Revenue Growth and 2026 Guidance
Full-year 2025 revenue was $761 million, up from $675 million in 2024 (≈+12.8%). Company provided 2026 revenue guidance of $900 million to $1 billion.
Strong Cash Position and Capital Actions
Cash and investments at December 31, 2025 were $532 million; 2025 included $245 million of share repurchases under the repurchase program.
Commercial Demand Expansion for Cushing's Products
Record number of new prescriptions in 2025: new prescriptions increased 61% year-over-year; tablets delivered increased 37% year-over-year despite capacity constraints, and monthly new patient starts improving after pharmacy transition.
CATALYST Trial — Diabetes Population Findings
Prevalence phase screened 1,000 uncontrolled diabetes patients and found 24% had hypercortisolism; treatment phase (n=136) showed Korlym reduced mean HbA1c by 1.47% vs 0.17% for placebo (absolute delta ≈1.30%), plus large decreases in weight and waist circumference.
ROSELLA Phase III — Positive Oncology Outcomes
In platinum-resistant ovarian cancer, relacorilant plus nab‑paclitaxel reduced risk of death by 35% (HR 0.65, p=0.0004), with median overall survival extended by 4.1 months and up to 8 months longer at the 75th percentile; met both dual primary endpoints and full data to be presented at SGO.
DAZALS (ALS) Phase II — Large Mortality Signal
In DAZALS, patients receiving 300 mg dazucorilant for 1 year showed an 84% reduction in risk of death vs placebo (p=0.0009); company initiating dose-titration work to address tolerability and plans pivotal trial later this year.
Ongoing Pipeline Momentum and Upcoming Readouts
MONARCH Phase IIb (MASH) fully enrolled (175 patients) with results expected by year-end; MOMENTUM results (resistant hypertension prevalence/treatment) to be announced next month; multiple oncology and combination studies ongoing with anticipated data through 2027.
Resolved Pharmacy Capacity Transition
Completed transition to new specialty pharmacy (Curant) with final patient files received; company reports improving fulfillment metrics, on track for a monthly record for new patient starts and greater capacity/scalability going forward.