Clinical Timeline RiskExtended timelines for large late-stage trials and staggered oral and injectable programs prolong the wait for definitive efficacy and regulatory decisions, delaying commercialization clarity.
Financial And Competitive PressureRising research and development spending, recent financial misses, and ongoing manufacturing and competitive challenges increase the likelihood of future funding needs and potential shareholder dilution.
Maintenance Efficacy RiskMeaningful weight regain or high discontinuation rates in the maintenance study would weaken confidence in long-term effectiveness and could materially harm investor sentiment.