RYTELO U.S. Commercial Launch
RYTELO was recently approved as a first-in-class novel telomerase inhibitor for lower risk MDS with a significant market opportunity. Despite initial sales not meeting expectations, strategic investments and adjustments are being made to enhance its commercial success.
Increased Commercial Investments
The company is investing additional resources to increase brand awareness among U.S. hematologists. This includes expanding the sales team by more than 20% and implementing new roles to drive product uptake.
Encouraging Performance Indicators
Approximately 900 sites of care have utilized RYTELO, with about 300 new sites since the end of Q4. Demand grew approximately 10% in the recent four-week period, indicating the highest growth since October 2024.
Phase III Pivotal Trial in Myelofibrosis
The IMPACT MS Phase III trial in relapsed refractory myelofibrosis is designed to double RYTELO's commercial potential. Currently, about 85% enrolled, with interim analysis expected in the second half of 2026.
Strong Financial Position
Geron remains in a strong financial position with $457.5 million in cash and equivalents. They have access to additional funding under their debt agreement with Pharmacon if needed.