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VRTX Stock 12 Month Forecast
Average Price Target
$548.63
▲(17.98% Upside)
Based on 24 Wall Street analysts offering 12 month price targets for Vertex Pharmaceuticals in the last 3 months. The average price target is $548.63 with a high forecast of $625.00 and a low forecast of $466.00. The average price target represents a 17.98% change from the last price of $465.02.
Valuation and Risks. We are raising our PT to $518 from $478 as the JOURNAVX launch reaches a critical tipping point, validated by Q4 prescription volume matching the prior three quarters combined and the strategic 1Q26 unlock of all three national PBMs covering >200M lives. Our increased penetration assumptions are underpinned by robust KOL enthusiasm for suzetrigine’s 76–90% opioid-free success rates in real-world procedures, providing high visibility into management's guidance to triple annual scripts as they double the field force to 300 representatives.
We continue to believe Alyftrek and follow-on CFTR correctors will maintain Vertex’s leadership position in CF ahead of competitor clinical data this year. Beyond CF, we view both Journavx and Casgevy as at relative inflection points as Journavx weans off its patient support program to enable more favorable gross-to-net pricing and Casgevy revenues remain volatile amid new patient uptake dynamics. Together these products are guided to do at least $500 million in revenue in 2026 (more than 185% year-over-year growth).
Analysts Have Conflicting Sentiments on These Healthcare Companies: Align Tech (NASDAQ: ALGN), Vertex Pharmaceuticals (NASDAQ: VRTX) and Pfizer (NYSE: PFE)
Valuation and Risks. We are raising our PT to $518 from $478 as the JOURNAVX launch reaches a critical tipping point, validated by Q4 prescription volume matching the prior three quarters combined and the strategic 1Q26 unlock of all three national PBMs covering >200M lives. Our increased penetration assumptions are underpinned by robust KOL enthusiasm for suzetrigine’s 76–90% opioid-free success rates in real-world procedures, providing high visibility into management's guidance to triple annual scripts as they double the field force to 300 representatives.
We continue to believe Alyftrek and follow-on CFTR correctors will maintain Vertex’s leadership position in CF ahead of competitor clinical data this year. Beyond CF, we view both Journavx and Casgevy as at relative inflection points as Journavx weans off its patient support program to enable more favorable gross-to-net pricing and Casgevy revenues remain volatile amid new patient uptake dynamics. Together these products are guided to do at least $500 million in revenue in 2026 (more than 185% year-over-year growth).
Analysts Have Conflicting Sentiments on These Healthcare Companies: Align Tech (NASDAQ: ALGN), Vertex Pharmaceuticals (NASDAQ: VRTX) and Pfizer (NYSE: PFE)
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VRTX Analyst Recommendation Trends
Rating
Oct 25
Nov 25
Dec 25
Jan 26
Feb 26
Strong Buy
2
0
0
0
0
Buy
35
37
41
47
46
Hold
17
17
15
13
4
Sell
0
0
0
0
0
Strong Sell
0
0
0
0
0
total
54
54
56
60
50
In the current month, VRTX has received 46Buy Ratings, 4Hold Ratings, and 0Sell Ratings. VRTX average Analyst price target in the past 3 months is 548.63.
Each month's total comprises the sum of three months' worth of ratings.
VRTX Financial Forecast
VRTX Earnings Forecast
Next quarter’s earnings estimate for VRTX is $4.42 with a range of $3.67 to $4.91. The previous quarter’s EPS was $5.03. VRTX beat its EPS estimate ― of the time in the past 12 months, while its overall industry beat the EPS estimate 57.43% of the time in the same period. In the last calendar year VRTX has Performed in-line its overall industry.
Next quarter’s earnings estimate for VRTX is $4.42 with a range of $3.67 to $4.91. The previous quarter’s EPS was $5.03. VRTX beat its EPS estimate ― of the time in the past 12 months, while its overall industry beat the EPS estimate 57.43% of the time in the same period. In the last calendar year VRTX has Performed in-line its overall industry.
VRTX Sales Forecast
Next quarter’s sales forecast for VRTX is $3.07B with a range of $2.91B to $3.23B. The previous quarter’s sales results were $3.23B. VRTX beat its sales estimates ― of the time in past 12 months, while its overall industry beat sales estimates 49.17% of the time in the same period. In the last calendar year VRTX has Performed in-line its overall industry.
Next quarter’s sales forecast for VRTX is $3.07B with a range of $2.91B to $3.23B. The previous quarter’s sales results were $3.23B. VRTX beat its sales estimates ― of the time in past 12 months, while its overall industry beat sales estimates 49.17% of the time in the same period. In the last calendar year VRTX has Performed in-line its overall industry.
VRTX Stock Forecast FAQ
What is VRTX’s average 12-month price target, according to analysts?
Based on analyst ratings, Vertex Pharmaceuticals’s 12-month average price target is 548.63.
What is VRTX’s upside potential, based on the analysts’ average price target?
Vertex Pharmaceuticals has 17.98% upside potential, based on the analysts’ average price target.
Can I see which stocks the top-ranking analysts are rating?
Yes, go to the Analysts’ Top Stocks tool to see stocks with a Strong Buy or Strong Sell analyst rating consensus, according to the top performers.
How can I follow the stock ratings of top Wall Street analysts?
Head over to our Expert Center to see a list of the top 100 Wall Street analysts and follow the analysts of your choice. Visit their profiles for more details about their stock ratings and see how they perform on a stock-by-stock basis.
Is VRTX a Buy, Sell or Hold?
Vertex Pharmaceuticals has a consensus rating of Strong Buy which is based on 21 buy ratings, 3 hold ratings and 0 sell ratings.
What is Vertex Pharmaceuticals’s price target?
The average price target for Vertex Pharmaceuticals is 548.63. This is based on 24 Wall Streets Analysts 12-month price targets, issued in the past 3 months. The highest analyst price target is $625.00 ,the lowest forecast is $466.00. The average price target represents 17.98% Increase from the current price of $465.02.
What do analysts say about Vertex Pharmaceuticals?
Vertex Pharmaceuticals’s analyst rating consensus is a Strong Buy. This is based on the ratings of 24 Wall Streets Analysts.
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