Class Immunogenicity ConcernsMarked immunogenicity observed with a comparator therapy, where a substantial share of patients developed anti‑drug antibodies with some neutralizing activity, raises concerns about class safety, potential efficacy impacts, and adoption hurdles.
Financing RiskHigh cash burn and a limited cash runway create funding risk and increase dependence on capital markets to support late‑stage development and commercial preparation.
Market Sentiment / Short InterestElevated short interest representing a significant portion of the float signals investor skepticism that could translate into downside pressure or heightened stock volatility.