Top-Line Beat and Raised Full-Year Guidance
Q1 revenue of $1.09 billion, up 4.8% year-over-year (1.2% organic); came in $20 million above the midpoint of guidance. Company raised 2026 revenue guidance by $20 million to $4.52B–$4.62B and nudged EPS and margin guidance higher.
Strong Sequencing Consumables and Clinical Demand
Sequencing consumables revenue of $726 million, up 4% YoY; Rest of World organic consumables growth ~5%. Clinical consumables grew ~20% ex-China for the second consecutive quarter and represented >65% of sequencing consumables revenue in Q1.
Robust NovaSeq X Placements and Installed-Base Transition
Over 80 NovaSeq X placements in Q1 (~20 more than Q1 2025). As of Q1 roughly 82% of volumes and 55% of revenue transitioned to NovaSeq X; 90% of research & applied volume and 76% of clinical volume now on X with target of 80–85% clinical on X by end of 2026.
Sequencing Throughput and Instrument Momentum
Total sequencing GB output on connected high- and mid-throughput instruments grew >30% YoY. Sequencing instruments revenue was $118 million, up 9% YoY (Rest of World organic instrument growth ~10%).
Margin and EPS Expansion
Non‑GAAP gross margin of 68.2% (up ~80 bps YoY). Non‑GAAP operating margin 21.9% (expanding ~150 bps YoY). Non‑GAAP diluted EPS of $1.15 in Q1, up ~19% YoY and ~$0.10 above guidance midpoint. Full-year operating margin guidance raised to 23.4%–23.6%.
Strong Cash Generation and Capital Allocation
Cash flow from operations $289 million; free cash flow $251 million in Q1. Repurchased 2 million shares for $242 million; board authorized an additional $1.5 billion share repurchase program. Ending cash and equivalents ~$1.16 billion; gross leverage ~1.5x gross debt to LTM EBITDA.
Strategic M&A and Product Innovation
Closed SomaLogic acquisition (net cash payment ~$363 million); business performing in line with expectations. Product and R&D progress: TruePath launch (WGS with ~10 minutes hands-on prep), spatial transcriptomics early access with planned launch later in 2026, 18‑month NovaSeq X roadmap (14B and 35B flow cells, staggered runs, Q70 improvements), and BioInsight/billion cell atlas program.
Improving Long-Range Trajectory
Management reiterated pathway to high single-digit revenue growth, continued margin expansion (~350 bps implied by end of 2026 ex-acquisitions) and double-digit to teens EPS growth toward 2027 targets, reflecting confidence after Q1 outperformance.