Competitive LandscapeCompetitor KALV’s Ekterly has a head start as the only approved oral option for acute hereditary angioedema, which could limit the market opportunity for PHVS's drug.
Market ChallengesEntering a crowded market and off-label usage of approved players is common for the rarer subtypes, indicating the need for a strong commercial plan.
Prophylactic Market CompetitionOral competitor BCRX’s Orladeyo, approved in 2020, has a significant head start in the prophylactic market, which could limit PHVS's usage to treatment failures.