Record Annual Revenue and Improved Profitability
Full year 2025 net product sales of $154.9 million and adjusted EBITDA of $14.7 million (more than doubling prior year performance), beating prior guidance of $9M–$13M. Gross margin approximately 73%, reflecting improved cost discipline and favorable product mix.
Acute Care Quarter Acceleration
Acute Care net sales of $16.3 million in Q4 2025, up ~33% quarter-over-quarter from $12.3 million (Q3). The Acute Care franchise increased more than 57% year-over-year in the quarter, signaling clear momentum heading into 2026.
ZYNRELEF Strong Growth and Reimbursement Progress
ZYNRELEF Q4 net sales of $12.5 million (up from $9.3 million in Q3) and 48% year-over-year revenue growth in the quarter. Reimbursement clarity improved with permanent J-code (J0668) and workflow simplifications (VAN rollout); prefilled syringe (PFS) program progressing with potential approval targeted mid- to late-2027.
APONVIE Rapid Adoption and Guideline Inclusion
APONVIE Q4 net sales $3.8 million, up 97% year-over-year; demand units grew ~101% YoY. Included in the Fifth Consensus Guidelines for PONV and granted a permanent product-specific J-code (J8502). Dedicated hospital-focused sales team (IBM group) launched to accelerate hospital adoption.
Successful Financing and Strong Balance Sheet
Completed a financing in 2025 that eliminated a capital-structure overhang, providing financial flexibility to increase targeted commercial investments and execute growth initiatives.
Concrete 2026 Guidance with Continued Profitability Target
Management provided 2026 guidance of $173M–$183M in net product sales and adjusted EBITDA of $10M–$20M, and reiterated an expectation to remain EBITDA positive while making targeted commercial investments to accelerate growth.
Operational Initiatives Driving Commercial Execution
Implemented CrossLink IGNITE incentive program (expanded into 2026), completed VAN rollout to reduce administration friction, and leveraged permanent coding and guideline inclusion to reduce hospital adoption barriers — all cited as drivers of improved distributor/hospital execution.