).
Margin Expansion and EPS Growth
Non‑GAAP operating margin expanded materially (company cited +180 bps for the year; Q4 non‑GAAP operating margin 23.7%, +400 bps YoY). Non‑GAAP EPS was $1.35 in Q4 (+~42% YoY) and full‑year EPS was $4.84 (+16% YoY). Operating profit grew ~26% YoY in Q4.
Strong Cash Generation and Shareholder Returns
Operating cash flow was $321M in Q4 and $1.1B for the year. Free cash flow was ~$267M in Q4 and ~$931M for the year. The company returned approximately $740M to shareholders via repurchases in 2025 (Q4 repurchases ~$42M; $643M remaining buyback authorization).
Strategic Multiomics and Data Progress (Somalogic & BioInsight)
Closed Somalogic acquisition (upfront $350M) to add high‑throughput proteomics capability and accelerate multiomics. Launched BioInsight and the Billion Cell Atlas with early pharma collaborations (AstraZeneca, Merck, Eli Lilly), expanding addressable markets in drug discovery and data/AI products.
Constructive 2026 Financial Outlook
2026 guidance: revenue $4.5–4.6B (reported growth 4–6%; ex‑China organic growth 2–4%), operating margin 23.3–23.5%, and EPS $5.00–$5.20 (includes ~$0.18 Somalogic dilution; ~10% YoY EPS growth excluding dilution). Instrument placement target of ~50–60 NovaSeq X per quarter (~200–240/year).